Short-term consumption of alcohol (vodka) mixed with energy drink (AMED) attenuated alcohol-induced cerebral capillary disturbances and neuroinflammation in adult wild-type mice

Takechi, Ryusuke; Mamo, John; Das, Sukanya; Graneri, Liam; D’Alonzo, Zachary; Nesbit, Michael; Junaldi, Edwin; Lam, Virginie

doi:10.1080/1028415x.2021.1975364

Cited by 2 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, metabolization can be affected after chronic administration of the drugs. Male mice treated with AmED and EtOH for 5 days did not show a difference in BEC 30 min after administration of the drugs (Takechi et al, 2021). On the other hand, if the blood is collected immediately after the last session of a 15-day chronic self-administration protocol with ED followed by a 20-day self-administration protocol with AmED, BEC is significantly higher than those measured in animals from the EtOH + sucrose group (Roldán et al, 2017).…”

Section: Blood Ethanol Concentration (Bec)mentioning

confidence: 67%

“…No difference was found in the cortex. The AmED group presented significantly less astroglial expression, less GFAP marking in the hippocampus and a reduced expression of Iba-1 compared to EtOH alone after 5 days of treatment (Takechi et al, 2021). In contrast, after 60 days of treatment, the AmED had increased immunoreactivity to GFAP in comparison with EtOH and water control groups.…”

Section: Biochemical and Neurochemical Measuresmentioning

confidence: 82%

See 1 more Smart Citation

Ethanol combined with energy drinks: Two decades of research in rodents

Petribu

Abrahao²,

Formigoni³

2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Many studies raised concerns on alcoholic beverages consumption mixed with energy drinks (AmED), which can induce higher rates of binge drinking and earlier development of alcohol use disorders. After 20 years of research, few studies with laboratory animals have focused on the effects of this mixture and the neurobiological and pharmacological mechanisms underlying them. We found 16 articles on AmED administration to rodents evaluating its effects on voluntary consumption, locomotion, anxiety-like behavior, memory, influence on the onset time of seizures, biochemical and neurochemical measures. Some of these studies indicated energy drinks (ED) can alter the pattern of use and motivation to consume ethanol (EtOH); increase the expression of sensitization to EtOH stimulant effect and the proportion of sensitized mice; decrease the aversiveness of high concentrations of EtOH, among other effects. In addition AmED hastens the loss of righting reflex and its effects on memory are controversial. After acute administration no difference was found in blood ethanol concentration (BEC) of rodents which received EtOH with or without ED, but after 60 days of treatment, AmED group had lower BEC levels than EtOH group. Data on biochemical and neurochemical parameters after AmED are not consistent. Although the AmED group presented higher glucose levels than the EtOH group when drugs were administered by gavage, this was not observed in a self-administration protocol. AmED may induce higher kidney damage, higher levels of plasma urea, uric acid and creatinine when compared to EtOH. Chronic consumption of AmED causes an inflammatory response and oxidative stress, which may induce cell death in the cortex and hypothalamus of adult rats. These controversial results show that AmED diverse effects depend on sex, age and lineage of the animals, duration of the treatment and route of administration. Further research is necessary to evaluate the mechanisms underlying AmED biological effects.

show abstract

Section: Blood Ethanol Concentration (Bec)mentioning

confidence: 67%

Section: Biochemical and Neurochemical Measuresmentioning

confidence: 82%

Ethanol combined with energy drinks: Two decades of research in rodents

Petribu

Abrahao²,

Formigoni³

2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Pro-and anti-inflammatory cytokines did not significantly differ in mice given only EDs or alcohol mixed with EDs. Thus, the acute negative effects of alcohol on cerebral capillary integrity and astrogliosis may be paradoxically diminished by taking an ED that is high in taurine and caffeine and contains B vitamins [72]. Adolescent mice that were given EDs in addition to alcohol saw a substantially slower rate of loss of their righting reflex compared to mice that were simply given alcohol.…”

Section: Short-term Studies On Animalsmentioning

confidence: 99%

Caffeine and Taurine from Energy Drinks—A Review

Mihaiescu,

Turti,

Souca

et al. 2024

Cosmetics

View full text Add to dashboard Cite

The purpose of this paper is to review the specialized literature to highlight the effects produced by energy drinks in terms of skin health. To carry out this review, we consulted previous articles with descriptive cross-sectional designs, case series, and individual case reports published between 2000 and 2023. Therefore, while caffeine acute consumption among adults can have beneficial effects, in children, it can cause health problems like overnight breaks, headaches, and dulled cognition since their organs are still developing and their endocrine system is not yet stable. Despite the antioxidant and neuroprotective effects of caffeine from energy drinks, their excessive consumption among adolescents can cause disorders like high systolic blood pressure, agitation, nausea, anxiety, osteoporosis, heart palpitations, poor sleep quality, and stomach ulcers. Among athletes, taurine supplementation has been proven to improve exercise capacity in cold weather conditions. Also, vigilance, attention, and reaction time were all improved by caffeine consumption. Caffeine administration in low doses caused a risk of cardiovascular disease. It was effective in treating migraines in children, but raised systolic blood pressure, and contributed to skin healing in adolescents. On the other side, taurine prevents obesity among children, causes positive effects on oxidative stress and inflammation in adolescents, helps shield the skin from damaging oxidative stress among students, and impacts exercise capacity in athletes. Significant increases in serum levels of uric acid, creatinine, BUN, ALT, and ALP caused by chronic intake of EDs indicated different degrees of injury to the kidneys and liver. Furthermore, the effects on the cardiovascular system could be worse if taurine and caffeine are combined. Caffeine alone does not significantly decrease sleep as much as a taurine/high caffeine ratio. On the other hand, a low ratio does.

show abstract

Short-term consumption of alcohol (vodka) mixed with energy drink (AMED) attenuated alcohol-induced cerebral capillary disturbances and neuroinflammation in adult wild-type mice

Cited by 2 publications

References 47 publications

Ethanol combined with energy drinks: Two decades of research in rodents

Ethanol combined with energy drinks: Two decades of research in rodents

Caffeine and Taurine from Energy Drinks—A Review

Contact Info

Product

Resources

About