Short-Term Bioeffects of Extracorporeal Shockwave Lithotripsy

Akdaş, Atıf; Türkeri, Levent; Ilker, Y; Şimşěk, Ferruh; Emerk, Kaya

doi:10.1089/end.1994.8.187

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…A longer period was necessary for these levels to return to normal. These findings are concordant with previous studies [20,23,25].…”

Section: Eswl Associated Injurysupporting

confidence: 94%

“…The plasma level of β 2 ‐microglobulin, which is synthesised by different cell types, such as lymphocytes, was used as a marker of renal damage. Several studies have shown an increase in β 2 ‐microglobulin after treatment with ESWL . Nevertheless, the primary early marker of renal damage is elevated urine albumin secretion even without an accompanying decrease in GFR .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown an increase in β2-microglobulin after treatment with ESWL [23]. Nevertheless, the primary early marker of renal damage is elevated urine albumin secretion even without an accompanying decrease in GFR [24].…”

Section: Eswl Associated Injurymentioning

confidence: 99%

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The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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These results are protected by a patent at the Spanish Office of Patents and Trademarks (Reference: P201131992) Objective• To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL). Patients and Methods• Prospective, randomised, double-blind, placebo-controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL.• The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after.• Renal dysfunction markers, vasoactive hormones, oxidative stress, plasma levels of several interleukins and vascular resistance index (VRI) using Doppler ultrasound were evaluated the week before ESWL, 2 h before ESWL and at 2 h, 24 h and 7 days after ESWL. Results• There was a significant increase in glomerular filtration (P = 0.013), as well as a decrease in the albumin/creatinine ratio and the β2-microglobulin level (P = 0.02) after 1 week of treatment in the CoQ10 group. These changes were maintained at the follow-up after ESWL.• The administration of CoQ10 was associated with improvement in vasoactive hormone parameters, VRI and interleukin levels. These improvements were maintained until the end of the follow-up period.• However, the administration of CoQ10 was not associated with significant changes in the oxidative stress parameters. Conclusion• Our results indicate that CoQ10 administration improves renal function and vasoactive and inflammation parameter values, allowing for preconditioning before the tissue insult caused by ESWL.

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“…A longer period was necessary for these levels to return to normal. These findings are concordant with previous studies [20,23,25].…”

Section: Eswl Associated Injurysupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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“…Puesto que las distintas enzimas se correlacionan de forma específica con distintos tipos celulares del tejido renal, los cambios en su concentración urinaria pueden ser orientativos hacía la localización de las lesiones. Algunos de estos marcadores han sido aplicados hasta el momento para evaluar la incidencia de lesión renal post litotricia: alanina aminotransferasa (ALT), aspartato aminotransferasa (AST), ß 2 microglobulina, Gamma glutamil transpepsidasa (GGT), lactato deshidrogenasa (LDH), N-acetil glucosamina, alanino aminopeptidasa (AAP), acetil colinesterasa, leucina aminopeptidasa (LAP), kalicreina y ß galactosidasa, son algunos ejemplos 5 .…”

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Estudio comparativo del daño renal producido tras la litotricia según la localización litiásica

et al. 2005

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Introducción: La litroticia por ondas de choque (LEOC) es fundamental en el tratamiento de las litiasis. Sin embargo, existen evidencias de que puede producir daño renal. El objetivo de nuestro estudio es determinar el grado de afectación de la función glomerular y tubular tras LEOC, y si influye la localización litiásica en el tipo de daño renal.Material y métodos. Se realizó un estudio longitudinal prospectivo en 14 pacientes con función renal normal sometidos a LEOC. Se determinó el nivel basal, y a las 24 horas, al 4º y al 10º día post LEOC, de microalbuminuria (MA) (que valora la función glomerular), y de N-acetil glucosamida (NAG) y la alanina aminopeptidasa (AAP) (que valoran la función tubular).Resultados: Los niveles de basales de MA, NAG y AAP no mostraron diferencias significativas en relación con la localización de los cálculos. Se observó un aumento significativo de los tres parámetros sólo a las 24 horas post LEOC. No se observaron diferencias significativas en la variación de los niveles de microalbuminuria, AAP y NAG con el tratamiento en relación a la localización de los cálculos.Conclusiones: Existe un daño glomerular y tubular tras LEO. Este daño es independiente de la localización pélvica o calicial del cálculo. En pacientes con función renal normal previa, el daño renal se recupera al 4º día post LEOC. ABSTRACT A COMPARATIVE STUDY OF THE RENAL DAMAGE PRODUCED AFTER THE EXTRACORPOREAL SHOCK WAVELITHOTRIPSY ACCORDING TO THE LITHIASIS LOCATION Introduction: The Extracorporeal shock waves lithotripsy (ESWL) is fundamental in the treatment of lithiasis. However, there are evidences that it can produce renal damage. The objective of our study is to determine the degree of affectation of the glomerular and tubular function after LEOC, and the influence of the lithiasis location on the type of renal damage.Material and methods: A prospective longitudinal study was carried out in 14 patients with normal renal function subjected to ESWL. We determined the basal level, and the levels at the 24 hours, at the 4th and the 10th day post ESWL of: microalbuminuria (MA) (that values the glomerular function), and N-acetil glucosamide (NAG) and alanine aminopeptidase (AAP), (that value the tubular function).Results: The basal levels of of MA, NAG and AAP didn't show significant differences in connection with the localization of the stones. A significant increase was observed of the three parameters only 24 hours post ESWL No significant differences were observed between the variation of the microalbuminuria levels, AAP and NAG and the treatment in relation to the localization of the stones.Conclusions: It exists a glomerular and tubular damage after ESWL. This damage is not related with the pelvic or calicial location of the stones. In patient with previous normal renal function, the renal damage recovers at the 4º day post ESWL.

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“…Puesto que las distintas enzimas se correlacionan de forma específica con distintos tipos celulares del tejido renal, los cambios en su concentración urinaria pueden ser orientativos hacía la localización de las lesiones. Algunos de estos marcadores han sido aplicados hasta el momento para evaluar la incidencia de lesión renal post litotricia: alanina aminotransferasa (ALT), aspartato ami-notransferasa (AST), ß 2 microglobulina, Gamma glutamil transpepsidasa (GGT), lactato deshidrogenasa (LDH), N-acetil glucosamina, alanino aminopeptidasa (AAP), acetil colinesterasa, leucina aminopeptidasa (LAP), kalicreina y ß galactosidasa, son algunos ejemplos 5 .…”

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Estudio comparativo del daño renal producido tras la litotricia según la localización litiásica

Gil

Rodríguez

Chamorro

et al. 2005

Actas Urológicas Españolas

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Short-Term Bioeffects of Extracorporeal Shockwave Lithotripsy

Cited by 9 publications

References 25 publications

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

Estudio comparativo del daño renal producido tras la litotricia según la localización litiásica

Estudio comparativo del daño renal producido tras la litotricia según la localización litiásica

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