Short Sleep Duration is Associated with Reduced Leptin Levels and Increased Adiposity: Results from the Québec Family Study

Chaput, Jean‐Philippe; Després, Jean‐Pierre; Bouchard, Claude; Tremblay, Angelo

doi:10.1038/oby.2007.512

Cited by 447 publications

(350 citation statements)

References 27 publications

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“…The change in the ghrelin/leptin ratio between the two experimental conditions was significantly and positively correlated with changes in hunger ratings, suggesting that sleep restriction-induced alterations in these hormones may, in part, be driving observed increases in hunger ratings. These results are consistent with findings from two population-based studies that have also reported associations between short sleep duration, leptin, and ghrelin levels consistent with an up-regulation of appetite (71,72). Moreover, these associations were independent of BMI and other possible confounding factors.…”

Section: Methodology and Findings Of Previous Laboratory Studiessupporting

confidence: 82%

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Hanlon

Cauter

2011

Proc. Natl. Acad. Sci. U.S.A.

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Rates of obesity have been steadily increasing, along with disorders commonly associated with obesity, such as cardiovascular disease and type II diabetes. Simultaneously, average sleep times have progressively decreased. Recently, evidence from both laboratory and epidemiologic studies has suggested that insufficient sleep may stimulate overeating and thus play a role in the current epidemic of obesity and diabetes. In the human sleep laboratory it is now possible to carefully control sleep behavior and study the link between sleep duration and alterations in circulating hormones involved in feeding behavior, glucose metabolism, hunger, and appetite. This article focuses on the methodologies used in experimental protocols that have examined modifications produced by sleep restriction (or extension) compared with normal sleep. The findings provide evidence that sleep restriction does indeed impair glucose metabolism and alters the cross-talk between the periphery and the brain, favoring excessive food intake. A better understanding of the adverse effects of sleep restriction on the CNS control of hunger and appetite may have important implications for public health.

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Section: Methodology and Findings Of Previous Laboratory Studiessupporting

confidence: 82%

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Hanlon

Cauter

2011

Proc. Natl. Acad. Sci. U.S.A.

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“…Among obese women, the metabolically healthy reported 0.6 hours longer sleep duration than at risk obese. Although shorter sleep duration has often been associated with obesity in crosssectional and prospective studies, 33,34 this is the first report of an association with the at risk obesity phenotype. It is hypothesized that shorter sleep duration and obesity may be linked through neuroendocrine changes that influence appetite and favor a positive caloric balance, 34 or through behaviors often correlated with short sleep duration, such as television viewing time and consumption of high energy foods.…”

Section: Discussionmentioning

confidence: 98%

Diet Composition and Activity Level of at Risk and Metabolically Healthy Obese American Adults

Hankinson¹,

Daviglus²,

Horn³

et al. 2012

Obesity

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Obesity often clusters with other major cardiovascular disease risk factors, yet a subset of the obese appears to be protected from these risks. Two obesity phenotypes are described, 1) "metabolically healthy" obese, broadly defined as body mass index (BMI) ≥ 30 kg/m 2 and favorable levels of blood pressure, lipids, and glucose; and 2) "at risk" obese, BMI ≥ 30 with unfavorable levels of these risk factors. More than 30% of obese American adults are metabolically healthy. Diet and activity determinants of obesity phenotypes are unclear. We hypothesized that metabolically healthy obese have more favorable behavioral factors, including less adverse diet composition and higher activity levels than at risk obese in the multi-ethnic group of 775 obese American adults ages 40-59 years from the International Population Study on Macro/Micronutrients and Blood Pressure (INTERMAP) cohort. In gender stratified analyses, mean values for diet composition and activity behavior variables, adjusted for age, race, and education, were compared between metabolically healthy and at risk obese. Nearly 1 in 5 (149/775, or 19%) of obese American INTERMAP participants were classified as metabolically healthy obese. Diet composition and most activity behaviors were similar between obesity phenotypes, although metabolically healthy obese women reported higher sleep duration than at risk obese women. These results do not support hypotheses that diet composition and/or physical activity account for the absence of cardiometabolic abnormalities in metabolically healthy obese.

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“…Outra questão ainda sem conseso na literatura é a definição de privação de sono. As definições de duração de sono normal variam entre 6 a 9 horas por dia [35], porém distúrbios metabólicos e ganho de peso podem ser observados em indivíduos que dormem menos do que 6 horas por dia [42][43][44].…”

Section: Discussionunclassified

Associação entre privação do sono e obesidade em trabalhadores

Benvegnú¹,

Maffessoni²,

Fernandes³

et al. 2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACT Aims:To study the association between sleep deprivation and obesity among workers. Methods: We conducted a cross-sectional study of workers at a notebooks manufacturing in southern Brazil, which has three sectors of work (production line, back office and logistics), and the production sector works 24 hours a day. Demographic, socioeconomic, occupational and behavioral characteristics were obtained by a self-completion questionnaire, standardized and pre-tested. Weight and height measurements were self-reported and body mass index calculated. The cutoff point for obesity was ≥30 kg/m². Sleep duration was categorized into at least six hours a day and less than six hours a day (sleep deprivation). For bivariate analysis, chi-square test and test for linear trend were used. The crude and adjusted odds ratios were calculated using Poisson regression. Results:The final sample consisted of 193 workers, with a mean age of 34±11 years, 99 (51%) women. The prevalence of obesity was 27 (13.98%), and the prevalence of sleep deprivation was 40 (20.7%). Sleep deprivation has been associated with the production sector (p=0.011), the night shift (p<0.001) and physical inactivity (p=0.003). The presence of obesity was associated with sleep deprivation (p=0.006). After controlling for potential confounding factors, the likelihood of being obese was 2.37 (95% CI 1.08 to 5.21) times higher among workers in sleep deprivation. Conclusions:The results showed an association between sleep deprivation and obesity. In addition, sleep deprivation was associated with work on the night shift.

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Short Sleep Duration is Associated with Reduced Leptin Levels and Increased Adiposity: Results from the Québec Family Study

Cited by 447 publications

References 27 publications

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Diet Composition and Activity Level of at Risk and Metabolically Healthy Obese American Adults

Associação entre privação do sono e obesidade em trabalhadores

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