Short Sleep, Insomnia, and Cardiovascular Disease

Hsieh, Caleb; Martin, Jennifer L.

doi:10.1007/s40675-019-00157-8

Cited by 25 publications

(20 citation statements)

References 77 publications

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“… 40 Meanwhile, several sleep disorders characterized by short sleep duration might result in unbalancing of ANS activity. 41 Taken together, the abnormal HPA axis and imbalanced ANS may be the main connection link short sleep and other diseases including ED, and the signaling pathway between short sleep duration and ED is complicated and extensive.…”

Section: Sleepmentioning

confidence: 99%

Short Sleep Duration and Erectile Dysfunction: A Review of the Literature

Wang¹,

Xiong²,

Qin³

et al. 2022

NSS

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The meaning of sleep has puzzled people for millennia. In modern society, short sleep duration is becoming a global problem. It has been established that short sleep duration can increase the risk of several diseases, such as cardiovascular and metabolic diseases. Currently, a growing body of research has revealed a possible link between sleep disorders and erectile dysfunction (ED). However, the mechanisms linking short sleep duration and ED are largely unknown. Thus, we provide a review of clinical trials and animal studies. In this review, we propose putative pathways connecting short sleep duration and ED, including neuroendocrine pathways and molecular mechanisms, aiming to pave the way for future research. Meanwhile, the assessment and improvement of sleep quality should be recommended in the diagnosis and treatment of ED patients.

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Section: Sleepmentioning

confidence: 99%

Short Sleep Duration and Erectile Dysfunction: A Review of the Literature

Wang¹,

Xiong²,

Qin³

et al. 2022

NSS

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“…This has substantial public health implications. In recent years, sleep research has increasingly focused on the biological mechanisms underlying these associations between insomnia and somatic diseases, [8][9][10] with substantial attention on the effect of chronic sleep loss on inflammation.…”

Section: Introductionmentioning

confidence: 99%

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Xia¹,

Zhang²,

Niu³

et al. 2021

NSS

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Purpose To examine whether associations exist between chronic insomnia disorder (CID) and overlooked inflammatory factors (Serum amyloid protein A [SAA]), tumor necrosis factor [TNF]-α, granulocyte-macrophage colony-stimulating factor [GM-CSF], and regulated on activation and normal T cell expressed and presumably secreted [RANTES]). Patients and Methods A total of 65 CID patients and 39 sex- and age-matched good sleeper (GS) controls participated in this study. They completed a baseline survey to collect data on demographics, and were elevated sleep and mood by Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), 17-item Hamilton Depression Rating Scale (HAMD-17) and 14-item Hamilton Anxiety Rating Scale (HAMA-14), respectively. The blood samples were collected and tested the serum levels of SAA, TNF-α, GM-CSF and RANTES. Results The CID group had higher serum levels of SAA, TNF-α, and GM-CSF and a lower level of RANTES than the GS group. In the Spearman correlation analysis, SAA and GM-CSF positively correlated with the PSQI and AIS scores. After controlling for sex, HAMD-17 score, and HAMA-14 score, the partial correlation analysis showed that GM-CSF was positively correlated with PSQI score. Further stepwise linear regression analyses showed that GM-CSF was positively associated with the PSQI and AIS scores, while RANTES was negatively associated with them, and SAA was positively associated with just the AIS score. Conclusion The serum levels of inflammatory mediators (SAA, TNF-α, and GM-CSF) were significantly elevated and the level of RANTES was significantly decreased in CID patients and, to some extent, the changes are related to the severity of insomnia. These findings may help us to improve interventions to prevent the biological consequences of CID by inhibiting inflammation, thereby promoting health.

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“…PSG is needed for accurate sleep stage classification and was thus included in our home recording setup. As cardiovascular problems are often captured during night [38,39], we recorded the whole night ECG synchronizing it with PSG. The reproducibility of PSG and ECG was good; in only one patient the home ECG was missing.…”

Section: Discussionmentioning

confidence: 99%

Executability and repeatability of a study setup using wearable and computerized technology to examine a wide range of physiological and cognitive functions of a patient outside hospital

Müller

Rautalin

Arola

et al. 2023

Preprint

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Objectives: Reasons for daily problems of a patient are often unclear as they are not systematically monitored in daily life. To remedy this, we designed a study protocol combining outpatient laboratory and home measurements. Feasibility of the protocol was evaluated by examining its executability and repeatability. Participants: Sixteen patients undergoing neurosurgery for unruptured intracranial aneurysm (UIA), each acting as their own control. Study Protocol: Two laboratory examinations followed by home recordings at 2 weeks pre- and 4-6 weeks postoperatively. In between a sole home recording at 3 weeks and 3 months postoperatively. Subjective health and performance data were gathered via an internet portal. Methods: Laboratory Day included computer-based cognitive tests on attention, working memory and executive functions. Electroencephalography (EEG), electrocardiography (ECG) and electrodermal activity (EDA) were recorded during the tests. A saccade test with electro-oculography (EOG) and event-related potentials (ERP) to emotionally loaded sounds were also done. First three home recordings included tablet-based cognitive tests, sleep polysomnography (PSG), ECG, and actigraphy; the 4th only an actigraphy and sleep diary. Outcome measures: Executability and repeatability of the protocol: Number of patients completing the study, success rate of carrying it out as planned, obtained data and patient feedback. Results: In 13 (81%) patients all data from home recordings was obtained as planned. In 11 (68%) patients the whole protocol was carried out as planned and in 3 partly. The time schedules required adjusting. Patients reported no discomfort from using wearable devices. Patients considered answering the internet-based health questionnaires cumbersome: all data was obtained only in 30%. Conclusions: Mobile technologies are a tool kit from which to choose a clinically relevant combination to obtain objective data on physical, physiologic, and cognitive performance of a patient outside hospital.

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Short Sleep, Insomnia, and Cardiovascular Disease

Cited by 25 publications

References 77 publications

Short Sleep Duration and Erectile Dysfunction: A Review of the Literature

Short Sleep Duration and Erectile Dysfunction: A Review of the Literature

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Executability and repeatability of a study setup using wearable and computerized technology to examine a wide range of physiological and cognitive functions of a patient outside hospital

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