Short-term dynamic changes in neutralizing antibodies against enterovirus 71 after vaccination

Wang, S Y; Ji, Zeng; Zhang, Xinpei; Gan, Zhengkai; Fan, Jianqiang; Chen, Ying-ping; Liang, Zhenzhen; Hu, Xiaosong; Zeng, Gang; Lv, Huakun

doi:10.1080/21645515.2020.1711678

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…It was suggested that pre-immunization blocks EV71 infection, which is due to the previous effect of IgM produced by EV71 vaccine-induced mice ( 37 ). As indicated from recent clinical trials of the EV71 vaccine, it can be used for emergency vaccination for anti-EV71 infection ( 38 ). At present, the CVA6 vaccine has not been used clinically, so it is necessary to clarify the type of antibodies induced by the CVA6 vaccine and the level of neutralizing antibodies and its changes, for the early prevention of CVA6 infection.…”

Section: Discussionmentioning

confidence: 99%

A 10-Day-Old Murine Model of Coxsackievirus A6 Infection for the Evaluation of Vaccines and Antiviral Drugs

Jiang¹,

Zhang

Lin³

et al. 2021

Front. Immunol.

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Coxsackievirus A6 (CVA6) is recognized as a major enterovirus type that can cause severe hand, foot, and mouth disease and spread widely among children. Vaccines and antiviral drugs may be developed more effectively based on a stable and easy-to-operate CVA6 mouse infection model. In this study, a wild CVA6-W strain was sub-cultured in newborn mice of different ages (in days), for adaptation. Therefore, a CVA6-A mouse-adapted strain capable of stably infecting the mice was generated, and a fatal model was built. As the result indicated, CVA6-A could infect the 10-day-old mice to generate higher levels of IFN-γ, IL-6, and IL-10. The mice infected with CVA6-A were treated with IFN-α1b at a higher dose, with complete protection. Based on this strain, an animal model with active immunization was built to evaluate antiviral protection by active immunization. The three-day-old mice were pre-immunized with inactivated CVA6 thereby generating IgM and IgG antibodies within 7 days that enabled complete protection of the pre-immunized mice following the CVA6 virus challenge. There were eight mutations in the genome of CVA6-A than in that of CVA6-W, possibly attributed to the virulence of CVA6 in mice. Briefly, the CVA6 infection model of the 10-day-old mice built herein, may serve as an applicable preclinical evaluation model for CVA6 antiviral drugs and vaccine study.

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Section: Discussionmentioning

confidence: 99%

A 10-Day-Old Murine Model of Coxsackievirus A6 Infection for the Evaluation of Vaccines and Antiviral Drugs

Jiang¹,

Zhang

Lin³

et al. 2021

Front. Immunol.

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“…Indeed, EV71 is the main virus strain causing HFMD in infants. 3 Therefore, it is highly infectious and can infect the central nervous system, posing a serious threat to public health. 4 At present, the main drugs used in clinical drug treatments, such as ribavirin and oseltamivir, have limited therapeutic effects and toxic side effects 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…It can combine with appropriate compounds to stabilize the viral capsid and prevent the un‐coating of virus and release of RNA. Indeed, EV71 is the main virus strain causing HFMD in infants 3 . Therefore, it is highly infectious and can infect the central nervous system, posing a serious threat to public health 4 .…”

Section: Introductionmentioning

confidence: 99%

Isolation and identification of active components from Grifola frondosa and its anti‐EV71 virus effect

Xiong,

Jiang,

et al. 2024

J Sci Food Agric

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BACKGROUNDIt is reported that anti‐enterovirus 71 (EV71) drugs have some side effects on human health. Notably, fungi plays a crucial role in promoting human health and anti‐virus. Grifola frondosa is a type of large medicinal and edible fungi, rich in active substances. The present study aimed to investigate the anti‐EV71 effect of G. frondosa and the potential active substances.RESULTSIn the present study, the water extract of G. frondosa was subjected to ethanol precipitation to obtain the water‐extracted supernatant of G. frondosa (GFWS) and water‐extracted precipitation of G. frondosa. Their inhibitory effects on EV71 virus were studied based on a cell model. The results showed that GFWS had stronger security and anti‐EV71 effects. In addition, the chemical constituents of GFWS were identified by ultra‐high performance liquid chromatography‐tandem mass spectrometry, which were selected for further separation and purification. Three compounds, N‐butylaniline, succinic acid and l‐tryptophan, were isolated from GFWS by NMR spectroscopy. It is noteworthy that N‐butylaniline and l‐tryptophan were isolated and identified from the G. frondosa fruiting bodies for the first time. Our study found that l‐tryptophan has anti‐EV71 virus activity, which reduced EV71‐induced apoptosis and significantly inhibited the replication process after virus adsorption. Furthermore, it could also bind to capsid protein VP1 to prevent the virus from attaching to the cells.CONCLUSIONl‐tryptophan was an inhibitor of the EV71 virus, which could be used in infant nutrition and possibly provide a new drug to treat hand, foot and mouth disease. © 2024 Society of Chemical Industry.

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Analysis of the Impact of Inactivated A71 Vaccine on the Incidence of Hand–Foot–Mouth Disease in Pudong New Area, Shanghai

Yang,

Liu,

Wang

et al. 2024

Vaccines

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The aim of this study was to investigate the level of inactivated A71 (EV-A71) vaccination in Pudong New Area of Shanghai and its effects on the epidemiology and pathogen spectrum of hand–foot–mouth disease (HFMD) in this area, as well as to provide a basis for improving the prevention and control strategy of HFMD in this area. Data were collected from the “Comprehensive Management Cloud Platform for Immunization Program” system from December 2016 to December 2022. The data on HFMD cases from January 2012 to December 2022 were extracted from the “China Information System for Disease Control and Prevention”. A total of 484,056 doses were administered. The vaccination rate of the first dose was 14.03%, and the full vaccination rate was 13.33%. There were significant differences between the first dose and the full vaccination rate in different years (χ2 = 46,538.831, p < 0.001, χ2 = 50,013.946, p < 0.001). A total of 91625 cases of HFMD were reported, including 58 severe cases, and no deaths. Before and after the administration of the inactivated EV-A71 vaccine, there were statistical differences in the distribution of HFMD cases in terms of gender, household registration, occupation, and age (p < 0.001). The etiological surveillance results showed that the rate of enterovirus positivity was 84.15%, with 9.85% being EV-A71, 23.74% CV-A16, and 50.56% non-EV-A71 and non-CV-A16. The coverage rate of the inactivated EV-A71 vaccine in Pudong New Area was not high, and the incidence of HFMD showed a downward trend after the postmarketing of the vaccine. The majority of HFMD infections were non-EV-A71 and non-CV-A16, with CV-A6 accounting for the highest proportion. It is recommended to accelerate the development of combined vaccines to provide more antibody protection.

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Short-term dynamic changes in neutralizing antibodies against enterovirus 71 after vaccination

Cited by 3 publications

References 18 publications

A 10-Day-Old Murine Model of Coxsackievirus A6 Infection for the Evaluation of Vaccines and Antiviral Drugs

A 10-Day-Old Murine Model of Coxsackievirus A6 Infection for the Evaluation of Vaccines and Antiviral Drugs

Isolation and identification of active components from Grifola frondosa and its anti‐EV71 virus effect

Analysis of the Impact of Inactivated A71 Vaccine on the Incidence of Hand–Foot–Mouth Disease in Pudong New Area, Shanghai

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