2022
DOI: 10.1111/ijd.16303
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Short‐term administration of Polypodium leucotomos extract does not inhibit CYP3A4‐mediated metabolism of midazolam in healthy subjects: an open‐label, two‐period, fixed‐sequence study

Abstract: The extract of Polypodium leucotomos is used as a dietary supplement for its ultraviolet radiation-protective properties. Polypodium leucotomos extract reportedly inhibits CYP3A, which is important for drug metabolism in vitro in human microsomes and in vivo in rats.In this study, we explored the inhibitory effect of the P. leucotomos extract on CYP3A4mediated midazolam metabolism in humans. This open-label, two-period, fixed-sequence study was performed on six healthy, Japanese, male volunteers. During period… Show more

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