Short-term cortical reorganization by deafferentation of the contralateral sensory cortex

Waberski, Till Dino; Dieckhöfer, A.; Reminghorst, U.; Büchner, Helmut; Gobbelé, René

doi:10.1097/wnr.0b013e3282202c1f

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…Our findings are in agreement with earlier animal and human studies showing that deafferentation is associated with changes in neuronal organization in the cortex and subcortical areas. These changes are associated with warm and referred sensations, perceptual illusions, neuropathic pain, and enhanced sensorimotor function of nondeafferented areas (Björkman et al, 2004(Björkman et al, , 2005Kanai et al, 2010;Lundborg, 2000;Mihic and Pinckert, 1981;Navarro et al, 2007;Paqueron et al, 2003;Rinaldi et al, 1991;Silva et al, 2011;Waberski et al, 2007;Weiss et al, 2004;Werhahn et al, 2002).…”

Section: Discussionmentioning

confidence: 96%

“…The authors argue that these changes are related to the loss of inhibitory influences within these brain neuronal networks. There is general agreement in the literature that deafferentation causes a rebalancing of excitatory and inhibitory neuronal activity toward disinhibition exposing formerly masked excitatory connections (Björkman et al, 2005;Faggin et al, 1997;Kaas, 1999;Nicolelis et al, 1993;Pawela et al, 2006;Seminowicz et al, 2012;Waberski et al, 2007;Weiss et al, 2007;Wernhahn et al, 2002). Krupa et al (1999) further show that also feedback from cortex to thalamus plays an important role in plastic changes due to deafferentation [see also Kaas (1999)].…”

Section: Effect Of Deafferentation On Canonical Resting-state Networkmentioning

confidence: 92%

“…Several experimental human and animal studies show that when peripheral sensory and motor input is removed (e.g., by application of ischemia or local anesthetic-induced nerve blocks, cutaneous anesthesia, or peripheral nerve damage) detectable functional changes in the cortex occur (Björkman et al, 2005;Kaas, 1999;Pawela et al, 2010;Waberski et al, 2007;Weiss et al, 2004;Wernhahn et al, 2002). Also subcortical areas, including the thalamus, show changes upon deafferentation (Faggin et al, 1997;Krupa et al, 1999;Nicolelis et al, 1993;Pawela et al, 2010).…”

Section: Introductionmentioning

confidence: 96%

“…These changes are best described as reorganization of neuronal interactions due to a rebalancing of excitatory and inhibitory factors that mediate adaptation and neuronal plasticity (Kaas, 1999). For example, the loss of sensory and motor input from the hand by peripheral nerve blockade is associated with supraspinal excitatory changes possibly mediated by disinhibition of unmasked (interhemispheric) cortical neuronal connections, and explains the enhanced functionality of the contralateral hand (Waberski et al, 2007;Weiss et al, 2004). These cortical changes coincide often with perceptual changes.…”

Section: Introductionmentioning

confidence: 97%

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Effect of Deafferentation from Spinal Anesthesia on Pain Sensitivity and Resting-State Functional Brain Connectivity in Healthy Male Volunteers

Sitsen¹,

Oudejans²,

Vuyk³

et al. 2014

Brain Connectivity

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Patients may perceive paradoxical heat sensation during spinal anesthesia. This could be due to deafferentation-related functional changes at cortical, subcortical, or spinal levels. In the current study, the effect of spinal deafferentation on sensory (pain) sensitivity was studied and linked to whole-brain functional connectivity as assessed by resting-state functional magnetic resonance imaging (RS-fMRI) imaging. Deafferentation was induced by sham or spinal anesthesia (15 mg bupivacaine injected at L3-4) in 12 male volunteers. RS-fMRI brain connectivity was determined in relation to eight predefined and seven thalamic resting-state networks (RSNs) and measured before, and 1 and 2 h after spinal/sham injection. To measure the effect of deafferentation on pain sensitivity, responses to heat pain were measured at 15-min intervals on nondeafferented skin and correlated to RS-fMRI connectivity data. Spinal anesthesia altered functional brain connectivity within brain regions involved in the sensory discriminative (i.e., pain intensity related) and affective dimensions of pain perception in relation to somatosensory and thalamic RSNs. A significant enhancement of pain sensitivity on nondeafferented skin was observed after spinal anesthesia compared to sham (area-under-the-curve [mean (SEM)]: 190.4 [33.8] versus 13.7 [7.2]; p<0.001), which significantly correlated to functional connectivity changes observed within the thalamus in relation to the thalamo-prefrontal network, and in the anterior cingulate cortex and insula in relation to the thalamo-parietal network. Enhanced pain sensitivity from spinal deafferentation correlated with functional connectivity changes within brain regions involved in affective and sensory pain processing and areas involved in descending control of pain.

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Section: Discussionmentioning

confidence: 96%

Section: Effect Of Deafferentation On Canonical Resting-state Networkmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Effect of Deafferentation from Spinal Anesthesia on Pain Sensitivity and Resting-State Functional Brain Connectivity in Healthy Male Volunteers

Sitsen¹,

Oudejans²,

Vuyk³

et al. 2014

Brain Connectivity

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show abstract

“…The commonest way used so far to assess cortical somatotopic representation changes, both in healthy subjects and patients, has been dipolar source modeling of somatosensory evoked potentials and fields (SEPs-SEFs) to face and/or upper limb stimulation Flor et al, 1995;Grü sser et al, 2001;Karl et al, 2001;Montoya et al, 1998;Rossini et al, 1998;Schaefer et al, 2002a,b;Schwenkreis et al, 2001;Soros et al, 2001;Tecchio et al, 2002;Vartiainen et al, 2009;Waberski et al, 2007]. Although ''shrinking'' of the upper limb representation, with medial displacement of the face area after amputation is often reported, the correlation between plasticity in S1 and pain remains elusive, a close correlation being observed in a number of studies Flor et al, 1995Flor et al, , 1998Grü sser et al, 2001;Karl et al, 2001;Montoya et al, 1998;Tecchio et al, 2002] but not in others [Schwenkreis et al, 2001;Vartiainen et al, 2009].…”

Section: Introductionmentioning

confidence: 99%

Cortical representation of the human hand assessed by two levels of high‐resolution EEG recordings

Houzé¹,

Perchet²,

Magnin³

et al. 2011

Human Brain Mapping

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Increasing interest in cortical plasticity has prompted the growing use of somatosensory evoked potentials (SEPs) to estimate changes in the cortical representation of body regions. Here, we tested the effect of different sites of hand stimulation and of the density of spatial sampling in the quality of estimation of somatosensory sources. Sources of two SEP components from the primary somatosensory cortex (N20/P20 and P45) were estimated using two levels of spatial sampling (64- vs. 128-channel) and stimulation of four distal sites in the upper limbs, including single digits (first vs. fifth) and distal nerves with comparable cortical projection (superficial branch of the radial nerve and distal ulnar nerve). The most robust separation of somatosensory sources was achieved by comparing the cortical representations of the first digit and the distal ulnar nerve territories on the N20/P20 component of SEPs. Although both the 64- and the 128-electrode montages correctly discriminated these two areas, only the 128-electrode montage was able to significantly separate sources in the other cases, notably when using first versus fifth digit stimulation. Trustworthy distinction of cortical representations was not obtainable when using the P45 component, probably because of greater activation volume, radial orientation of sources in areas 1-2 and increased variability with attention and vigilance. Assessment of tangential SEP components to stimulation of first digit versus ulnar nerve appears the best option to assess plastic somatosensory changes, especially when using relatively low-electrode sampling.

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Short-term cortical plasticity induced by conditioning pain modulation

et al. 2011

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To investigate the effects of homotopic and heterotopic conditioning pain modulation (CPM) on short-term cortical plasticity. Glutamate (tonic pain) or isotonic saline (sham) was injected in the upper trapezius (homotopic) and in the thenar (heterotopic) muscles. Intramuscular electrical stimulation was applied to the trapezius at pain threshold intensities, and somatosensory evoked potentials were recorded with 128 channel EEG. Pain ratings were obtained during glutamate and sham pain injection. Short-term cortical plasticity to electrical stimulation was investigated before, during, and after homotopic and heterotopic CPM versus control. Peak latencies at N100, P200, and P300 were extracted and the location/strength of corresponding dipole current sources and multiple dipoles were estimated. Homotopic CPM caused hypoalgesia (P = 0.032, 30.6% compared to baseline) to electrical stimulation. No cortical changes were found for homotopic CPM. A positive correlation at P200 between electrical pain threshold after tonic pain and the z coordinate after tonic pain (P = 0.032) was found for homotopic CPM. For heterotopic CPM, no significant hypoalgesia was found and a dipole shift of the P300 z coordinate (P = 0.001) was found between glutamate versus sham pain (P = 0.009). This generator was located in the cingulate. A positive correlation at P300 between pain ratings to glutamate injection and the x coordinate during tonic pain (P = 0.016) was found for heterotopic CPM. Heterotopic CPM caused short-term cortical plasticity within the cingulate that was correlated to subjective pain ratings. The degree of long-term depressive effect to homotopic CPM was correlated to the change in location of the P200 dipole.

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Short-term cortical reorganization by deafferentation of the contralateral sensory cortex

Cited by 13 publications

References 26 publications

Effect of Deafferentation from Spinal Anesthesia on Pain Sensitivity and Resting-State Functional Brain Connectivity in Healthy Male Volunteers

Effect of Deafferentation from Spinal Anesthesia on Pain Sensitivity and Resting-State Functional Brain Connectivity in Healthy Male Volunteers

Cortical representation of the human hand assessed by two levels of high‐resolution EEG recordings

Short-term cortical plasticity induced by conditioning pain modulation

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