Short-Term Corneal Endothelial Response to Wear of Silicone-Hydrogel Contact Lenses in East Asian Eyes

Abstract

The similarity of bleb responses induced by the silicone-hydrogel lenses under the tested wearing conditions is consistent with the proposition that increases in Dk/t above a certain level will produce minimal change in corneal physiologic conditions compared with that when no lens is worn.

Have Silicone Hydrogel Lenses Eliminated Hypoxia?

“…In a contralateral study of East Asians, Brennan et al 69 found after 20 min of eye closure, significantly more blebs with low Dk lenses compared with 2 types of silicone hydrogels. In addition, under openeye conditions, two silicone hydrogel lens types produced minimal changes.…”

Endothelial blebs

“…Brennan et al 11 evaluated the corneal endothelial bleb response to wear of silicone hydrogel lenses (Acuvue Oaysis, Acuvue Advance and Focus Night & Day) and a conventional hydrogel lens (SofLens 38) in eyes of East Asian subjects. SofLens 38 produced a mean percentage area of blebs of 8.0% under closed eye conditions, which was significantly different to that produced by Acuvue Oaysis (1.6%).…”

The significance of oxygen during contact lens wear

“…The magnitude of the response has been found to associate in an inverse fashion, with the oxygen transmissibility of the lens being worn at the time [73][74][75].…”