Short-Term Administration of Rifampin in the Prevention or Eradication of Infection Due to Foreign Bodies

Antimicrobial Treatment of Orthopedic Implant-related Infections with Rifampin Combinations

“…Failure of therapy was observed for two patients who had delayed infection and for whom antimicrobial treatment was considered inappropriate. The excellent success rate in our study (82%) confirms data from in vitro and animal experiments [3,4,7,8]. A recent study showed that a cure rate of 90% can be achieved with combination therapy with ofloxacin and rifampin [9].…”

“…New antimicrobial regimens may cure infections that were previously considered as necessitating removal of the device [2]. We previously observed in an animal model that even short-term treatment with rifampin can sterilize implant-related infections due to Staphylococcus epidermidis and Staphylococcus aureus [3][4][5]. The present trial was designed as a pilot study for evaluating whether a rifampin-containing regimen could cure ODRIs rather than only suppress the clinical symptoms.…”

Penetration of rifampicin into the brain tissue and cerebral extracellular space of rats

“…Rifampicin concentrations were measured by agar diffusion bioassay, using Sarcina lutea as the indicator strain (Tshefu, Zimmerli & Waldvogel, 1983). Standard solutions were prepared from the commercially available iv preparation of rifampicin by diluting stock solutions with pooled serum, resulting in a final serum concentration of 50%.…”

Single-Dose Rifampin Prophylaxis for Experimental Endocarditis Induced by High Bacterial Inocula of Viridans Streptococci

“…In the present experiments, single-dose rifampin provided serum levels above the MIC for both S. intermedius and S. sanguis for at least 12 hr. Moreover, it is likely that rifampin provided growth inhibition for a longer duration than the mere period of circulating rifampin levels: Bacterial numbers in vegetations from prophylaxis failures seven days after administration of rifampin were significantly lower than in controls, a result suggesting a prolonged in vivo suppression of bacterial growth, A similar phenomenon has been observed after amoxicillin prophylaxis of streptococcus endocarditis [3] and after rifampin prophylaxis of a foreign-body infection due to Staphylococcus aureus [20]. Moreover, a prolonged in vitro postantibiotic effect has been demonstrated for rifampin-exposed S. aureus [21].…”