Short Stature in Children

Albalawi, Nouf; Alsabah, Badriah Abdulrahman; Alrefaei, Ahmed; Alatawi, Areej Mohammed; Albalawi, Maha Salem; Al-Enazi, Zainab Metaeb Mohammed Monaked; Albalawi, Mashael Zayed M; Alshehri, Ashwag Ahmed M; Alqarni, Wejdan Abdulrahman Ali

doi:10.12816/0043081

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…Hence, an evaluation of a child’s body height is important for preventing developmental abnormalities as short stature in an apparently healthy child may be indicative of an undiagnosed illness. Diagnosis of abnormal height may permit early identification of the cause, and therapies to normalize body height can be introduced at a later time 4 .…”

Section: Introductionmentioning

confidence: 99%

Growth disorders in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Perenc

Guzik

Drużbicki

2019

Sci Rep

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We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseases associated with neurodysfunction, we analyzed data collected during admission to the Neurological Rehabilitation Ward for Children and Adolescents. The study applied a retrospective analysis of data collected during hospitalization of 327 children and adolescents, aged 4–18 years, affected by congenital disorders of the nervous system and/or neurological syndromes associated with a minimum of one neurodysfunction. Two assessment systems were taken into account – one system traditionally applied, and another one in accordance with indications approved by the Food and Drug Administration, related to diagnosing short stature. The findings show more frequent co-occurrence of, as well as statistically significant correlations between, short stature in certain groups: operated myelomeningocele with hydrocephalus in the subgroup of neural tube defects (p = 0.029), tetraplegia in the subgroup of spastic cerebral palsy (p < 0.001), and hypothyroidism (p = 0.04) in the entire study group.

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Section: Introductionmentioning

confidence: 99%

Growth disorders in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Perenc

Guzik

Drużbicki

2019

Sci Rep

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“…Short stature has been described by paediatricians and endocrinologists as an indicator of health problems (Cohen 2008). Short stature, among other things, might be an indicator of some health conditions (such as Turner syndrome, Prader-Willi syndrome), or of malnutrition (Nouf Albalawi et al 2018). Some studies show that small height is associated with health problems later in life (albeit without a causal relationship), such as mortality (Engeland et al 2003), chronic disease (Perelman 2014), and greater risks for psychosis and suicide (Magnusson et al 2005).…”

Section: Current Bioethical Discussionmentioning

confidence: 99%

“…This is an approved indication worldwide (e.g. in the US, EU, Egypt, Gulf Cooperation Council countries, China; Grimberg et al 2016a, EMA 2012, Nouf Albalawi et al 2018, Al Herbish et al 2016, Xue 2016. Some athletes and bodybuilders use hGH illicitly to improve their performances, and some private clinics use it as an anti-ageing drug (Morrison 2008).…”

Section: Introductionmentioning

confidence: 99%

Critical paediatric bioethics and the treatment of short stature : an interdisciplinary study

Murano

2019

Linköping Studies in Arts and Sciences

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Linköping Studies in Arts and Sciences  No. 764 At the Faculty of Arts and Science at Linköping University, research and doctoral studies are carried out within broad problem areas. Research is organized in interdisciplinary research environments and doctoral studies mainly in graduate schools. Jointly, they publish the series Linköping Studies in Arts and Science. This thesis comes from the PHOENIX Erasmus Mundus Joint Doctoral Programme on Dynamics of Health and Welfare at the Department of Culture and Communication.

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“…Diagnosis of short stature can be accomplished in two concerted ways, physical examination and laboratory testing. Treatment for short stature mainly depends on the correct diagnosis and the causative agent (Albalawi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Association between lipid profile and other biochemical parameters with growth hormone in children and adolescents with short stature

Falih

Al-Fartusie

Tahir

2020

ijrps

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Short stature is a general term that usually accompanies a lack of growth hormone among people, and is more common among children. In this study, some kidney functions and lipid profile tests were evaluated in children and adolescents with short stature to find any relationship between the disturbance in these parameters and the etiology of short stature. A total of 60 short stature patients with a growth hormone deficiency, age range between 4-18 years, along with 60 age-matched healthy volunteers, were included in this study. Serum levels of GH, IGF-1, urea, and creatinine, as well as lipid profile, were determined, and then statistical analysis was performed on the collected data. The obtained results indicated a significant decrease in serum levels of GH and IGF-1 (p <0.01) in patients compared to control values. The results also indicated a substantial increase in serum levels of triglycerides and VLDL, mainly seen in children, and reported non-significant differences in HDL, LDL, and urea levels for GHD patients compared to control values. Additionally, the results showed a significant increase in the creatinine level of adolescent patients only. This study concluded that there is a clear relationship between disturbances in creatinine levels and the promotion of GHD in short stature patients. Current work has demonstrated that anomalies in the lipid profile, especially triglycerides and VLDL, are closely related to the causes of short stature. Finally, and most importantly, we can suggest that triglycerides and VLDL may help identify patients at an early age who are at risk of short stature, especially children.

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Short Stature in Children

Cited by 9 publications

References 22 publications

Growth disorders in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Growth disorders in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Critical paediatric bioethics and the treatment of short stature : an interdisciplinary study

Association between lipid profile and other biochemical parameters with growth hormone in children and adolescents with short stature

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