Short-term adaptation and incremental responses of single auditory-nerve fibers

Smith, Robert L.; Zwislocki, J. J.

doi:10.1007/bf00364166

Cited by 198 publications

(140 citation statements)

References 30 publications

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“…7 and 11). For example, consistent with Smith and Zwislocki (1975) and Zilany et al (2009), the simulations showed that firing to the signal increased roughly the same amount in the short and long-delay conditions. Figure 12B illustrates this finding, where the mean difference from Eq.…”

Section: Detectability Analysis For Simulations Without the Mocrsupporting

confidence: 86%

“…In addition to these properties, the power law model now accounts for properties of CFR adaptation that were not accounted for by previous versions of the model. Among these properties is the ability to predict a constant incremental response in the presence of adaptation (Smith and Zwislocki 1975). Furthermore, the power law model accounts for the recent observation that DR adaptation exists in AN responses from anesthetized cats (Zilany and Carney 2010).…”

Section: Methodsmentioning

confidence: 99%

“…This hypothesis is based on the prediction that a constant incremental response in the presence of adaptation should improve threshold by 3-5 dB (Smith and Zwislocki 1975). Furthermore, CFR adaptation has been hypothesized to account for the level dependence of overshoot based on differences in onset responses and thresholds of high and low spontaneous-rate (SR) fibers (McFadden and Champlin 1990).…”

Section: Introductionmentioning

confidence: 99%

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Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Jennings

Heinz

Strickland

2011

JARO

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Masked detection threshold for a short tone in noise improves as the tone's onset is delayed from the masker's onset. This improvement, known as "overshoot," is maximal at mid-masker levels and is reduced by temporary and permanent cochlear hearing loss. Computational modeling was used in the present study to evaluate proposed physiological mechanisms of overshoot, including classic firing rate adaptation and medial olivocochlear (MOC) feedback, for both normal hearing and cochlear hearing loss conditions. These theories were tested using an established model of the auditory periphery and signal detection theory techniques. The influence of several analysis variables on predicted tone-pip detection in broadband noise was evaluated, including: auditory nerve fiber spontaneousrate (SR) pooling, range of characteristic frequencies, number of synapses per characteristic frequency, analysis window duration, and detection rule. The results revealed that overshoot similar to perceptual data in terms of both magnitude and level dependence could be predicted when the effects of MOC efferent feedback were included in the auditory nerve model. Conversely, simulations without MOC feedback effects never produced overshoot despite the model's ability to account for classic firing rate adaptation and dynamic range adaptation in auditory nerve responses. Cochlear hearing loss was predicted to reduce the size of overshoot only for model versions that included the effects of MOC efferent feedback. These findings suggest that overshoot in normal and hearing-impaired listeners is mediated by some form of dynamic range adaptation other than what is observed in the auditory nerve of anesthetized animals. Mechanisms for this adaptation may occur at several levels along the auditory pathway. Among these mechanisms, the MOC reflex may play a leading role.

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Section: Detectability Analysis For Simulations Without the Mocrsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Jennings

Heinz

Strickland

2011

JARO

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“…The path with fast powerlaw dynamics contributes to the unsaturated onset response and to the "additivity" observed in AN rate responses to stimuli with amplitude increments. Several studies have confirmed that the process of short-term adaptation is additive in nature ͑Smith and Zwislocki, 1975;Smith, 1977;Abbas, 1979͒, meaning that the change in firing rate in response to an increment/decrement in stimulus level does not greatly depend on the time between the onset and the subsequent change in level. Smith et al ͑1985͒ showed that this property also holds if increment responses are analyzed with different window lengths that separate the portions of the response associated with rapid and short-term adaptation.…”

Section: Introductionmentioning

confidence: 93%

A phenomenological model of the synapse between the inner hair cell and auditory nerve: Long-term adaptation with power-law dynamics

Zilany

Bruce²,

Nelson³

et al. 2009

The Journal of the Acoustical Society of America

318

346

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There is growing evidence that the dynamics of biological systems that appear to be exponential over short time courses are in some cases better described over the long-term by power-law dynamics. A model of rate adaptation at the synapse between inner hair cells and auditory-nerve ͑AN͒ fibers that includes both exponential and power-law dynamics is presented here. Exponentially adapting components with rapid and short-term time constants, which are mainly responsible for shaping onset responses, are followed by two parallel paths with power-law adaptation that provide slowly and rapidly adapting responses. The slowly adapting power-law component significantly improves predictions of the recovery of the AN response after stimulus offset. The faster power-law adaptation is necessary to account for the "additivity" of rate in response to stimuli with amplitude increments. The proposed model is capable of accurately predicting several sets of AN data, including amplitude-modulation transfer functions, long-term adaptation, forward masking, and adaptation to increments and decrements in the amplitude of an ongoing stimulus.

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“…During simultaneous burst presentation, their combined input amplitude was doubled, but, because of the peripheral compression, the neural output was increased only by roughly a square root of 2. At short time intervals, a well known desensitization of single nerve fibers takes place, whose recovery can be grossly approximated by an exponential function with a time constant on the order of 2 ϭ 50 msec (26). The desensitization very likely decreased the response to the second burst.…”

Section: Summation Of Contralateral Muscle Responsesmentioning

confidence: 99%

Auditory system: Peripheral nonlinearity and central additivity, as revealed in the human stapedius-muscle reflex

Zwislocki¹

2002

Proc. Natl. Acad. Sci. U.S.A.

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3-kHz, 20-msec tone bursts were determined indirectly by measuring the associated acoustic-impedance changes at the tympanic membrane with an acoustic bridge. The measurement was possible because the bridge practically eliminates the effect of the ear-canal air volume interposed between the tympanic membrane and the tip of the measuring tube. By using burst pairs, temporal additivity of the muscle responses was demonstrated both when the stimulus bursts were presented contralaterally to the measured impedance changes and when the first burst was presented ipsilaterally. The summation time constant was on the order of 200 msec, much longer than the twitch time constant of the muscle fibers. Therefore, the summation had to take place in a nucleus preceding the stapedius muscle. The magnitude of the muscle response obeyed a compressive function paralleling the loudness function up to sound pressure levels of at least 120 dB.contralateral contraction

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Short-term adaptation and incremental responses of single auditory-nerve fibers

Cited by 198 publications

References 30 publications

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

Evaluating Adaptation and Olivocochlear Efferent Feedback as Potential Explanations of Psychophysical Overshoot

A phenomenological model of the synapse between the inner hair cell and auditory nerve: Long-term adaptation with power-law dynamics

Auditory system: Peripheral nonlinearity and central additivity, as revealed in the human stapedius-muscle reflex

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