Short-Term Dietary Intake of C18:1 Trans Fatty Acids Decreases the Function of Cellular Immunity in Healthy Young Men

Dlouhý, Pavel; Kučera, Petr; Kraml, Pavel; Pompachova, Alexandra; Potočková, Jana; Smejkalova, V.; Mokrejš, Pavel; Jaček, Martin; Andĕl, M

doi:10.1159/000162679

Cited by 7 publications

(3 citation statements)

References 77 publications

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“…A diet rich in various trans -C18:1 has been shown to increase the serum levels of all TFA to between 40–120 mM [29], suggesting that the in vitro study TFA doses maybe 2–4 times higher than found in human serum. In vitro studies are limited in that higher concentrations are necessary in order to observe a biologic effect and need to be confirmed in dietary studies.…”

Section: Discussionmentioning

confidence: 95%

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

et al. 2011

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Intake of trans fatty acids (TFA), which are consumed by eating foods made from partially hydrogenated vegetable oils, is associated with a higher risk of cardiovascular disease. This relation can be explained by many factors including TFA's negative effect on endothelial function and reduced nitric oxide (NO) bioavailability. In this study we investigated the effects of three different TFA (2 common isomers of C18 found in partially hydrogenated vegetable oil and a C18 isomer found from ruminant-derived—dairy products and meat) on endothelial NF-κB activation and nitric oxide (NO) production. Human endothelial cells were treated with increasing concentrations of Elaidic (trans-C18:1 (9 trans)), Linoelaidic (trans-C18:2 (9 trans, 12 trans)), and Transvaccenic (trans-C18:1 (11 trans)) for 3 h. Both Elaidic and Linoelaidic acids were associated with increasing NF-κB activation as measured by IL-6 levels and phosphorylation of IκBα, and impairment of endothelial insulin signaling and NO production, whereas Transvaccenic acid was not associated with these responses. We also measured superoxide production, which has been hypothesized to be necessary in fatty acid-dependent activation of NF-κB. Both Elaidic acid and Linoelaidic acid are associated with increased superoxide production, whereas Transvaccenic acid (which did not induce inflammatory responses) did not increase superoxide production. We observed differential activation of endothelial superoxide production, NF-κB activation, and reduction in NO production by different C18 isomers suggesting that the location and number of trans double bonds effect endothelial NF-κB activation.

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Section: Discussionmentioning

confidence: 95%

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

et al. 2011

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“…LA and EA are known to be risk factors for CRCs (14,22–24), enhancing inflammation and suppressing mucosal immunity (25–28). LA-derived prostaglandin E2, produced by cyclooxygenase-2, induces chronic persistent inflammation, which produces reactive oxygen species (25,26).…”

Section: Discussionmentioning

confidence: 99%

“…LA-derived prostaglandin E2, produced by cyclooxygenase-2, induces chronic persistent inflammation, which produces reactive oxygen species (25,26). Likewise, EA induces secretion of TNF-α, activation of nuclear factor-κB, and inhibition of cluster of differentiation 8+ T-lymphocytes (27,28). …”

Section: Discussionmentioning

confidence: 99%

Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines

et al. 2017

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The present study investigated the effects of two major dietary fatty acid components, linoleic acid (LA) and elaidic acid (EA), on the antitumor effects of 5-fluorouracil (5-FU) in the LL2, CT26 and CMT93 mouse cancer cell lines. Concurrent treatment with LA and 5-FU elicited a decreased cell viability compared with treatment with 5-FU alone. In addition, increased inhibition of growth was observed following concurrent treatment with EA and 5-FU. Sequential treatment of LA followed by 5-FU abrogated the anticancer effects of 5-FU, and treatment with EA followed by 5-FU increased cancer cell growth in addition to abrogating the anticancer effects of 5-FU. The expression of the stem cell markers CD133 and nucleostemin (NS) increased in all three cell lines treated concurrently with 5-FU and either LA or EA when compared with cells treated with 5-FU alone. Aldehyde dehydrogenase activity in the cancer stem cells (CSCs), in response to concurrent treatment with 5-FU and either LA or EA, was increased compared with 5-FU treatment alone. 5-FU inhibited the growth of CT26 tumors, but co-treatment with either LA or EA abrogated this effect. NS-positive CSCs were more abundant in CT26 tumors treated with 5-FU and either LA or EA compared with those treated with 5-FU alone. The results of the present study suggested that, rather than altering the sensitivity of cancer cells to 5-FU, LA and EA may promote the survival of CSCs. The results indicated that dietary composition during chemotherapy is an important issue.

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Trans-fatty acids and nonlipid risk factors

Wallace¹,

Mozaffarian

2009

Curr Atheroscler Rep

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Consumption of industrially produced trans-fatty acids (TFA) is associated with substantial risk of coronary heart disease (CHD). The magnitude of this relationship, as well as emerging associations with end points such as diabetes and sudden cardiac death, cannot be fully explained by the well-established adverse effects of TFA on serum lipids. We review the evidence for effects of TFA intake on nonlipid risk factors. Based on evidence from randomized controlled trials, observational studies, animal experiments, and in vitro studies, these include effects on systemic inflammation, endothelial dysfunction, visceral adiposity, insulin resistance, and arrhythmic risk. The types and strength of evidence for each of these nonlipid effects varies, but the overall constellation of findings is qualitatively and quantitatively unique among dietary fats. The multiple adverse effects and implicated pathways are consistent with the observed strong associations of TFA consumption with CHD risk. These nonlipid effects also explain why TFA consumption may adversely impact other non-CHD diseases and end points.

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Short-Term Dietary Intake of C18:1 Trans Fatty Acids Decreases the Function of Cellular Immunity in Healthy Young Men

Cited by 7 publications

References 77 publications

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines

Trans-fatty acids and nonlipid risk factors

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