Short‐term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis

Mestnik, Maria Josefa; Feres, Magda; Figueiredo, Luciene Cristina; Duarte, Poliana Mendes; Lira, Eisla Alline Gomes; Faveri, Marcelo

doi:10.1111/j.1600-051x.2010.01538.x

Cited by 153 publications

(310 citation statements)

References 49 publications

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“…The samples were analyzed for 40 oral bacterial species using the Checkerboard DNA-DNA Hybridization technique. 28,29 c. Checkerboard DNA-DNA hybridization: the samples were boiled for 10 min. and neutralized using 0.…”

Section: Microbiological Proceduresmentioning

confidence: 99%

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

et al. 2017

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The aim of this randomized, single blinded clinical trial was to evaluate the effect of a pre-procedural mouthwash containing cetylpyridinium chloride (CPC), zinc lactate (Zn) and sodium fluoride (F) in the reduction of viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler. Sixty systemically healthy volunteers receiving dental prophylaxis were randomly assigned to one of the following experimental groups (15 per group): (i) rinsing with 0.075% CPC, 0.28% Zn and 0.05% F (CPC+Zn+F), (ii) water or (iii) 0.12% chlorhexidine digluconate (CHX), and (iv) no rinsing. Viable bacteria were collected from different locations in the dental office on enriched TSA plates and anaerobically incubated for 72 hours. The colonies were counted and species were then identified by Checkerboard DNA-DNA Hybridization. The total number of colony-forming units (CFUs) detected in the aerosols from volunteers who rinsed with CPC+Zn+F or CHX was statistically significantly (p<0.05) lower than of those subjects who did not rinse or who rinsed with water. When all locations were considered together, the aerosols from the CPC+Zn+F and CHX groups showed, respectively, 70% and 77% fewer CFUs than those from the No Rinsing group and 61% and 70% than those from the Water group. The mean proportions of bacterial species from the orange complex were statistically significantly (p<0.05) lower in aerosols from the CPC+Zn+F and CHX groups compared with the others two groups. In conclusion, the mouthwash containing CPC+Zn+F, is effective in reducing viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler.

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Section: Microbiological Proceduresmentioning

confidence: 99%

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

et al. 2017

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“…6 Two subjects, one from the test group and one from the control group, reported adverse events (diarrhoea and vomiting) during the study. No statistically significant differences were observed between the groups with regard to the number of subjects reporting adverse events.…”

Section: Resultsmentioning

confidence: 99%

Does adjunctive use of metronidazole plus amoxicillin benefit patients receiving non-surgical scaling and root planing for the treatment of generalised aggressive periodontitis?

Zyl

Hartshorne

Carrasco‐Labra

2013

Open Journal of Implant Dentistry

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How to cite this article:This article describes a double-blinded, placebo-controlled randomised clinical trial that involved 30 eligible subjects experiencing generalised aggressive periodontitis. Subjects were randomly assigned to either the test group (scaling and root planning + metronidazole [400 mg]) and amoxicillin [500 mg]) or the control group (scaling and root planning without the adjunctive antibiotics combination). Both antibiotics and placebos were administered three times per day for 14 days. Participants were examined at baseline, and again six months and one year after therapy. Both therapies led to a statistically significant improvement in all clinical parameters as measured after one year. However, subjects who received the metronidazole-amoxicillin combination showed the greatest reduction in mean probing depth, an improved clinical attachment level and a lower mean number of residual sites after one year. The investigators concluded that the non-surgical treatment of generalised aggressive periodontitis was markedly improved by the adjunctive use of metronidazole and amoxicillin up to one year after treatment. Focus article

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“…Another point in the studies analyzed concerns the changes in microbiological profile provided by amoxicillin + metronidazole. Valenza et al 37 found no change in the subgingival microbiota of patients with AP after 12 months, however, most of the studies relates a favorable change in the microbiological profile of patients who use these antimicrobial association [38][39] . In addition, all report favorable clinical results (no control group) or better than conventional treatment [38][39] .…”

Section: Antibioticsmentioning

confidence: 99%

“…Valenza et al 37 found no change in the subgingival microbiota of patients with AP after 12 months, however, most of the studies relates a favorable change in the microbiological profile of patients who use these antimicrobial association [38][39] . In addition, all report favorable clinical results (no control group) or better than conventional treatment [38][39] . When this association (amoxicillin + metronidazole) was compared with another protocol (doxycycline), both provided improvement in clinical and microbiological parameters in 3 months follow-up 40 .…”

Section: Antibioticsmentioning

confidence: 99%

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Ayub

Júnior

Grisi

et al. 2015

RGO, Rev. Gaúch. Odontol.

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Aggressive periodontitis, a distinct clinical entity of periodontal disease, is characterized by a pronounced episodic and rapid destruction of periodontal tissues and may result in rapid and RESUMOA periodontite agressiva, uma entidade clínica distinta da doença periodontal, é caracterizada por uma pronunciada destruição episódica e rápida dos tecidos periodontais e pode resultar em perda rápida e precoce dos dentes. Alguns trabalhos têm mostrado que o debridamento mecânico convencional juntamente com higiene oral muitas vezes não é suficiente para o controle da doença. Apesar de não existir consenso, estudos recentes desta condição mostram efeitos benéficos de terapias auxiliares ou coadjuvantes como a administração de antimicrobianos sistêmicos e locais. Entre os coadjuvantes locais, a literatura apresenta os antissépticos, antibióticos e terapia fotodinâmica. Dentre os sistêmicos são representados os antibióticos e antiinflamatórios. Independentemente dos resultados apresentados por cada um deles, se reconhece a dificuldade em se estabelecer um protocolo único para todos os casos em função da resposta individual apresentada por cada paciente. O objetivo do presente estudo foi revisar os resultados atuais sobre administração de coadjuvantes químicos associados à terapia convencional em casos de periodontite agressiva e sugerir protocolos clínicos.Termos de indexação: Periodontite agressiva. Antibacterianos. Anti-infecciosos locais. Antissépticos bucais. Anti-inflamatórios. Fotoquimioterapia. and alveolar bone destruction and c) family concentration of cases. The diagnosis of AP requires the exclusion of systemic diseases that may harm the host defense and lead to premature teeth loss (periodontal manifestations of systemic diseases). Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspectsThe existence of particular forms of AP was also recognized based on specific clinical and lab characteristics: localized aggressive periodontitis (LAP) and generalized aggresssive periodontitis (GAP) 2 .A successful treatment of AP is dependent of early diagnosis, directing the therapy to the elimination or deletion of pathogens, providing a favorable

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Short‐term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis

Abstract: Subjects with GAgP significantly benefit from the adjunctive use of MTZ and AMX. The short-term advantages are observed in the clinical and microbiological parameters.

Cited by 153 publications

References 49 publications

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

Does adjunctive use of metronidazole plus amoxicillin benefit patients receiving non-surgical scaling and root planing for the treatment of generalised aggressive periodontitis?

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

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