Short Sleep Duration is Associated with Prolonged Virus Shedding in SARS-CoV-2 Omicron-Infected Patients

Zhou, Li; Liu, Zhuo Ran; Wang, Lele; Li, Shi Qi; Lu, Fang; Zhang, Liu; Li, Qing Yun

doi:10.2147/nss.s411677

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Chronic sleep loss and disturbed sleep promote not only a proinflammatory state, but also affect the number and function of immune regulating cells 32 , 33 and prolong shedding of SARS-CoV-2 after infection. 34 Both factors may promote viral persistence in tissues which is hypothesized as a mechanism resulting in PASC. 31 …”

Section: Discussionmentioning

confidence: 99%

Sleep and long COVID: Preexisting sleep issues and the risk of PASC in a large general population using 3 different model definitions

Quan,

Weaver,

Czeisler

et al. 2024

Preprint

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Study ObjectivesInsomnia, poor sleep quality and extremes of sleep duration are associated with COVID-19 infection. This study assessed whether these factors are related to Post-Acute Sequelae of SARS-CoV-2 infection (PASC).MethodsCross-sectional survey of a general population of 24,803 U.S. adults to determine the association of insomnia, poor sleep quality and sleep duration with PASC.ResultsPrevalence rates of PASC among previously COVID-19 infected participants for three definitions of PASC were COPE (21.9%), NICE (38.9%) and RECOVER PASC Score (15.3%). PASC was associated with insomnia in all 3 models in fully adjusted models with adjusted odds ratios (aORs) and 95% confidence intervals (CI) ranging from 1.30 (95% CI: 1.11-1.52, p≤0.05, PASC Score) to 1.52 (95% CI: 1.34-1.71, p≤0.001, (NICE). Poor sleep quality was related to PASC in all models with aORs ranging from 1.77 (95% CI: 1.60-1.97, p≤0.001, NICE) to 2.00 (95% CI: 1.77-2.26, p≤0.001, COPE). Sleep <6 hours was associated with PASC with aORs between 1.59 (95% CI: 1.40-1.80, p≤0.001, PASC Score) to 1.70 (95% CI: 1.53-1.89, p≤0.001, COPE). Sleep>9 hours was not associated with PASC in any model. Although vaccination with COVID-19 booster decreased the likelihood of developing PASC, it did not attenuate associations between insomnia, poor sleep quality and short sleep duration with PASC in any of the models.ConclusionsInsomnia, poor sleep quality and short sleep duration are potential risk factors for PASC. Interventions to improve sleep may decrease the development of PASC.Brief SummaryCurrent Knowledge/Study RationaleInsomnia, poor sleep quality, and extremes of sleep duration have been associated with a higher likelihood of COVID-19 infection. However, evidence implicating an association with the development of Post-Acute Sequelae of SARS-CoV-2 infection (PASC) is scant.Study ImpactResults indicate that insomnia, poor sleep quality and sleep duration<6 hours are associated with an increase in the prevalence of PASC among persons who have previously had a COVID-19 infection. The findings provide support for employing interventions to improve sleep as a means to decrease the development of PASC.

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Section: Discussionmentioning

confidence: 99%

Sleep and long COVID: Preexisting sleep issues and the risk of PASC in a large general population using 3 different model definitions

Quan,

Weaver,

Czeisler

et al. 2024

Preprint

View full text Add to dashboard Cite

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Pre-existing sleep disturbances and risk of COVID-19: a meta-analysis

Zhou,

Li,

Zhang

et al. 2024

eClinicalMedicine

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Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals

Xue,

Merikanto,

Delale

et al. 2024

Int J Obes

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Background Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep’s critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential. Methods We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires. Results Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found. Conclusions Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.

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Short Sleep Duration is Associated with Prolonged Virus Shedding in SARS-CoV-2 Omicron-Infected Patients

Cited by 3 publications

References 49 publications

Sleep and long COVID: Preexisting sleep issues and the risk of PASC in a large general population using 3 different model definitions

Sleep and long COVID: Preexisting sleep issues and the risk of PASC in a large general population using 3 different model definitions

Pre-existing sleep disturbances and risk of COVID-19: a meta-analysis

Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals

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