Short-term ceftriaxone therapy for treatment of severe non-typhoidal Salmonella enterocolitis

Ch, Chiu; Py, Lin; Mh, Wang; Lh, Su; Lin, TY

doi:10.1080/08035320310001491

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Several studies have revealed that the short-term use of ceftriaxone in pediatric patients with severe nontyphoid salmonellosis may improve the clinical course. 19,24,25 However, to the best of our knowledge, no previous study has determined whether ceftriaxone use prolongs or shortens the fecal excretion time of NTS. In the present study, although the rate of ceftriaxone use was higher in group A than group I, ceftriaxone did not shorten the fecal excretion time of NTS in the analysis.…”

Section: + Modelmentioning

confidence: 99%

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Chen

Cheng

et al. 2021

Pediatrics & Neonatology

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Background: This study investigated whether the appropriate antibiotics therapy affects the fecal excretion time in pediatric salmonellosis of different severities and explored the factors associated with the fecal excretion time of nontyphoid Salmonella. Methods: Between 2012 and 2017, admitted children with nontyphoid salmonellosis who consented to receive consecutive stool cultures every 4e7 days until 2 consecutive negative results were obtained were enrolled. Patients were stratified into no, appropriate (bacteremia or severe patients receiving antibiotics active in vitro), and inappropriate antibiotics (patients with mild or moderate severity receiving antibiotics or severe receiving antibiotics resistant in vitro) therapy groups. A previously proposed severity score was used to classify the patients into severe, moderate, and mild severity classes. The demographics, clinical manifestations, laboratory data and severity were compared among the groups. To explore the factors associated with the fecal excretion time of nontyphoid Salmonella, univariate and multivariate analyses were performed using linear regression analysis. Results: This study enrolled 126 children with nontyphoid salmonellosis; 58 and 18 in the mild and severe classes, respectively. The no, appropriate and inappropriate antibiotics therapy groups comprised 69, 24 and 33 patients, respectively. The mean fecal excretion time was 12.17 days. The appropriate antibiotics therapy group had comparable fecal excretion time with that of no antibiotics group. Age <1 year, increased white blood cell count, decreased hemoglobin, and inappropriate antibiotics therapy significantly prolonged fecal excretion time in univariate analysis (p < 0.05). The multivariate analysis showed that inappropriate * Corresponding author. No.386, Dazhong 1st Rd.

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Section: + Modelmentioning

confidence: 99%

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Chen

Cheng

et al. 2021

Pediatrics & Neonatology

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“…Antimicrobial treatment options for adults include ceftriaxone, a medically important third-generation cephalosporin, and fluoroquinolones. There are potential side effects of fluoroquinolones for paediatric patients, and hence the first choice of treatment is ceftriaxone 2 – 4 . Because fewer treatment options are available for antimicrobial-resistant Salmonella , infections with these strains are potentially more life threatening 5 .…”

Section: Introductionmentioning

confidence: 99%

Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle

Ohta

Norman

Norby

et al. 2017

Sci Rep

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A randomized controlled longitudinal field trial was undertaken to assess the effects of injectable ceftiofur crystalline-free acid (CCFA) versus in-feed chlortetracycline on the temporal dynamics of Salmonella enterica spp. enterica in feedlot cattle. Two replicates of 8 pens (total 176 steers) received one of 4 different regimens. All, or one, out of 11 steers were treated with CCFA on day 0 in 8 pens, with half of the pens later receiving three 5-day regimens of chlortetracycline from day 4 to day 20. Salmonella was isolated from faecal samples and antimicrobial susceptibility was analysed via microbroth dilution. Serotype was determined by whole-genome sequencing. On day 0, mean Salmonella prevalence was 75.0% and the vast majority of isolates were pansusceptible. Both antimicrobials reduced overall prevalence of Salmonella; however, these treatments increased the proportion of multi-drug resistant (MDR) Salmonella from day 4 through day 26, which was the last day of faecal collection. Only six Salmonella serotypes were detected. Salmonella serotype Reading isolates were extensively MDR, suggesting a strong association between serotype and resistance. Our study demonstrates that the selection pressures of a 3rd generation cephalosporin and chlortetracycline during the feeding period contribute to dynamic population shifts between antimicrobial susceptible and resistant Salmonella.

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“…Additionally, the clinical resolution of symptoms is typically slower with ceftriaxone than with ciprofloxacin, and more severe cases may require courses longer than five days. The effectiveness of ceftriaxone has been demonstrated in the treatment of both typhoid [95] and non-typhoid salmonellosis [96] and shigellosis [83,97], even with strains resistant to fluoroquinolones [98,99]. Besides the need for parenteral administration and the high cost, the major drawback of the widespread empirical use of ceftriaxone for the treatment of acute infectious diarrhea is the immediate danger of increasing microbial resistance to this useful drug.…”

Section: Third Generation Cephalosporinsmentioning

confidence: 99%

Antibiotics for the empirical treatment of acute infectious diarrhea in children

Diniz-Santos¹,

Silva²,

Silva³

2006

Braz J Infect Dis

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While the routine use of antibiotics for infectious diarrhea in children must be avoided, because it brings little benefit in most cases and is associated with the risk of increasing antimicrobial resistance, selected cases may require antimicrobial therapy, and the choice of the antimicrobial agent often has to be made empirically. Physicians prescribing antimicrobials in such a setting have not only to be aware of the most likely pathogens, but also of their characteristic antimicrobial susceptibility pattern and the safety profile of the various drugs. We reviewed the literature on the use of ampicillin, beta-lactamase inhibitors, trimethoprim-sulfamethoxazole, chloramphenicol, tetracyclines, nalidixic acid, fluoroquinolones, third-generation cephalosporins, macrolides, metronidazole and malabsorbed agents in the setting of acute infectious diarrhea, and we evaluated the available information, seeking to apply it to empirical use, highlighting clinically-useful pharmacological information and patients' and pathogens' characteristics that must be taken into account for decisions about antimicrobial therapy.

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Short-term ceftriaxone therapy for treatment of severe non-typhoidal Salmonella enterocolitis

Cited by 3 publications

References 13 publications

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle

Antibiotics for the empirical treatment of acute infectious diarrhea in children

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