Short sleep duration and physical and psychological health outcomes among adult survivors of childhood cancer

Lubas, Margaret M.; Mandrell, Belinda N.; Ness, Kirsten K.; Srivastava, Deo Kumar; Ehrhardt, Matthew J.; Wang, Zhaoming; Hudson, Melissa M.; Robison, Leslie L.; Krull, Kevin R.; Brinkman, Tara M.

doi:10.1002/pbc.28988

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…2,3 This substantial improvement in survival has resulted in a steadily growing population of childhood cancer survivors, who are, however, at increased risk of a wide range of somatic and psychiatric disorders, adverse mental late effects such as fatigue, neurocognitive sequelae (eg, impairments in memory), anxiety, depression, sleep disturbances and long-term socioeconomic consequences, such as lower educational attainment and unemployment. [4][5][6][7][8][9][10][11][12] These late effects may have a negative impact on the quality of life (QoL) of survivors. 13 For the sake of simplicity, the population of survivors who were diagnosed with cancer before the age of 21 will henceforth be referred to as childhood cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

“…As a result of more effective treatment, the 5‐year survival after childhood cancer has increased markedly over the past few decades and exceeds 80% in most European countries 2,3 . This substantial improvement in survival has resulted in a steadily growing population of childhood cancer survivors, who are, however, at increased risk of a wide range of somatic and psychiatric disorders, adverse mental late effects such as fatigue, neurocognitive sequelae (eg, impairments in memory), anxiety, depression, sleep disturbances and long‐term socioeconomic consequences, such as lower educational attainment and unemployment 4‐12 . These late effects may have a negative impact on the quality of life (QoL) of survivors 13 .…”

Section: Introductionmentioning

confidence: 99%

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Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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Advances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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“…Additionally, previous studies using both objective and self-reported methods did not show robust associations of SB with lower total body and lumbar spine aBMD z -score (12–14). Research in children and adolescents does not consistently show associations of sleep with aBMD parameters (15), but short sleep has been reported in almost half of 911 adult pediatric cancer survivors (16). The existing literature regarding the associations of physical activity, SB, and sleep with bone health in young pediatric cancer survivors is limited by important knowledge gaps including self-reported measures, small sample sizes, and methodological shortcomings.…”

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confidence: 99%

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

MARMOL-PEREZ,

MIGUELES,

UBAGO-GUISADO

et al. 2024

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose We aimed to examine the associations of 24-hour movement behaviors (moderate-to-vigorous physical activity [MVPA], light physical activity [LPA], sedentary behavior [SB] and sleep) with age-, sex- and race-specific areal bone mineral density (aBMD) Z-score parameters at clinical sites in young pediatric cancer survivors. Methods This cross-sectional multicenter study was carried out within the iBoneFIT framework in which 116 young pediatric cancer survivors (12.1 ± 3.3 years old; 42% female) were recruited. We obtained anthropometric and body composition data (i.e., body mass, stature, body mass index and region-specific lean mass), time spent in movement behaviors over at least seven consecutive 24-hour periods (wGT3x-BT accelerometer, ActiGraph) and aBMD Z-score parameters (age-, sex- and race-specific total at the body, total hip, femoral neck and lumbar spine). Survivors were classified according to somatic maturity (pre or peri/post-pubertal depending on the estimated years from peak height velocity). The adjusted models’ coefficients were used to predict the effect of reallocating time proportionally across behaviors on the outcomes. Results In pre-pubertal young pediatric cancer survivors, reallocating time to MVPA from LPA, SB and sleep was significantly associated with higher aBMD at total body (B = 1.765, P = .005), total hip (B = 1.709, P = .003) and lumbar spine (B = 2.093, P = .001). In peri/post-pubertal survivors, reallocating time to LPA from MVPA, SB and sleep was significantly associated with higher aBMD at all sites (B = 2.090 to 2.609, P = .003 to .038). Reallocating time to SB from MVPA or LPA was significantly associated with lower aBMD at most sites in pre-pubertal and peri/post-pubertal survivors, respectively. Finally, reallocating time to sleep from MVPA, LPA and SB was significantly associated with lower aBMD at total body (B = -2.572, P = .036) and total hip (B = -3.371, P = .015). Conclusions These findings suggest that every move counts and underline the benefits of increasing MVPA or LPA, when low MVPA levels are present, for bone regeneration following pediatric cancer treatment completion.

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Sleep interventions in pediatric oncology: A systematic review of the evidence

Daniel,

Catarozoli,

Crabtree

et al. 2024

Pediatric Blood & Cancer

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Sleep concerns are common during pediatric cancer treatment and can last into survivorship. The current systematic review sought to identify intervention studies that addressed sleep as a primary or secondary outcome during pediatric cancer treatment up to 5 years after completing treatment. Quality assessment was rated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. The review identified 16 studies with a total of 943 participants that tested a wide range of interventions including psycho‐educational, stress management techniques, medications, and physical activity. Most studies included tested interventions in small samples. None of the included studies had a high risk of bias for all domains, but all included studies had a high risk of bias for at least two risk domains. Several feasible pilot studies were identified that warrant further research to test efficacy. Implications for future research and clinical practice to manage sleep concerns are discussed.

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Short sleep duration and physical and psychological health outcomes among adult survivors of childhood cancer

Cited by 7 publications

References 48 publications

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

Sleep interventions in pediatric oncology: A systematic review of the evidence

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