SHORT-TERM ANAPHYLACTIC IgG ANTIBODIES IN HUMAN SERA

Parish, W. E.

doi:10.1016/s0140-6736(70)90170-4

Cited by 275 publications

(88 citation statements)

References 7 publications

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“…However, there have been reports that IgG fractions also have reaginic activity as shortterm sensitizing antibody to mast cells existing in lung and skin tissue (Parish, 1970). Our study revealed that several vaccinees possessed higher concentrations of IgG-specific antibodies to egg protein, OA and OM antigens.…”

Section: Discussionmentioning

confidence: 52%

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Yamane

Uemura

1988

Epidemiol. Infect.

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SUMMARYThe concentrations of serum IgE (PRIST) and IgE-and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16 % of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (Fl) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to F1 allergen rose significantly in a considerable number of the vaccinees. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

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Section: Discussionmentioning

confidence: 52%

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Yamane

Uemura

1988

Epidemiol. Infect.

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“…The total IgE levels in DR are normal, contrasting to the greatly increased levels seen in atopies [25]. Furthermore, experiments with the some what less sensitive PCA in monkeys, sensi tized with serum samples of 106 DR. con firm absence of skin-fixing, reaginic anti bodies with dextran reactivity, and of short term homocytotropic IgG antibodies [42]. Even the patient's serum with the highest level of DRA measured by RAST gave neg ative results upon transfer to monkey skin and challenge with dextran.…”

Section: Discussionmentioning

confidence: 88%

Dextran-induced Anaphylactoid Reactions in Man

Hedin¹,

Richter²,

Ring³

1976

Int Arch Allergy Immunol

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Dextran reactive antibodies (DRA) were studied in 123 patients having experienced dextran-induced anaphylactoid reactions (DIAR) during 1970–1975. No evidence for reaginic DRA was obtained by radioallergosorbent technique and passive cutaneous anaphylaxis in Cynomolgus monkeys; total IgE levels were within normal range. It is concluded that DIAR are not mediated by dextran-specific reagins. Further, no reaginic antibodies against potential contaminants from the dextran manufacturing process were demonstrable. In two population samples of normal human sera from Sweden and Germany hemagglutinating DRA (IgG, IgA, and IgM classes) were found in 63 and 74%, high titres (16–256) comprising 14 and 25%. In dextran reactors a direct positive correlation between titres of hemagglutinating DRA and increasing severity of DIAR was observed. The accumulation of high DRA titres in severe reactions may be taken as circumstantial evidence for the causal role of hemagglutinating DRA in these cases. However, if high titres of DRA alone were responsible for triggering DIAR, the expected frequency would be more than thousand times higher than the reported global incidence of DIAR. To explain this discrepancy, involvement of certain Ig classes or subgroups, possibly in combination with other predisposing factors is suggested. In mild reactions DRA appear to play a negligible role. Positive dextran wheal and flare reactions, often correlated with high titres of hemagglutinating DRA, were seen in 32% of dextran reactors, indicating that skin tests are of limited predictive value. No significant difference between sexes, age groups, or pre- and intraoperatively started dextran infusions was observed; association with certain diseases was not apparent.

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“…Afterwards, histamine-releasing IgG antibodies were also demonstrated in human serum and designated ‘short-term sensitizing’ because of shorter time of action compared to IgE [13]. Many authors hypothesized that they could provoke a number of allergic diseases in which specific IgE antibodies are not detected.…”

Section: Discussionmentioning

confidence: 99%

Food-Specific IgG4 Lack Diagnostic Value in Adult Patients with Chronic Urticaria and Other Suspected Allergy Skin Symptoms

Antico

Pagani

Vescovi

et al. 2010

Int Arch Allergy Immunol

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Background: Specific IgG4 dosing against food is proposed to the public by a lot of commercial laboratories as a reliable method to diagnose food intolerance. Actually, few data on IgG4 responses to foods in adults are available in the literature. In this study we evaluated the clinical utility of specific IgG4 dosing against food in adult patients with suspected food allergy/intolerance. Methods: A case series of 73 adult patients with suspected food allergy and clinical manifestations of chronic urticaria or other allergy-supposed skin symptoms were tested for specific IgG4 against foods. An open food challenge was carried out for all IgG4-positive food. All positive open tests were controlled by double-blind placebo-controlled food challenge. Results: Forty-five patients (62%) were IgG4 positive for a number of foods, mainly egg, milk, casein and wheat. None of the patients with IgG4-positive testing showed adverse reactions, neither immediate nor delayed, to the corresponding food. Conclusions: In adult patients, testing for specific IgG4 lacks clinical utility for the diagnosis of food allergy or intolerance. Dosing of IgG4 should not be part of the diagnosis and therapy of adult patients with allergy-like skin diseases.

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SHORT-TERM ANAPHYLACTIC IgG ANTIBODIES IN HUMAN SERA

Cited by 275 publications

References 7 publications

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Dextran-induced Anaphylactoid Reactions in Man

Food-Specific IgG4 Lack Diagnostic Value in Adult Patients with Chronic Urticaria and Other Suspected Allergy Skin Symptoms

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