Short‐term cycling restores endothelial dysfunction after resistance exercise

Morishima, Takuma; Iemitsu, Motoyuki; Ochi, Eisuke

doi:10.1111/sms.13434

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…It has been reported that 8 weeks of aerobic exercise performed after resistance exercise increased resting FMD, while the opposite (aerobic exercise performed before resistance exercise) led to an unchanged FMD (Okamoto et al, 2007). Accordingly, in sedentary subjects, aerobic exercise performed after (Morishima et al, 2019a), but not before (Morishima et al, 2019b), resistance exercise protects against the deleterious effect of resistance exercise on FMD. Whether similar FMD changes occur in endurance and resistance trained subjects is not known and deserves to be studied.…”

Section: Discussionmentioning

confidence: 97%

Post-exercise Endothelium-Dependent Vasodilation Is Dependent on Training Status

et al. 2020

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The effect of training status on post-exercise flow-mediated dilation (FMD) is not well characterized. We tested the hypothesis that the more trained the subjects, the lower the reduction in FMD after an acute bout of aerobic exercise. Forty-seven men (mean ± SD, age: 20.1 ± 1.2 years, body mass: 75.5 ± 5.1 kg, height 178.1 ± 5.4 cm) were divided into five groups with different training characteristics (sedentary, two different groups of active subjects, two different groups of well-trained subjects -runners and weightlifters). Brachial artery FMD (blood pressure cuff placed around the arm distal to the probe with the proximal border adjacent to the medial epicondyle; 5 min at a pressure of 220 mmHg) was assessed before and during 3 min immediately after a bout of cycling exercise at a relative intensity of 170 bpm [(physical work capacity (PWC 170 )]. At baseline, a progressive increase in FMD was observed in the participants with the higher training status, if the training remained moderate. Indeed, FMD was reduced in runners and weightlifters compared to those who were moderately trained. After PWC 170 , FMD did not significantly change in sedentary and highly trained runners, significantly increased in the two groups of active subjects but significantly decreased in highly trained weightlifters. These results showed that endothelium-dependent vasodilation evaluated using brachial FMD is maintained or improved following acute aerobic exercise in moderately trained participants, but not in well-trained participants, especially if they are engaged in resistance training.

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Section: Discussionmentioning

confidence: 97%

Post-exercise Endothelium-Dependent Vasodilation Is Dependent on Training Status

et al. 2020

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“…However, no study examined whether a single bout of resistance exercise affects blood Klotho concentration. Conversely, a hypertensive stimulus induced by a single bout of resistance exercise acutely induced endothelial dysfunction (Morishima et al, 2018, Morishima, Iemitsu, et al, 2019Morishima, Toyoda, et al, 2019;Morishima et al, 2020). Given that Klotho is thought to positively affect endothelial function (Keles et al, 2015), we hypothesized that the serum Klotho concentration would decrease All baseline and post measurements were collected in the supine position.…”

Section: Discussionmentioning

confidence: 99%

“…In the second visit, subjects were asked to eat a light meal at least 2 h prior to arriving to the laboratory. The method (i.e., a light meal before experiment) has been approved by many researchers in previous studies (Morishima et al 2018; Morishima, Iemitsu, et al, 2019; Morishima, Toyoda, et al, 2019; Restaino et al, 2015, 2016). In addition, subjects were prohibited to take caffeine and alcohol for at least 10 h. They were also not allowed to perform exercise for 24 h prior to the study visit.…”

Section: Methodsmentioning

confidence: 99%

“…Although some studies indicated inconsistent results (Jurva et al, 2006;Varady et al, 2010), we have reported that acute resistance exercise that induces temporal hypertension caused endothelial dysfunction (Morishima et al, 2018;Morishima, Iemitsu et al, 2019;Morishima, Toyoda et al, 2019, Morishima et al, 2020. Indeed, resistance exercise with a smaller increase in blood pressure does not lead to endothelial dysfunction (Morishima et al, 2018(Morishima et al, , 2020.…”

Section: Introductionmentioning

confidence: 90%

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Impact of a single bout of resistance exercise on serum Klotho in healthy young men

Morishima

Ochi

2021

Physiological Reports

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Background It has been shown that Klotho protects vascular endothelial function. Given that a single bout of resistance‐exercise‐induced hypertensive stimulus causes endothelial dysfunction, we postulated that acute resistance exercise would reduce serum Klotho levels. In this respect, the reduction in serum Klotho levels would be associated with the response of flow‐mediated dilation (FMD). Therefore, the purpose of this study was to investigate the impact of acute resistance exercise on the Klotho response in serum. In addition, we examined the relationship between the serum Klotho and FMD responses following acute resistance exercise. Methods Twelve untrained men participated in this study (20.4 ± 0.3 years). Following baseline measurements (blood pressure, blood collection, FMD), subjects performed leg extensions, which consisted of 10 repetitions for five sets at 70% of one‐repetition maximum. After the exercise, measurement of blood pressure, blood collection, and FMD assessment were repeated for 60 min. We analyzed Klotho and endothelin‐1 (ET‐1) concentrations in blood serum. Results As expected, the exercise significantly elevated blood pressure and led to decreased FMD (p < 0.05). However, Klotho concentrations were significantly increased following exercise (p < 0.05). No correlation was observed in Klotho and FMD responses following acute resistance exercise. However, there was a significant positive correlation between Klotho and ET‐1 in response to resistance exercise (p < 0.05). Conclusion In conclusion, the present study reveals that serum Klotho significantly increased following a single bout of resistance exercise. However, the increase in Klotho may not associate with the acute reduction in endothelial function.

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“…Some studies also tested the effect of combined aerobic and resistance exercise on endothelial function. In young healthy subjects, impaired endothelial function after the resistance exercise was restored with successive 10-min cycling [112], while 45-min cycling prior to resistance exercise did not prevent the acute impairment in endothelial function after resistance exercise [113]. The detrimental effects of resistance exercise on endothelial function in young healthy subjects was also prevented when resistance exercise was performed at high intensity but with low repetitions [114].…”

Section: Aerobic Versus Resistance Exercisementioning

confidence: 94%

Vascular Ageing and Aerobic Exercise

Kozàkovà

Palombo

2021

IJERPH

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Impairment of vascular function, in particular endothelial dysfunction and large elastic artery stiffening, represents a major link between ageing and cardiovascular risk. Clinical and experimental studies identified numerous mechanisms responsible for age-related decline of endothelial function and arterial compliance. Since most of these mechanisms are related to oxidative stress or low-grade inflammation, strategies that suppress oxidative stress and inflammation could be effective for preventing age-related changes in arterial function. Indeed, aerobic physical activity, which has been shown to improve intracellular redox balance and mitochondrial health and reduce levels of systemic inflammatory markers, also improves endothelial function and arterial distensibility and reduces risk of cardiovascular diseases. The present paper provides a brief overview of processes underlying age-related changes in arterial function, as well as the mechanisms through which aerobic exercise might prevent or interrupt these processes, and thus attenuate vascular ageing.

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Short‐term cycling restores endothelial dysfunction after resistance exercise

Cited by 14 publications

References 31 publications

Post-exercise Endothelium-Dependent Vasodilation Is Dependent on Training Status

Post-exercise Endothelium-Dependent Vasodilation Is Dependent on Training Status

Impact of a single bout of resistance exercise on serum Klotho in healthy young men

Vascular Ageing and Aerobic Exercise

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