“…The PRISMA flow chart for trial selection is given in Figure 1 . The included trials were conducted in USA ( 22 , 23 , 27 , 30 , 35 , 36 , 41 , 44 , 46 ), Italy ( 24 ), Spain ( 25 , 40 ), Korea ( 26 , 31 , 34 , 43 ), Japan ( 28 , 37 ), Canada ( 32 , 33 , 45 ), Israel ( 29 , 42 ), Australia ( 38 ) and UK ( 38 , 39 ). The number of patients who were involved varies between the trials ranging between 33 ( 44 ) to 2,704 ( 26 ).…”