Short-term effect of malathion on rats' blood glucose and on glucose utilization by mammalian cells in vitro

Organophosphorus Insecticides and Glucose Homeostasis

“…High dose of diazinon has been reported to cause hyperglycemia in mice that follows a trend of normalization (Seifert, 2001). Acute exposure of rats to malathion resulted in hyperglycemia with peak increase occurring at 2.2h after administration followed by decrease after 4h (Rodrigues et al, 1986). A similar case of reversible hyperglycemia has been reported by Lasram et al, (2008) following administration of a single dose of malathion to rats.…”

“…This trend observed in the present study is consistent with other reports, which demonstrated reversible hyperglycemia in experimental animals following OPI administration. While Malathion has been reported to cause reversible hyperglycemia in rats (Gupta, 1974;Rodrigues et al, 1986;Seifert, 2001;Lasram et al, 2008), acute exposure to diazinon induced reversible hyperglycemia in mice (Seifert, 2001). Based on the above results, we reasoned that the reversible hyperglycemia could be triggered by transient changes in the hormonal milieu of glucose homeostasis.…”

Metabolic disorders of acute exposure to malathion in adult Wistar rats

“…The values remained appreciably high up to 6 h, and then began decreasing until reaching control levels. It is supported by many previous works a pronounced increase in blood glucose level which was going parallel to the inhibition of the ChE and the manifestation of cholinergic stimulation as a result of OPs intoxication [6,7,12,[24][25][26]. The mechanisms involved in the blood glucose alterations following OPs exposure are under investigation in the recent years.…”

Effect of subchronic exposure to malathion on glycogen phosphorylase and hexokinase activities in rat liver using native PAGE

“…Indeed, a kinetic study of the effect of malathion on the variation of glycemia proves that blood glucose concentration began decreasing 4 h after malathion administration and returned to control levels after 24 h (Rodrigues et al, 1986).…”

“…The blood glucose concentration increased just after the administration, began decreasing 4 h after and returned to control levels after 24 h (Rodrigues et al, 1986). However, other studies have demonstrated that malathion exposure induces hypoglycemia in chick (Arsenault et al, 1975).…”