Short-term effect of a new mouthrinse formulation on oral malodour after single use in vivo : a comparative, randomized, single-blind, parallel-group clinical study

Abstract

This study aimed to compare a new chlorhexidine (CHX)-free mouthrinse containing amine fluoride/stannous fluoride (ASF) against a benchmark containing CHX with respect to their effect on oral malodour after single use. A total of 42 male and female subjects with an intraoral cause of bad breath, each with an organoleptic rating (OR) of at least 2 and a total volatile sulfur compound (VSC) concentration higher than 130 ppb, participated in the study. Subjects were allocated to one of three treatment groups (i.e. CHX-free ASF mouthrinse, CHX benchmark mouthrinse or water) according to a randomization list. Participants received written instructions on precautions to be taken for optimal breath analysis. Eight trained and qualified odour judges assessed the subjects' malodour by OR at baseline and 30 min and 4 h after single use of the mouthrinses. Additionally, VSC levels were measured at baseline and 4 h after using the mouthrinse. Treatment with water alone led already to some reduction in OR with mean differences to baseline of -1.13 at 30 min and -0.64, 4 h after treatment. Both CHX-free ASF product (-1.51) and CHX (-1.48) provided a significantly stronger OR reduction than water at 30 min (p < 0.05). Only CHX-free ASF treatment showed a sustained benefit in terms of significantly better OR reduction after 4 h (-1.17, p < 0.05), whereas CHX (-0.81) was not significantly different from water (-0.64, p = 0.517). Both ASF (-90.9%) and CHX (-81.6%) reduced VSC levels significantly stronger than water (-53.5%; p < 0.001). OR and VSC readings in the group using the CHX mouthrinse did not differ significantly from those in the group using the CHX-free ASF formulation. The newly developed CHX-free ASF mouthrinse significantly reduced oral malodour after single use, both in terms of OR and VSC levels. Efficacy was comparable to that of the CHX benchmark product.

Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial

“…The results of this study are in agreement with two recent papers evaluating the effect of a commercial formulation (meridol â HALITOSIS: AmF/SnF 2 , 0.2% of zinc lactate and oral malodour counter-actives). This new formulation significantly reduced, on short and long term, oral malodour in volunteers with morning bad breath (Wigger-Alberti et al 2009, Wilhelm et al 2010. meridol â with zinc lactate added was the only rinse with masking effect significantly different from the positive control.…”

Periodontal diseases as a source of halitosis: a review of the evidence and treatment approaches for dentists and dental hygienists

“…The combination of Zn++ and chlorhexidine seems to act synergistically . The addition of zinc ions to a basic formulation containing amine fluoride and stannous fluoride caused a short‐ and long‐term reduction of oral malodor indicators in volunteers with morning bad breath as well as in volunteers with obvious halitosis .…”

Effects of single rinse with three different types of mouthwashes on VSCs levels in morning breath: Randomized, double‐blind, crossover clinical trial

“…However, several studies in literature reported the effectiveness of chlorhexidine and amine fluoride/stannous fluoride (AmF/SnF 2 ) on plaque control based on their antimicrobial properties 35,36 . This formulation significantly reduced, on both short‐ and long‐term oral malodour in volunteers with morning bad breath 37,38 . The combination of these two molecules is also justified by their chemical interaction.…”

“…35,36 This formulation significantly reduced, on both short-and long-term oral malodour in volunteers with morning bad breath. 37,38 The combination of these two molecules is also justified by their chemical interaction. The stannous ions reduce the microbial glycolytic activity by oxidation of thiol groups in essential enzymes and delaying bacterial growth, while the combined action of the zinc chloride is able to convert H 2 S and CH 3 SH into non-volatile sulphides thus masking halitosis.…”