Short-term effect of meteorological factors on the risk of rheumatoid arthritis hospital admissions: A distributed lag non-linear analysis in Hefei, China

Wang, Jinian; Yu, Lingxiang; Deng, Jixiang; Gao, Xing; Chen, Yuting; Shao, Ming; Zhang, Tao; Ni, Man; Pan, Faming

doi:10.1016/j.envres.2021.112168

Cited by 21 publications

(7 citation statements)

References 61 publications

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“…Some researches provided evidence indicating that high humidity increases the sensitivity of the body to mechanical stress and promotes the production of in ammatory cytokines in chondrocytes[28, 29], as well as altering metabolic products in arthritic mice [30]. Clinical studies have also con rmed the association between high humidity and arthritis pain, stiffness, and erythrocyte sedimentation rate levels [31,32]. In this study, relative humidity did not demonstrate a signi cant impact on patients with KOA.…”

Section: Discussionmentioning

confidence: 42%

Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study

shen,

Xu,

Jiang

et al. 2024

Preprint

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Background Osteoarthritis (OA) is a primary cause of disability among the elderly, and its pathogenesis is unclear. This study explores the correlations of different meteorological factors to characteristics and outcomes of knee osteoarthritis (KOA) patients through a 2-year follow-up. Methods The study enrolled 70 participants with KOA from Shanghai, China and conducted a follow-up assessment 2 years later. Assessment parameters included knee pain score, bone marrow abnormality (BMA) score, and levels of proinflammatory cytokine interleukin-1β (IL-1β) and IL-6. Additionally, meteorological data on temperature, wind speed, and relative humidity were collected from local meteorological stations. At baseline, meteorological factors were discretized into binary variables using their respective median values. The analysis of the associations between these meteorological factors and pain scores, BMA scores, and proinflammatory cytokines levels were conducted through the Mann-Whitney U test. Longitudinally, the associations between these meteorological factors and the mentioned KOA indicators were determined using multivariate linear regression models. Results At baseline, the average age of individuals is 60.6 years old. In the low temperature group individuals had higher WOMAC pain scores (p = 0.022), increased levels of IL-1β (p < 0.001) and IL-6 (p = 0.047) compared to those in the high temperature group. In longitudinal analysis, there were notable associations between temperature fluctuations and alterations in the pain scores (β=-0.916, p < 0.001), IL-1β (β=-0.859, p < 0.001) and IL-6 levels (β=-0.577, p = 0.006). Conclusion These findings provide evidence that temperature has a significant impact on the pain and inflammatory levels in patients with KOA. Conversely, wind speed and relative humidity do not exhibit such effects.

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Section: Discussionmentioning

confidence: 42%

Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study

shen,

Xu,

Jiang

et al. 2024

Preprint

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“…The independent variables were selected based on the literature review and a priori expert knowledge about the variables that were known to be associated with the time as well as on their availability in the dataset 9 17–19. Meteorological data (temperature, air pressure and rainfall) were collected from the China Meteorological Data Network (https://data.cma.cn/).…”

Section: Methodsmentioning

confidence: 99%

“…Rheumatoid arthritis (RA) is an autoimmune disease characterised by abnormal synovial hyperplasia and progressive destruction of cartilage and bone, affecting approximately 0.5%–1% of the adult population worldwide 1 2. Although the aetiology and pathogenesis of RA remain unclear, it is generally believed that multifactorial factors are involved, combining genetic predispositions3 4 and a variety of environmental factors, such as smoking, infection, microbiota, air pollution and climate factors 5–9…”

Section: Introductionmentioning

confidence: 99%

Geospatial analysis of the hospitalisation rate of patients with rheumatoid arthritis in Hunan: a cross-sectional Chinese study

Ge,

Wang,

Shi

et al. 2023

BMJ Open

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ObjectiveLittle is known about spatial variability of hospitalisation rate (HR) of patients with rheumatoid arthritis (RA) worldwide, especially in China.MethodsA cross-sectional study was conducted among patients with RA admitted to hospitals in Hunan Province. Global Moran’sIand local indicators of spatial association were used to explore the geospatial pattern of the HR of patients with RA. Generalised estimating equation analysis and geographically weighted regression were used to identify the potential influencing factors of the HR of patients with RA.ResultsThere were a total of 11 599 admissions, and the average HR was 1.57 per 10 000 population in Hunan. We detected different cluster patterns of the HR among patients with RA by local indicators of spatial association. Age, ethnicity, average temperature, average temperature range, average rainfall, regions, gross domestic product per capita, and doctors and hospitals per 10 000 people were risk factors for the HR. However, only average temperature, gross domestic product per capita and hospitals per 10 000 people showed different regression coefficients on the HR in different counties. The increase in hospitals increased the probability of HR from east to west in Hunan with a positive coefficient, while temperature decreases increased the risk of HR from south to north negatively. Similarly, the growth of gross domestic product per capita decreased the probability of HR from southwest to northeast.ConclusionA non-random spatial distribution of the HR of patients with RA was demonstrated in Hunan, and average temperature, gross domestic product per capita and hospitals per 10 000 people showed different regression coefficients on the HR in different counties. Our study indicated that spatial and geostatistics may be useful approaches for further study among patients with RA.

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“…Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by the erosion of adjacent cartilage and bone caused by chronic joint inflammation. Approximately 0.5-1% of adults in China suffer from RA, placing a heavy burden on economy and health [1]. Researches indicated that the main causes of RA are genetic and environmental factors [2,3].…”

Section: Introductionmentioning

confidence: 99%

SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis

et al. 2023

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Background Sirtuin 1 (SIRT1) is reported downregulated in rheumatoid arthritis (RA), and the protective effects of SIRT1 on tissue damage and organ failure may be related to cellular ferroptosis. However, the exact mechanism by which SIRT1 regulates RA remains unclear. Methods Quantitative real-time PCR (qPCR) and western blot assays were performed to explore the expressions of SIRT1 and Yin Yang 1 (YY1). CCK-8 assay was used for cytoactive detection. The interaction between SIRT1 and YY1 was validated by dual-luciferase reporter gene assay and chromatin immunoprecipitation (ChIP). DCFH-DA assay and iron assay were applied to detect the reactive oxygen species (ROS) and iron ion levels. Results In the serum of RA patients, SIRT1 was downregulated, but YY1 was upregulated. In LPS-induced synoviocytes, SIRT1 could increase cell viability and decrease ROS and iron levels. Mechanistically, YY1 downregulated the expression of SIRT1 by inhibiting its transcription. YY1 overexpression partly revised the effects of SIRT1 on ferroptosis in synoviocytes. Conclusion SIRT1 is transcriptionally repressed by YY1 and inhibits the ferroptosis of synoviocytes induced by LPS, so as to relieve the pathological process of RA. Therefore, SIRT1 might be a new diagnosis and therapeutic target of RA.

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Short-term effect of meteorological factors on the risk of rheumatoid arthritis hospital admissions: A distributed lag non-linear analysis in Hefei, China

Cited by 21 publications

References 61 publications

Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study

Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study

Geospatial analysis of the hospitalisation rate of patients with rheumatoid arthritis in Hunan: a cross-sectional Chinese study

SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis

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