Short sleep duration increases salivary IL-6 production

Reinhardt, Érica Lui; Fernandes, Pedro Augusto Carlos Magno; Markus, Regina Pekelmann; Fischer, Frida Marina

doi:10.3109/07420528.2016.1167710

Cited by 23 publications

(24 citation statements)

References 10 publications

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“… 32 , 33 As cytokines may modulate the sleep-wake cycle, sleep disturbances may upregulate proinflammatory cytokines, such as tumour necrosis factor-α, interleukin-1 and interleukin-6, which can have a profound impact on FD symptoms. 34 – 36 …”

Section: Discussionmentioning

confidence: 99%

Correlation between sleep impairment and functional dyspepsia

Huang

Shen

et al. 2020

J Int Med Res

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Objective Sleeping habits may greatly impact the prevalence of functional dyspepsia (FD). This study examined relationships between aspects of sleep impairment and FD. Methods This prospective study included university student volunteers. Following enrolment, FD was diagnosed based on the Rome IV criteria, dividing participants into an FD group or controls. The FD group was further subdivided into long-term (disease course >6 months) and short-term (disease course 3–6 months) FD groups. Participants completed the Pittsburgh Sleep Quality Index (PSQI), the Rome IV Diagnostic Questionnaire for Gastrointestinal Disorders in Adults, and a visual analogue scale (VAS). Results Out of 418 participants in total, sleep quality, latency, and duration, habitual sleep efficiency, sleep disturbances, sleep medication use, daytime dysfunction, and PSQI scores were higher in the FD groups versus controls. Components of PSQI scores emerged as risk factors, and were higher in the long-term versus short-term dyspepsia group. Moreover, these components were positively correlated with frequency/severity of postprandial distress syndrome and early satiation. Total PSQI scores were positively correlated with VAS scores. Conclusion Several PSQI components are associated with FD occurrence, symptom frequency, and symptom severity.

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Section: Discussionmentioning

confidence: 99%

Correlation between sleep impairment and functional dyspepsia

Huang

Shen

et al. 2020

J Int Med Res

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“…IL-6 was measured in 9 of the 13 articles analyzed [41,43,[45][46][47][48][49][50]52]. According to the study published by Li Zhang et al [49] on nurses who did shift work, IL-6 levels were correlated with the ISI (Insomnia Severity Index).…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

“…In the study by El-Sheikh et al [46], sleep-disordered breathing in children was directly associated with higher levels of salivary IL-6. Reinhardt et al [52] evaluated sleep quality by means of actigraphy measurements performed in healthy male workers of a welding company who worked morning shifts from 7 a.m. to 5 p.m. Workers with a shorter duration of sleep (< 6h) had higher levels of salivary IL-6 at bedtime and at 2 p.m. than workers with a longer duration of sleep (≥ 6h).…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

et al. 2021

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Poor sleep quality and sleep disorders are the most common problems in people, affecting health-related quality of life. Various studies show an association between sleep disorders and altered levels of stress hormones and inflammatory cytokines measured in saliva. The main objective of this article is to provide an analysis of the current evidence related to changes in inflammatory markers in the saliva and their associations with sleep quality measurement (both objective and subjective methods) in healthy subjects and in sleep-related disorders. To that end, a scoping review was carried out, following the PRISMA criteria in the bibliographic search in several databases: PubMed, EBSCO, and SCOPUS. Eleven of the articles are from the adult population and two from the child-youth population. They mainly measure the relationship between sleep and interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFα) alpha, as well as other inflammatory markers such as myeloperoxidase (MPO) and prostaglandin-endoperoxide synthase 2. An analysis shows the relationship between these salivary biomarkers and sleep quality, especially in the case of IL-6 in both healthy subjects and several pathologies associated with sleep-disorders. The results for TNFα and IL-1β measurements are still inconclusive and the difference with IL-6 was assessed. Two studies reported interventions that result in sleep improvement and are accompanied by the normalization of inflammatory changes detected in the saliva. As it is an easy-to-apply and non-invasive method, the measurement of salivary cytokines can be very useful in chronobiology studies. Further studies are required to determine the sensitivity of salivary inflammatory markers in monitoring biological rhythms and acting as biomarkers in the detection of sleep disorders and sleep interventions.

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“…In a study by Reinhardt et al (2016), the inflammatory marker interleukin-6 (IL-6) was assessed from saliva in permanent morning shift workers. The workers were stratified, on the basis of actigraphically assessed sleep duration, as workers with longer sleep duration (6 subjects) and shorter sleep duration (15 subjects).…”

Section: Working Time and Healthmentioning

confidence: 99%