2014
DOI: 10.1007/s11011-014-9578-4
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Short term cadmium administration dose dependently elicits immediate biochemical, neurochemical and neurobehavioral dysfunction in male rats

Abstract: Cadmium is a toxic environmental and industrial pollutant. Cadmium toxicity has been reported to produce biochemical and behavioral dysfunction that may cause adverse effects on several organs including the central nervous system. The present study was designed to investigate the neurotoxic effects of Cadmium Chloride (CdCl2) at three different doses by using different behavioral models. Lipid peroxidation (LPO), superoxide dismutase (SOD) and acetylcholinesterase (AChE) activities were also monitored followin… Show more

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Cited by 45 publications
(48 citation statements)
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“…Twenty-four hours after the end of the 8 weeks corresponding to the treatment period, the animals were submitted to behavioral tests at the rate of one test per day, in the following order: the Open field test (OFT), followed by the Elevated plus maze (EPM), Forced swimming test (FST), and Morris water maze test (MWM), respectively [32,33,34]. The tests were performed between 8 am and 12 am.…”
Section: Methodsmentioning
confidence: 99%
“…Twenty-four hours after the end of the 8 weeks corresponding to the treatment period, the animals were submitted to behavioral tests at the rate of one test per day, in the following order: the Open field test (OFT), followed by the Elevated plus maze (EPM), Forced swimming test (FST), and Morris water maze test (MWM), respectively [32,33,34]. The tests were performed between 8 am and 12 am.…”
Section: Methodsmentioning
confidence: 99%
“…Previous research has shown that the detoxication effects of Se on Cd-induced toxicity occurred due to the reduction of Cd accumulation in the chicken brain. 45 Our previous reports based on the interaction of Cd and Se retention indicated that Cd-induced oxidative stress caused renal injury and Se ameliorated Cd-induced nephrotoxicity, and depressed the rate of apoptosis in the chicken kidneys. 46 Se supplementation reduced Cd-induced liver histopathological changes, oxidative stress, and overexpression of NO and apoptosis.…”
Section: Discussionmentioning
confidence: 96%
“…In addition, we have performed our experiments in young mice where female mice following delivery were treated and their off-springs were tested for locomotor activity in their adulthood. Thus in the earlier studies, the various pathways causing osteomalacia may have been accelerated owing to advanced age of the subjects and increased duration of exposure In a recent study it has been reported that acute cadmium administration dose dependently increased anxiety in rats [8].…”
Section: Discussionmentioning
confidence: 99%