Short-term aerobic training does not improve memory functioning in relapsing remitting multiple sclerosis – a randomized controlled trial

Abstract

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in MS. Objective and methods This randomized controlled trial aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting MS. The primary outcome was verbal memory (Verbal learning and memory test, VLMT). Patients were randomized to an intervention group (IG) program or a waitlist control group (CG). Patients in the IG exercised according to an individually tailored training schedule (with 2-3 sessions per week for 12 weeks). The primary analysis was carried out using the intention-to-treat (ITT) sample with ANCOVA adjusting for baseline scores. Results 77 RRMS patients were screened and 68 participants randomized (CG n=34; IG n=34). The sample comprised 68% females, had a mean age of 39 years, a mean disease duration of 6.3 years, and a mean EDSS of 1.8. No significant effects were detected in the ITT analysis for the primary endpoint VLMT or any other cognitive measures. Moreover, no significant treatment effects were observed for quality of life, fatigue, or depressive symptoms. Conclusion This study failed to demonstrate beneficial effects of aerobic exercise on cognition in RRMS. The trial was prospectively registered at clinicaltrials.gov (NCT02005237).

Arm Ergometry to Improve Mobility in Progressive Multiple Sclerosis (AMBOS)—Results of a Pilot Randomized Controlled Trial

“…Based on an earlier trial (10), we conducted a pilot study for arm ergometry in pwMS. In contrast to previous center-based interventions (10,32), AMBOS aimed to establish a high-frequency home-based training. This study showed that a high frequency at home training is feasible for 3 months with a substantial number of 67 sessions.…”

“…Spiroergometry results at baseline provided the anchor for the individualized training schedule. Specifically, the aerobic threshold as described earlier was determined (32). To validate the resulting training parameters, participants performed a briefing and familiarization session on the training tool Motomed (Reck, Betzenweiler, Germany) a few days later (see Figure 2).…”