Short-term cognitive training recapitulates hippocampal functional changes associated with one year of longitudinal skill development

Rosenberg‐Lee, Miriam; Iuculano, Teresa; Bae, Se Ri; Richardson, Jennifer L.; Qin, Shaozheng; Jolles, Dietsje; Menon, Vinod

doi:10.1016/j.tine.2017.12.001

Cited by 33 publications

(51 citation statements)

References 54 publications

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“…Cognitive training is commonly applied as a method of providing stimulation to different areas of the brain, and it is regarded as a promising, nonpharmacological preventative intervention in several different populations [29, 30]. This type of training for PLWD usually involves the guided practice of a set of standardized tasks to exercise the brain across various cognitive domains including processing speed, attention, and memory [31].…”

Section: Resultsmentioning

confidence: 99%

A Mini-Review of Virtual Reality-Based Interventions to Promote Well-Being for People Living with Dementia and Mild Cognitive Impairment

D’Cunha

Nguyen

Naumovski³

et al. 2019

Gerontology

176

123

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Assistive technology including virtual reality and augmented reality has gained interest as a novel intervention in a range of clinical settings. This technology has the potential to provide mental stimulation, a connection to autobiographical memory through reminiscence, and enhanced quality of life (QoL) to people living with dementia (PLWD) and mild cognitive impairment (MCI). In this mini-review, we examine the available evidence from studies reporting on the potential benefits of virtual and augmented reality to provide enjoyable, leisurely activities that may promote QoL and psychological well-being and facilitate social interaction. In total, 10 studies of varying study designs and durations (5 min to 6 months) using virtual (n = 9) and augmented reality (n = 1) were examined in PLWD (n = 6) and MCI (n= 3), in addition to 1 study that included participants with both conditions. Overall, the virtual experiences were enjoyed by the participants, improved their mood and apathy, and were preferred when compared with nonvirtual experiences. However, small sample sizes and variations in study design limit the generalizability of the results. Nevertheless, the use of virtual and augmented reality technology for PLWD and MCI is a novel and emerging method which may provide cognitive stimulation and improve well-being. Future research should explore the potential application of this technology to promote social interaction in both the community and aged care settings. We suggest future studies in PLWD and MCI assess the effects of more sustained use of virtual and augmented reality technology on psychological outcomes including QoL, apathy, and depressive symptoms, with the incorporation of physiological biomarker outcomes.

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Section: Resultsmentioning

confidence: 99%

A Mini-Review of Virtual Reality-Based Interventions to Promote Well-Being for People Living with Dementia and Mild Cognitive Impairment

D’Cunha

Nguyen

Naumovski³

et al. 2019

Gerontology

176

123

View full text Add to dashboard Cite

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“…Qin et al (2014) longitudinal study showed that 7-to 9-years-old children showed increases in hippocampus activation and decreases in prefrontalparietal activation during addition problem solving, suggesting a transition from counting to retrieval (Qin et al, 2014). Rosenberg- Lee et al (2018) found increases in hippocampus and decreases in fronto-parietal activity when children solved a single-digit addition verification task after they completed an 8-week number and arithmetic training. In summary, studies suggest an important role of the hippocampus for addition, so future studies need to address the role of this brain area in distinguishing between the Schema-based and Factretrieval hypotheses.…”

Section: The Case Of Addition: An Ongoing Debatementioning

confidence: 99%

Early Engagement of Parietal Cortex for Subtraction Solving Predicts Longitudinal Gains in Behavioral Fluency in Children

Suárez‐Pellicioni

Berteletti

Booth

2020

Front. Hum. Neurosci.

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There is debate in the literature regarding how single-digit arithmetic fluency is achieved over development. While the Fact-retrieval hypothesis suggests that with practice, children shift from quantity-based procedures to verbally retrieving arithmetic problems from long-term memory, the Schema-based hypothesis claims that problems are solved through quantity-based procedures and that practice leads to these procedures becoming more automatic. To test these hypotheses, a sample of 46 typically developing children underwent functional magnetic resonance imaging (fMRI) when they were 11 years old (time 1), and 2 years later (time 2). We independently defined regions of interest (ROIs) involved in verbal and quantity processing using rhyming and numerosity judgment localizer tasks, respectively. The verbal ROIs consisted of left middle/superior temporal gyri (MTG/STG) and left inferior frontal gyrus (IFG), whereas the quantity ROIs consisted of bilateral inferior/superior parietal lobules (IPL/SPL) and bilateral middle frontal gyri (MFG)/right IFG. Participants also solved a single-digit subtraction task in the scanner. We defined the extent to which children relied on verbal vs. quantity mechanisms by selecting the 100 voxels showing maximal activation at time 1 from each ROI, separately for small and large subtractions. We studied the brain mechanisms at time 1 that predicted gains in subtraction fluency and how these mechanisms changed over time with improvement. When looking at brain activation at time 1, we found that improvers showed a larger neural problem size effect in bilateral parietal cortex, whereas no effects were found in verbal regions. Results also revealed that children who showed improvement in behavioral fluency for large subtraction problems showed decreased activation over time for large subtractions in both parietal and frontal regions implicated in quantity, whereas non-improvers maintained similar levels of activation. All children, regardless of improvement, showed decreased activation over time for large subtraction problems in verbal regions. The greater parietal problem size effect at time 1 and the reduction in activation over time for the improvers in parietal and frontal regions implicated in quantity processing is consistent with the Schema-based hypothesis arguing for more automatic procedures with increasing skill. The lack of a problem size effect at time 1 and the overall decrease in verbal regions, regardless of improvement, is inconsistent with the Fact-retrieval hypothesis.

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“…Alternative terms included neural change, neuronal change, neural plasticity, functional connectivity, brain connectivity, experience-dependent structural change, experiencedependent plasticity, and developmental plasticity. [25][26][27][28][29][30][31][32][33][34] Furthermore, even broader terms for plasticity were used in some studies, such as neuromodulation. 35 The terminology of plasticity in studies correspondingly influenced the selection of imaging modality.…”

Section: Plasticity Terminology and Measurementmentioning

confidence: 99%

Neuroplasticity in children and adolescents in response to treatment intervention: A systematic review of the literature

Weyandt

Clarkin

Holding

et al. 2020

Clinical and Translational Neuroscience

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The purpose of the present study was to conduct a systematic review of the literature, adhering to PRISMA guidelines, regarding evidence of neuroplasticity in children and adolescents in response to cognitive or sensory-motor interventions. Twenty-eight studies employing seven different types of neuroimaging techniques were included in the review. Findings revealed that significant variability existed across the 28 studies with regard to the clinical populations examined, type of interventions employed, neuroimaging methods, and the type of neuroimaging data included in the studies. Overall, results supported that experience-dependent interventions were associated with neuroplastic changes among children and adolescents in both neurotypical and clinical populations. However, it remains unclear whether these molecular neuroplastic changes, including the degree and direction of those differences, were the direct result of the intervention. Although the findings are encouraging, methodological limitations of the studies limit clinical utility of the results. Future studies are warranted that rigorously define the construct of neuroplasticity, establish consistent protocols across measurement techniques, and have adequate statistical power. Lastly, studies are needed to identify the functional and structural neuroplastic mechanisms that correspond with changes in cognition and behavior in child and adolescent samples.

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Short-term cognitive training recapitulates hippocampal functional changes associated with one year of longitudinal skill development

Cited by 33 publications

References 54 publications

A Mini-Review of Virtual Reality-Based Interventions to Promote Well-Being for People Living with Dementia and Mild Cognitive Impairment

A Mini-Review of Virtual Reality-Based Interventions to Promote Well-Being for People Living with Dementia and Mild Cognitive Impairment

Early Engagement of Parietal Cortex for Subtraction Solving Predicts Longitudinal Gains in Behavioral Fluency in Children

Neuroplasticity in children and adolescents in response to treatment intervention: A systematic review of the literature

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