Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men

Abstract

Objective: To determine the tolerance of increasing dosages of an incompletely hydrolysed and/or incompletely absorbed food dextrin coming from wheat starch, NUTRIOSE s FB, at daily levels of 10 and 15 g up to 60 and 80 g, respectively. Design: A randomized, double-blind, multiple dose, placebo-controlled, combined crossover and parallel trial.

Evaluation of the Effect of Four Fibers on Laxation, Gastrointestinal Tolerance and Serum Markers in Healthy Humans

“…The effect of RS on fecal output has been mixed and may depend on the physicochemical properties of the specific RSs. High doses of wheat dextrin (up to 80 g/day) had only a minimal effect on fecal output [13] , while another study with lower doses of RS2 and RS3 (30 g/day) showed that both altered fecal weight in healthy humans [14] . Retrograded maltodextrin (40-60 g/day) administered for 21 days produced an increase in total bowel movements and frequency of watery feces [15] .…”

Macronutrients and type 1 diabetes (revision number 6)

“…Most trials administer either fructo-oligosaccharides or inulin, compared with a maltodextrin control; seven trials administer doses between 10-18g/day (Pedersen et al, 1997;Davidson et al, 1998;Letexier et al, 2003;Cani et al, 2006;Forcheron & Beylot, 2007;Genta et al, 2009;Cani et al, 2009), two trials administer doses of 20-21g/day (Luo et al, 1996;Parnell & Reimer, 2009). Two trials administer a modified dextrin in a dose-response manner at doses of 30, 40, 60 or 80 g/day (Van den Heuvel et al, 2004;Pasman et al, 2006) 9.11. No significant effect of non-digestible oligosaccharide or inulin supplementation and energy intake is demonstrated (-378kJ, 95% CI -791, 36kJ; p=0.07).…”

“…Eleven randomised controlled trials in adults were identified that presented evidence on non-digestible oligosaccharide or inulin supplementation and energy intake, eight of which were included in a meta-analysis (Luo et al, 1996;Pedersen et al, 1997;Davidson et al, 1998;Cani et al, 2006;Pasman et al, 2006;Forcheron & Beylot, 2007;Cani et al, 2009;Parnell & Reimer, 2009). Three trials could not be included in a meta-analysis as they did not report the necessary data (Letexier et al, 2003;Van den Heuvel et al, 2004;Genta et al, 2009)(Cardio-metabolic review, Energy Intake and Eating Motivation review, p115-118).…”

Resistant Dextrins as Prebiotic

“…Very well tolerated, Nutriose may be 20-25% of a product's composition without causing discomfort or bloating. About 15% of Nutriose are absorbed in the small intestine, about 75% fermented in the large intestine, while the remainder (about 10%) is excreted in the faeces [72,110]. Nutriose induced an increase of the colonic saccharolytic flora and decrease in potentially harmful Clostridium perfringens in human faeces [54,72].…”

“…Nutriose induced an increase of the colonic saccharolytic flora and decrease in potentially harmful Clostridium perfringens in human faeces [54,72]. Nutriose induced a decrease in the faecal pH of human volunteers, increased production of short chain fatty acids (SCFAs) in rats [54], induced changes in faecal bacterial enzyme concentration [72,110]. It was also shown that learning (respectively physical) performances are improved in rats 180 minutes (respectively 150 minutes) after the consumption of Nutriose, compared to dextrose.…”