Short-term biological effects of zoledronic acid combined with letrozole in postmenopausal women with estrogen receptor-positive invasive breast cancer
Abstract:e11625 Background: Aromatase inhibitors (AIs) reduce tumor cell proliferation and improve breast cancer survival. Recent evidence from in vivo models and the ABCSG-12 Trial suggests that bisphosphonates such as zoledronic acid add to the inhibitory effect of AIs but the mechanism is unclear. We assessed the effect of letrozole alone and in combination with zoledronic acid in a 14 day pre-surgical study in women with primary breast cancer. Methods: Postmenopausal women (n=109) aged 50–75 years with untreated e… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.