Short-term changes of serum concentrations of IL-6 induced byinterferon alfa-2b in patients with chronic hepatitis C. preliminaryreport

Cocaine Dependence and Acute Cocaine Induce Decreases of Monocyte Proinflammatory Cytokine Expression across the Diurnal Period: Autonomic Mechanisms

“…IL-6 has antiviral activity and plays a role in hepatitis C clearance; circulating levels of IL-6 correlate with viral clearance during hepatitis C infection, and replication of hepatitis C RNA can be significantly suppressed by IL-6 (Zhu et al, 2004). Moreover, circulating levels of IL-6 are lower in hepatitis C-infected persons compared with hepatitis C-negative controls (Lee et al, 2002), and levels IL-6 are higher in patients who respond to interferon-␣ treatment (Mazur et al, 2001). Likewise, a decrease in the ability of monocytes to express IL-6 may also have implications for primary and early HIV infection (Chaisson et al, 1989;Anthony et al, 1991;Deeks et al, 2004).…”

Is interleukin-8 an additional to histopathological changes diagnostic marker in HCV-infected patients with cryoglobulinemia?

“…On the other hand, serum cytokine levels may be correlated with their production in the liver [10]. It has also been shown that IFN therapy caused a short-term increase (up to 24 h) of cytokines [15,16]. Because the patients enrolled in this study were not under IFN/ribavirin therapy for 1 year prior to the liver biopsy and blood sample collection for cytokines examination, we did not analyze the influence of IFN administration on the cytokine level.…”

Avaliação tireoidiana de pacientes infectados pelo vírus da hepatite C: correlação com polimorfismos do gene CTLA4

“…A diminuição dos níveis de T3T e T4T totais poderia estar relacionada ao aumento de IL-6, decorrente do uso de IFNα [136][137][138][139][140][141] . Estudos de tratamento com IFNα convencional observaram aumento dos níveis de RNAm de IL-6 em leucócitos periféricos 137 e dos níveis séricos de IL-6 [138][139][140] .…”