“…Finite element (FE) models of femurs based on quantitative computed tomography (QCT) have been extensively used to estimate bone stiffness and strength ( Mann et al, 2008 ; Benca et al, 2017 ; Mosleh et al, 2020 ; Sullivan et al, 2020 ; Varga et al, 2020 ), which has been applied to predict fracture risk in bone diseases and metastases ( Arrington et al, 2006 ; Anez-Bustillos et al, 2014 ; Celik et al, 2019 ; Falcinelli et al, 2019 ; Nandi et al, 2022 ; Verbruggen and McNamara, 2023 ). Theories of bone adaptation that have been developed to predict changes in bone shape and density are based on strain ( Patel et al, 2014 ; Yang et al, 2014 ; Razi et al, 2015 ; Yang et al, 2017 ; Javaheri et al, 2020 ; Katz and Yosibash, 2020 ), stresses ( San Antonio et al, 2012 ; Celik et al, 2019 ; Falcinelli et al, 2019 ; Bruce Ralphin Rose, 2020 ), and strain energy density (SED) ( Cresswell et al, 2018 ; Lu et al, 2019 ).…”