Short-term blood pressure variability, arterial stiffness, and cardiovascular events: results from the Bordeaux cohort

Crémer, Antoine; Doublet, Jean‐Dominique; Boulestreau, Romain; Gaudissard, Julie; Tzourio, Christophe; Gosse, Philippe

doi:10.1097/hjh.0000000000002735

Cited by 13 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…asleep BP variability is less likely to be influenced by activities such as physical activity, stressful situations, and other environmental factors [54]; thus, it is more likely to reproduce actual BP variability and better reflect the mechanisms involved in BP regulation. Several observational studies reported the impact of asleep SBP variability on future CVDs [19][20][21], which may be explained in part by its association with subclinical atherosclerosis, including AVC or CAC. Nonetheless, the exact mechanism that could explain our findings is unclear; further research is warranted to confirm these observed relationships.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the association between ambulatory BP and CAC have yielded conflicting results; some suggest an association with systolic BP (SBP) alone [16], with diastolic BP (DBP) alone [17], or with both SBP and DBP [18]. Moreover, independent of absolute ambulatory BP levels, awake or asleep BP variability, based on ambulatory BP measurements, has a prognostic implication for CVDs [19][20][21], although its association with AVC or CAC remains unknown.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of ambulatory blood pressure with aortic valve and coronary artery calcification

Sawayama¹,

Hisamatsu

Kadota

et al. 2022

Journal of Hypertension

View full text Add to dashboard Cite

We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. Methods:In this population-based, cross-sectional study, we assessed office BP, mean ambulatory BP (24-h, awake, and asleep), and variability of ambulatory BP, as determined by the coefficient of variation (awake and asleep). AVC and CAC were quantified using an Agatston score (>0) based on computed tomography scanning. We calculated relative risks (RRs) and 95% confidence intervals (CIs) with a 1-standard deviation increment in each BP index for the presence of AVC and CAC using a multivariate-adjusted Poisson regression with robust error variance.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of ambulatory blood pressure with aortic valve and coronary artery calcification

Sawayama¹,

Hisamatsu

Kadota

et al. 2022

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…A key mechanism through which OSA and cardiovascular risk may be related is via increased day-to-day blood pressure variability 20 , 21 , 26 . Blood pressure variability has been associated with an increased risk of cardiovascular events, all-cause mortality, vascular organ damage, atrial fibrillation, and dementia 15 – 19 , 27 . Consistent with the current findings of increased blood pressure in those with severe or variable OSA, day-to-day blood pressure variation of similar magnitude to the current study is associated with increased all-cause mortality and non-fatal and fatal cardiovascular events 28 .…”

Section: Discussionmentioning

confidence: 99%

High night-to-night variability in sleep apnea severity is associated with uncontrolled hypertension

et al. 2023

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) severity can vary markedly from night-to-night. However, the impact of night-to-night variability in OSA severity on key cardiovascular outcomes such as hypertension is unknown. Thus, the primary aim of this study is to determine the effects of night-to-night variability in OSA severity on hypertension likelihood. This study uses in-home monitoring of 15,526 adults with ~180 nights per participant with an under-mattress sleep sensor device, plus ~30 repeat blood pressure measures. OSA severity is defined from the mean estimated apnea–hypopnoea index (AHI) over the ~6-month recording period for each participant. Night-to-night variability in severity is determined from the standard deviation of the estimated AHI across recording nights. Uncontrolled hypertension is defined as mean systolic blood pressure ≥140 mmHg and/or mean diastolic blood pressure ≥90 mmHg. Regression analyses are performed adjusted for age, sex, and body mass index. A total of 12,287 participants (12% female) are included in the analyses. Participants in the highest night-to-night variability quartile within each OSA severity category, have a 50–70% increase in uncontrolled hypertension likelihood versus the lowest variability quartile, independent of OSA severity. This study demonstrates that high night-to-night variability in OSA severity is a predictor of uncontrolled hypertension, independent of OSA severity. These findings have important implications for the identification of which OSA patients are most at risk of cardiovascular harm.

show abstract

“…To our knowledge, this is the first study showing a positive impact of an exercise training modality on short-term BPV in women. This result appears to have potential implications in the clinical practice: an elevated BPV has been associated with an increased risk of cardiovascular events in patients with already diagnosed CAD [ 23 , 24 ]. Regarding diastolic short-term BPV, its prognostic role has also been underlined recently: in a study involving more than 9000 subjects with hypertension, diastolic short-term BPV was directly and independently related to cardiovascular mortality across all ages [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Concurrent Aerobic Plus Resistance Training on Blood Pressure Variability and Blood Pressure Values in Patients with Hypertension and Coronary Artery Disease: Gender-Related Differences

Caminiti

Perrone²,

Volterrani³

et al. 2022

JCDD

View full text Add to dashboard Cite

The purpose of this study was to compare changes in blood pressure variability (BPV) and blood pressure (BP) values occurring in response to concurrent training (CT) between the two genders. A total of 35 males and 20 women aged 55–80 years, with hypertension and coronary artery disease, were included. They underwent a 12-week CT program. The aerobic component of CT was performed according to the rate of perceived exertion while the intensity of the resistance component was set at 60% of 1 repetition maximum for the first 4 weeks and then increased to 80%. BP and BPV were evaluated at baseline and at the end of the CT program through 24 h ambulatory blood pressure monitoring. After 12-weeks, 24 h and daytime systolic BPV decreased in both men and women without significant between-groups differences. Twenty-four-hour daytime and nighttime diastolic BPV decreased in both genders with a significantly greater decrease in women compared to men. Twenty-four-hour daytime systolic and 24 h diastolic BP decreased in men while they were unchanged in women. In conclusion, CT induced similar reductions of systolic BPV in men and women and a greater decrease in diastolic BPV in women. Conversely, CT decreased BP values in males but not in females. CT appears to be an effective intervention for reducing BPV in both genders.

show abstract

Short-term blood pressure variability, arterial stiffness, and cardiovascular events: results from the Bordeaux cohort

Abstract: Supplemental Digital Content is available in the text

Cited by 13 publications

References 22 publications

Association of ambulatory blood pressure with aortic valve and coronary artery calcification

Association of ambulatory blood pressure with aortic valve and coronary artery calcification

High night-to-night variability in sleep apnea severity is associated with uncontrolled hypertension

Effects of Concurrent Aerobic Plus Resistance Training on Blood Pressure Variability and Blood Pressure Values in Patients with Hypertension and Coronary Artery Disease: Gender-Related Differences

Contact Info

Product

Resources

About