Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini, Ami R.; Wallace, James S.; Nukavarapu, Syam P.

doi:10.1615/jlongtermeffmedimplants.v21.i2.10

Cited by 145 publications

(91 citation statements)

References 164 publications

(189 reference statements)

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“…It is a challenging topic and several secrets remain that might revolutionize various biomedical implants currently in clinical use (Witte, 2015). These non-permanent, biodegradable implants have been in clinical use for nearly three decades, competing directly with permanent implants (Amini et al, 2011). Biodegradable orthopedic implants, have their associated short-and long-term inflammatory effects, (Amini et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…These non-permanent, biodegradable implants have been in clinical use for nearly three decades, competing directly with permanent implants (Amini et al, 2011). Biodegradable orthopedic implants, have their associated short-and long-term inflammatory effects, (Amini et al, 2011). Although traditional permanent implants have their drawbacks, they have been proved clinically efficacious.…”

Section: Introductionmentioning

confidence: 99%

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Stress Analysis of an Artificial Human Elbow Joint: Application of Finite Element Analysis

Armah¹

2018

American Journal of Engineering and Applied Sciences

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The elbow joint is frequently affected by two kinds of arthritis (degenerative arthritis and rheumatoid arthritis) following some kind of injuries. There have been efforts since the eighteenth century by various individuals and organizations in modeling permanent implants for the elbow joint, but some of the prostheses have been disappointing because of lack of understanding of the biomechanics of the elbow joint. This paper presents investigation of the stress analysis of the fixation of artificial elbow joint into the humerus bone of the human arm. The Finite Element Analysis (FEA) technique is used to study the stress distribution. The Amira software is used to develop the humerus bone model from a Computed Tomography (CT) data set. Then, the MSC Marc Mentat software is used to create implant and cement-mantle models from geometrical entities. The Magics software is used alongside to achieve appropriate models for the analysis. The maximum principal and von Mises stresses are obtained for varying lengths of the implant at a fixed diameter and with the elbow at an angle of fixation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stress Analysis of an Artificial Human Elbow Joint: Application of Finite Element Analysis

Armah¹

2018

American Journal of Engineering and Applied Sciences

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“…Without additional surgeries, patients can experience decreased costs and recovery time, reducing the impact and stress of their treatment (Amini et al, 2011).…”

Section: Biodegradationmentioning

confidence: 99%

“…They also provide a platform for drug and growth factor delivery to the defect site to assist the healing process and prevent infections (Amini et al, 2011). 4.…”

Section: Biodegradable Tissue Engineered Implants Minimize the Risk Omentioning

confidence: 99%

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[leave for Adam - copyright supporting evidence]Designing patient-specific melt-electrospun scaffolds for bone regeneration

Paxton¹

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Biofabrication, or the 3D printing of biological-relevant tissues, is revolutionising our ability to treat patients who have suffered tissue loss as a result of trauma, disease or birth defect. As a subset of the Tissue Engineering field, biofabrication research is focussing on optimising the fabrication of implantable constructs, known as scaffolds, which provide a support structure for cell infiltration and growth, ultimately dissolving and restoring tissue, completely healing the patient.While research has focused on developing the mechanical capability to print structures using 3D printing, alongside biological advances to create highly biocompatible, bioactive constructs which have enhanced regenerative properties, less research has focused on developing methods of designing scaffolds which are anatomically matched to individual patients.In this thesis, a novel method for designing patient-specific scaffold for bone regeneration, to be fabricating using the melt-electrospinning 3D printing technique, was developed. The method was then applied to three clinically-relevant case studies, examining how to accurately design scaffolds to treat a wide range of orthopaedic injuries. Medical scan data was obtained from two patients and a third defect was recreated from an anatomical skull model. Following data acquisition, scaffolds were designed using 3D modelling software and processed into slices. These slices were processed by a proprietary g-code generation program which automatically generates the required computer instructions to fabricate each of the suitable layers using a meltelectrospinning machine. A skull scaffold to treat a large cranial defect, a femur scaffold to fill a void after a realignment procedure and a patella scaffold to improve the external shape of the reconstructed bone were successfully designed. The computer instructions were then trialled on the melt-electrospinning machine to assess the success of the generated g-code.In collaboration with the Biofabrication and Tissue Morphology group at the Queensland University of Technology, as well as the Orthopaedic Unit at the Royal Brisbane Hospital, this research project has successfully demonstrated the ability to fabricate patient-specific scaffolds, which one day could be used clinically to treat patients suffering from bone loss.

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Medical Applications

Suzuki¹,

Ikada²

2022

Poly(Lactic Acid)

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Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Cited by 145 publications

References 164 publications

Stress Analysis of an Artificial Human Elbow Joint: Application of Finite Element Analysis

Stress Analysis of an Artificial Human Elbow Joint: Application of Finite Element Analysis

[leave for Adam - copyright supporting evidence]Designing patient-specific melt-electrospun scaffolds for bone regeneration

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