Short‐term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects

Martina, V.; Benso, Andrea; Gigliardi, Valentina Ramella; Masha, Andi; Origlia, C.; Granata, Riccarda; Ghigo, Ezio

doi:10.1111/j.1365-2265.2006.02454.x

Cited by 18 publications

(7 citation statements)

References 47 publications

(84 reference statements)

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“…Several clinical and population-based studies suggest that DHEAS plays a protective role against atherosclerosis and coronary artery disease in men (42,43). One study found that chronic DHEA supplementation exerts anti-atherogenic effects although homocysteine concentrations were not modified by the treatment (44). It seems likely that the anti-atherogenic effects of DHEAS are independent of its action on plasma homocysteine concentrations.…”

Section: Discussionmentioning

confidence: 99%

Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men

et al. 2006

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Objective: To investigate whether circulating levels of testosterone (total, bioavailable), estradiol (total, bioavailable), and DHEA sulfate (DHEAS) are associated with fasting plasma homocysteine (tHcy) levels in middle-aged and elderly men. Design: A population-based sample of 400 independently living men between 40 and 80 years of age in a cross-sectional study. Methods: Total testosterone, sex hormone binding globulin (SHBG), and total estradiol were measured by RIA methods and bioavailable testosterone and estradiol were calculated. DHEAS was measured using an immunometric technique. Fasting homocysteine was measured by fluorescence polarization immunoassay. Anthropometric characteristics were also measured and two standardized questionnaires completed, including life-style factors and diet. Linear regression analysis adjusted for age, body mass index (BMI), creatinine clearance, and mean visceral fat was used to assess the association of endogenous sex hormones and fasting plasma homocysteine levels. Results: After adjustment for age, BMI, creatinine clearance, and mean visceral fat no statistically significant association was observed between testosterone (total, bioavailable), DHEAS, and estradiol (total, bioavailable)levels with natural log tHcy (bZK2!10 K3

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Section: Discussionmentioning

confidence: 99%

Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men

et al. 2006

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“…cGMP, which serves the role of acetylcholine, is widely distributed in various tissues. Previous studies (25,26) demonstrated that the cGMP is positively correlated to DHEAS. The present study additionally demonstrated that the cGMP level in the PCOS subgroup 1 was elevated compared with the control group.…”

Section: Discussionmentioning

confidence: 84%

UPLC/Q‑TOF‑MS based plasma metabolomics and clinical characteristics of polycystic ovarian syndrome

et al. 2018

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The present study aimed to develop novel diagnostic methods for polycystic ovarian syndrome (PCOS) by screening and identifying specific PCOS-associated metabolic markers using plasma metabolomics. Ultra-performance liquid chromatography/quadrapole-time of flight-mass spectrometry was adopted to establish the plasma metabolic fingerprint of 49 patients and 50 normal controls, in order to screen the potential metabolic markers. In addition, these markers were integrated with the clinical indexes, followed by focused analysis to obtain diagnostic markers. The present results demonstrated that not only was the concentration of palmitoyl sphingomyelin in plasma of patients with PCOS significantly increased; however, a statistically significant difference between the two PCOS subgroups was additionally demonstrated. At the same time, the concentrations of cyclic guanosine monophosphate (cGMP) and dehydroepiandrosterone sulphate in the plasma of patients of the subgroup 1 were significantly elevated. These markers were additionally integrated with the clinical index number of follicles in the left ovary and high-density lipoprotein (HDL-C), followed by receiver operating characteristic curve analysis, which demonstrated a diagnostic accuracy of ~90% in the control and the two subgroups. The integrated marker system consisting of palmitoyl sphingomyelin, cGMP and androsterone sulfate, as well as the number of left follicles and HDL-C may be used for the accurate diagnosis and classification of PCOS. These results confirmed that the abnormalities in hormone metabolism and lipid metabolism disorder were primarily involved in the onset of PCOS.

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“…In elderly subjects, physiological doses (50 mg p.o. daily) and long-term administration (for 2 months) of DHEA induced an increase in platelet cGMP levels, as a marker of nitric oxide production, which may suggest a possible antiatherogenic effect of this steroid in physiological concentrations [187].…”

Section: Studies Using Ex Vivo Platelet Function Assaymentioning

confidence: 94%

Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review

Roşca

Vlădăreanu

Mititelu

et al. 2021

JCM

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Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential.

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Short‐term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects

Cited by 18 publications

References 47 publications

Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men

Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men

UPLC/Q‑TOF‑MS based plasma metabolomics and clinical characteristics of polycystic ovarian syndrome

Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review

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