Short-Term and Long-Term Considerations in the Management of Psoriasis with Retinoids

Goldfarb, Michael; Ellis, Charles N.; Voorhees, John J.

doi:10.1159/000248866

Cited by 5 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, cost effectiveness varies according to the outcome that is measured. Retinoids [17] by themselves, with no additional therapy, are generally ineffective for most forms of psoriasis. Required doses cause significant side effects, such as hair loss, nail thinning, dried and chapped mucous membranes and skin, and hyperlipidemia [18].…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of different therapeutic modalities in psoriasis by Pasi score

Puri¹,

Mahajan²,

Sandhu³

2013

Our Dermatol Online

View full text Add to dashboard Cite

Psoriasis is a chronic recurrent papulosquamous disorder characterized by epidermal hyperplasia. The management of psoriasis can be challenging. Although, there are many therapeutic modalities available but still there are no clear cut guidelines regarding the usage of different modalities depending on the severity of psoriasis evaluated by PASI score. Taking this into consideration, a randomized controlled trial was undertaken to clinically evaluate different therapeutic modalities in psoriasis by PASI scoring. We selected fifty clinically diagnosed cases of psoriasis and confirmed by histopathology. The patients were put on different modalities depending on the psoriasis area and severity index score (PASI score) and all the patients were followed up to 24 weeks for any relapse.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of different therapeutic modalities in psoriasis by Pasi score

Puri¹,

Mahajan²,

Sandhu³

2013

Our Dermatol Online

View full text Add to dashboard Cite

show abstract

“…Virtually all patients develop xerosis, cheilitis, peeling palms and soles, and dryness of mucous membranes (Goldfarb et al 1987). These may be troublesome, but are rarely severe enough to require the discontinuation of therapy; the frequent application of an emollient usually controls these effects.…”

Section: Cutaneous Adverse Effectsmentioning

confidence: 99%

Pharmacokinetics and Therapeutic Efficacy of Retinoids in Skin Diseases

Larsen

Nielsen‐Kudsk

Jakobsen

et al. 1992

Clinical Pharmacokinetics

View full text Add to dashboard Cite

The retinoids are a class of compounds that includes the natural forms and synthetic analogues of vitamin A. Isotretinoin, often referred to as a first generation retinoid, may be of considerable benefit to patients with severe, recalcitrant acne. Etretinate and acitretin, 2 aromatic compounds representing the second generation, have found their major success in the treatment of psoriasis, particularly in combination with more traditional therapies. Retinoid therapy is associated with a distinctive adverse effect profile typical of hypervitaminosis A; thus, it is especially important that fertile women undergoing retinoid therapy adhere to a contraceptive regimen. These drugs are extensively metabolised and only traces of unchanged drugs are eliminated in urine. The terminal elimination half-lives of isotretinoin, etretinate and acitretin after long term treatment are up to 20h, 120 days and 48h, respectively. Because of lack of definite correlation between plasma concentration and desired pharmacological effects, in conjunction with the very pronounced inter- and intraindividual variation in systemic availability (15 to 90%) after oral administration of these drugs, initial dosages in individual patients can only be roughly judged on the basis of the general pharmacokinetics of the agents. Later dosage adjustments should be made on the basis of monitoring of both plasma drug (and possible metabolite) concentrations, and the efficacy and tolerability of the drugs.

show abstract

An approach to the treatment of moderate to severe psoriasis with rotational therapy

Weinstein¹,

White²

1993

Journal of the American Academy of Dermatology

133

View full text Add to dashboard Cite

Short-Term and Long-Term Considerations in the Management of Psoriasis with Retinoids

Cited by 5 publications

References 21 publications

Clinical evaluation of different therapeutic modalities in psoriasis by Pasi score

Clinical evaluation of different therapeutic modalities in psoriasis by Pasi score

Pharmacokinetics and Therapeutic Efficacy of Retinoids in Skin Diseases

An approach to the treatment of moderate to severe psoriasis with rotational therapy

Contact Info

Product

Resources

About