Short-term combined training reduces hepatic steatosis and improves hepatic insulin signaling

Pereira, Rodrigo Fernando; Rodrigues, Kellen Cristina da Cruz; Sant’Ana, Marcella Ramos; Peruca, Guilherme Francisco; Anaruma, Chadi Pellegrini; Campos, Thaís Dantis Pereira de; Canciglieri, Raphael dos Santos; Melo, Diego Gomes de; Simabuco, Fernando Moreira; Silva, Adelino Sánchez Ramos da; Cintra, Dennys Esper; Ropelle, Eduardo Rochete; Pauli, José Rodrigo; Moura, Leandro Pereira de

doi:10.1016/j.lfs.2021.120124

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…These results are consistent with the study of Diniz et al, in which it was reported that 8 weeks of aerobic exercise reduced the concentrations of inflammatory cytokines in the liver of NAFLD mice [ 36 ]. Pereira et al found that short-term combined aerobic and strength training can also reduce liver TNF-α protein expression in mice with hepatic steatosis [ 42 ]. The above results show that different exercise patterns can reduce liver inflammation in diet-induced hepatic steatosis mice.…”

Section: Discussionmentioning

confidence: 99%

“…It was found that only moderate-intensity exercise could reduce the expression of CD36 protein, suggesting that HIIT may not reduce liver fat content by reducing CD36 expression. In addition, previous studies have found that exercise can increase PPARα and CPT1α gene levels in obese mice [ 42 , 50 ]. In conclusion, HIIT may improve liver fat metabolism by inhibiting liver fat production and promoting liver fatty acid oxidation to reduce liver fat content in T2DM mice.…”

Section: Discussionmentioning

confidence: 99%

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HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

Wang

Guo

et al. 2022

Metabolites

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High-intensity interval training (HIIT), a new type of exercise, can effectively prevent the progression of metabolic diseases. The aim of this study was to investigate the effects of HIIT on liver inflammation and metabolic disorders in type 2 diabetes mellitus (T2DM) mice induced by a high-fat diet (HFD) combined with streptozotocin (STZ) and to explore the possible mechanisms of macrophage polarization and mitochondrial dynamics. Our results showed that HIIT can increase fatty acid oxidation-related gene (PPARα, CPT1α, and ACOX1) mRNA levels and decrease adipogenesis-related gene (PPARγ) mRNA levels to improve liver metabolism in T2DM mice. The improvement of lipid metabolism disorder may occur through increasing liver mitochondrial biosynthesis-related genes (PGC-1α and TFAM) and restoring mitochondrial dynamics-related gene (MFN2 and DRP1) mRNA levels. HIIT can also reduce the mRNA levels of liver inflammatory factors (TNF-α, IL-6, and MCP-1) in T2DM mice. The reduction in liver inflammation may occur through reducing the expression of total macrophage marker (F4/80) and M1 macrophage marker (CD86) mRNA and protein and increasing the expression of M2 macrophage marker (CD163, CD206, and Arg1) mRNA and protein in the liver. HIIT can also increase the expression of insulin signaling pathway (IRS1, PI3K, and AKT) mRNA and protein in the liver of T2DM mice, which may be related to the improvements in liver inflammation and lipid metabolism. In conclusion, these results suggested that 8 weeks of HIIT can improve inflammation and lipid metabolism disorders in the liver of type 2 diabetes mellitus mice, macrophage M1/M2 polarization, and mitochondrial dynamics may be involved in this process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

Wang

Guo

et al. 2022

Metabolites

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“… 21 , 22 In T2D/obese mice, exercise training reduced hepatic steatosis, the expression of lipogenic genes and liver inflammation, regardless of body adiposity, and increased the phosphorylation of acetyl-CoA-carboxylase and oxidative genes, reversing complications caused by T2D in the liver. 23 Furthermore, during exercise, skeletal muscles act as endocrine-like organs, producing myokines and exerting a multiorgan effect on contractile and non-contractile tissues, including liver and adipose tissue. 24 Several molecular and metabolic mechanisms seem to be involved in the benefic effects of exercise on T2D, but the underlying mechanisms contributing to improvements of microcirculation function remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2 Diabetic Mice

Rodrigues¹,

Silva²,

Pereira³

et al. 2022

DMSO

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Type 2 diabetic (T2D) patients have liver and adipose tissue microcirculation disturbances associated with metabolic dysfunction and disease progression. However, the potential role of aerobic training on hepatic and white adipose tissue (WAT) microcirculation and the underlying mechanisms have not been elucidated to date. Therefore, we investigated the role of aerobic training on liver and WAT microcirculation and AGE-RAGE modulation in T2D mice. Methods: The control group (CTL) was fed standard chow, and T2D was induced by feeding male C57BL/6 a high-fat, highcarbohydrate diet for 24 weeks. In the following 12 weeks, mice underwent aerobic training (CTL EX and T2D EX groups), or were kept sedentary (CTL and T2D groups). We assessed metabolic parameters, biochemical markers, oxidative damage, the AGE-RAGE axis, hepatic steatosis, hepatic stellate cells activation (HSC) and liver and WAT microcirculation. Results: Hepatic microcirculation was improved in T2D EX mice which were associated with improvements in body, liver and fat mass, blood pressure, hepatic steatosis and fibrosis, and decreased HSC and AGE-RAGE activation. In contrast, improvement in WAT microcirculation, that is, decreased leukocyte recruitment and increased perfusion, was associated with increased catalase antioxidant activity. Conclusion:Physical training improves hepatic and adipose tissue microcirculatory dysfunction associated with T2D, likely due to downregulation of AGE-RAGE axis, decreased HSC activation and increased antioxidant activity.

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Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats

Sheikh,

Shakerian,

Fatemi Tabatabaei

et al. 2023

Immunobiology

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Short-term combined training reduces hepatic steatosis and improves hepatic insulin signaling

Cited by 5 publications

References 43 publications

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus Mice

Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2 Diabetic Mice

Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats

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