Short-term air pollution exposure is a risk factor for acute coronary syndromes in an urban area with low annual pollution rates: Results from a retrospective observational study (2011–2015)

Gestro, Massimo; Condemi, Vincenzo; Bardi, Luisella; Tomaino, Laura; Roveda, Eliana; Bruschetta, Antongiulio; Solimene, Umberto; Esposito, Fabio

doi:10.1016/j.acvd.2020.03.013

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…Liu et al, presented an association between a 10 μg/m 3 increase in air pollutants (PM 2.5 , PM 10 , NO 2 ) and myocardial infarction (MI) mortality on LAG 0 and LAG 1 in the overall population, which comes in line with our results [ 25 ]. Additionally, a study conducted in the region with relatively low levels of air pollutants by Gestro et al, showed that exposure to PM 2.5 was a risk factor for ACS incidence, particularly in elderly people [ 26 ]. Short-term exposure to all three analyzed air pollutants was related to greater incidence and mortality due to STEMI in Barcelona, Spain [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)

Święczkowski

Dobrzycki

Kuźma

2023

IJERPH

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Polish smog is a specific type of air pollution present in Eastern Poland, which may cause particularly adverse cardiovascular effects. It is characterized primarily by high concentrations of particulate matter (PM) and different favorable conditions of formation. Our study aimed to assess whether PM and nitrogen dioxide (NO2) have a short-term impact on mortality due to acute coronary syndrome (ACS) and ischemic stroke (IS). The study covered the years 2016–2020, a total of 6 million person-years from five main cities in Eastern Poland. To evaluate the association between air pollution and cause-specific mortality, a case-crossover study design with conditional logistic regression was used at days with LAG from 0 to 2. We recorded 87,990 all-cause deaths, including 9688 and 3776 deaths due to ACS and IS, respectively. A 10 μg/m3 increase in air pollutants was associated with an increase in mortality due to ACS (PM2.5 OR = 1.029, 95%CI 1.011–1.047, p = 0.002; PM10 OR = 1.015, 95%CI 1–1.029, p = 0.049) on LAG 0. On LAG 1 we recorded an increase in both IS (PM2.5 OR = 1.03, 95%CI 1.001–1.058, p = 0.04) and ACS (PM2.5 OR = 1.028, 95%CI 1.01–1.047, p = 0.003; PM10 OR = 1.026, 95%CI 1.011–1.041, p = 0.001; NO2 OR = 1.036, 95%CI 1.003–1.07, p = 0.04). There was a strong association between air pollution and cause-specific mortality in women (ACS: PM2.5 OR = 1.032, 95%CI 1.006–1.058, p = 0.01; PM10 OR = 1.028, 95%CI 1.008–1.05, p = 0.01) and elderly (ACS: PM2.5 OR = 1.03, 95%CI 1.01–1.05, p = 0.003; PM10 OR = 1.027, 95% CI 1.011–1.043, p < 0.001 and IS: PM2.5 OR = 1.037, 95%CI 1.007–1.069, p = 0.01; PM10 OR = 1.025, 95%CI 1.001–1.05, p = 0.04). The negative influence of PMs was observed on mortality due to ACS and IS. NO2 was associated with only ACS-related mortality. The most vulnerable subgroups were women and the elderly.

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Section: Discussionmentioning

confidence: 99%

Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)

Święczkowski

Dobrzycki

Kuźma

2023

IJERPH

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“…Abbreviations: RR, relative risk; PM 2.5 , particulate matter with an aerodynamic diameter ≤ 2.5 μm; PM 10 , particulate matter with an aerodynamic diameter ≤ 10 μm; SO 2 , sulfur dioxide; NO 2 , nitrogen dioxide; CO, carbon monoxide; O 3 , ozone ◂ increased risk of respiratory disease to PM 10 (RR = 1.008 per 10 μg/m 3 , 95% CI 1.002-1.013) was observed in the elderly (Song et al 2021). An Italian research which investigated the association between short-term exposure to air pollutants and the acute coronary syndrome admissions in ED found that PM 2.5 exposure was a significant risk factor for those elderly patients (RR = 1.06, 95% CI 1.02-1.11) (Gestro et al 2020). PM 10 exposure also was identified as an increasing risk factor of acute gout flares, particularly in elderly (Ryu et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Air pollution and hospital admissions for critical illness in emergency department: a tertiary-center research in Changsha, China, 2016–2020

Lin

Long

et al. 2021

Environ Sci Pollut Res

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We aimed to comprehensively investigate the associations of air pollutants with hospital admissions for critical illness in ED. Patients with critical illness including level 1 and level 2 of the Emergency Severity Index admitted in ED of Changsha Central Hospital from January 2016 to December 2020 were enrolled. Meteorological and air pollutants data source were collected from the National Meteorological Science Data Center. A Poisson generalized linear regression combined with a polynomial distributed lag model (PDLM) was utilized to explore the effect of air pollution on hospital admissions for critical illness in ED. Benchmarks as references (25th) were conducted for comparisons with high levels of pollutant concentrations (75th). At first, lagged effects of all different air pollutants were analyzed. Then, based on the most significant factor, analyses in subgroups were performed by gender (male and female), age (< 45, 45-65, and > 65), disorders (cardiovascular, neurological, respiratory), and seasons (spring, summer, autumn, and winter). A total of 47,290 patients with critical illness admitted in ED were included. The effects of air pollutants (PM 2.5 , PM 10 , SO 2 , NO 2 , O 3 and CO) on critical illness ED visits were statistically significant. Strong collinearity between PM 2.5 and PM 10 (r = 0.862) was found. Both single-day lag and cumulative-day lag day models showed that PM 2.5 had the strongest effects (lag 0, RR = 1.025, 95% CI 1.008-1.043, and lag 0-14, RR = 1.067, 95% CI 1.017-1.120, respectively). In both PM 2.5 and PM 10 , the risks of critical illness in male, > 65 ages, respiratory diseases, and winter increased the most significant. Air pollutants, especially PM 2.5 and PM 10 exposure, could increase the risk of critical illness admission.

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“…Epidemiological studies have shown that exposure to PM 2.5 could increase the risk of cardiopulmonary diseases (Gestro et al, 2020; Newby et al, 2015). Mechanistically, inflammation response and oxidative stress are the very important mechanisms that linked with the adverse health effects on cardiopulmonary system of PM 2.5 exposure (Du, Xu, Chu, Guo, & Wang, 2016; Dutta et al, 2012; Pope III et al, 2016; Riva et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

Qiu

Chen²,

Wang

et al. 2020

Phytotherapy Research

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Exposure to PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 μm) has been associated with increased cardiopulmonary outcomes, mediated by a hypothesized biological mechanism of systemic inflammation and oxidation. This randomized, double‐blinded and placebo‐controlled trial among 120 healthy adults in Wuhan, China, was conducted to evaluate whether the supplementation of herbal product composed of Ginseng, Lilii Bulbus and Poria (GLP) which have been shown to have anti‐inflammatory and anti‐oxidant activity offers protective effects on PM2.5‐induced damage to cardiopulmonary health. Participants received four rounds of health examinations and two rounds of blood sample collection from November 2018 to January 2019. Compared to the placebo group, the GLP group showed significant increased antioxidant biomarkers such as superoxide dismutase (SOD) and paraoxonase1 (PON1). What is more, interleukin‐6 (IL‐6), an inflammatory biomarker, was significantly decreased in the GLP group. In addition, nitric oxide and club cell secretory protein (CC16) were increased but heart rate was decreased in the GLP group. As for pulmonary function indicators, significantly increased fractional exhaled nitric oxide (FeNO) was observed in the GLP group. Taken together, we concluded that GLP supplementation is associated with decreased inflammatory biomarker and increased antioxidant biomarkers suggesting cardiopulmonary benefits against PM2.5 exposure among young adults in China.

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Short-term air pollution exposure is a risk factor for acute coronary syndromes in an urban area with low annual pollution rates: Results from a retrospective observational study (2011–2015)

Cited by 10 publications

References 29 publications

Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)

Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)

Air pollution and hospital admissions for critical illness in emergency department: a tertiary-center research in Changsha, China, 2016–2020

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

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Short-term air pollution exposure is a risk factor for acute coronary syndromes in an urban area with low annual pollution rates: Results from a retrospective observational study (2011–2015)

Cited by 10 publications

References 29 publications

Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)

Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)

Air pollution and hospital admissions for critical illness in emergency department: a tertiary-center research in Changsha, China, 2016–2020

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM2.5 in air pollution‐induced cardiopulmonary damage among adults

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Product

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About

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults