Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

Caillaud, D.; Cheriaux, M.; Martin, S. Clark; Ségala, Claire; Dupuy, N.; Evrard, Bertrand; Thibaudon, M.

doi:10.1111/cea.13160

Cited by 11 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In temperate climates, peaks of fungal counts are observed in the summer, as in the case of Cladosporium spp. [31], or spore concentrations can also differ between days or years, as previously described for Alternaria spp. [32].…”

Section: Introductionmentioning

confidence: 81%

Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France

et al. 2020

View full text Add to dashboard Cite

The indoor microbial community is a mixture of microorganisms resulting from outdoor ecosystems that seed the built environment. However, the biogeography of the indoor microbial community is still inadequately studied. Dust from more than 3000 dwellings across France was analyzed by qPCR using 17 targets: 10 molds, 3 bacteria groups, and 4 mites. Thus, the first spatial description of the main indoor microbial allergens on the French territory, in relation with biogeographical factors influencing the distribution of microorganisms, was realized in this study. Ten microorganisms out of 17 exhibited increasing abundance profiles across the country: Five microorganisms (Dermatophagoïdes pteronyssinus, Dermatophagoïdes spp., Streptomyces spp., Cladosporium sphaerospermum, Epicoccum nigrum) from northeast to southwest, two (Cryptococcus spp., Alternaria alternata) from northwest to southeast, Mycobacteria from east to west, Aspergillus fumigatus from south to north, and Penicillium chrysogenum from south to northeast. These geographical patterns were partly linked to climate and land cover. Multivariate analysis showed that composition of communities seemed to depend on landscapes, with species related to closed and rather cold and humid landscapes (forests, located in the northeast) and others to more open, hot, and dry landscapes (herbaceous and coastal regions, located in the west). This study highlights the importance of geographical location and outdoor factors that shape communities. In order to study the effect of microorganisms on human health (allergic diseases in particular), it is important to identify biogeographic factors that structure microbial communities on large spatial scales and to quantify the exposure with quantitative tools, such as the multi-qPCR approach.

show abstract

Section: Introductionmentioning

confidence: 81%

Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This study was entirely anonymous and so approval from the French Ethics Committee was not required. Mould samples were collected daily from mid‐February to early October, as described previously [3 ]. Molds and pollens were sampled on the rooftop of a building of the University Hospital, with no nearby buildings obstructing air circulation.…”

Section: Methodsmentioning

confidence: 99%

Short-acting β2-agonists (SABA) bronchodilator sales and outdoor mould in central France

Caillaud¹,

Martin²,

Ségala³

et al. 2019

Clin Transl Allergy

Self Cite

View full text Add to dashboard Cite

BackgroundTemporal ecological studies have shown that outdoor moulds are associated with severe asthma exacerbations, as emergency department visits or hospitalisations. The aim of this was to assess the associations between daily sales of short-acting β2-agonists (SABA), a specific and frequent treatment for control of mild asthma exacerbations in children and young adults, and outdoor mould concentrations in the central France area over a 5 year period.MethodsThe relationship between daily changes in mould (25 species) concentrations and daily SABA sales within a population of patients aged 6 to 39 years in a middle-size town of central France (approximately 127,000) was obtained from social security database and analysed with generalized additive models, taking into account confounding factors (air pollution, weather conditions, pollen counts and trend).ResultsDaily SABA sales (mean, SD) rose from 17.3 (9.7) in 2010 to 22.7 (12) in 2015. The relative risk (RR [95% CI]) of SABA sales associated with an interquartile increase in mould concentration was significant in the whole population for Alternaria 1.06 [1.002–1.12]. When the influence of age and sex was accounted for, the relationship was significant only in 6–12 years old males for Alternaria 1.21 [1.04–1.41] and Aspergillus–Penicillium 1.08 [1.04–1.12].ConclusionsDaily SABA sales are positively associated with Alternaria spores in the general population of children and young adults. The association between daily SABA sales and temporal changes to Alternaria and Aspergillus–Penicillium in male children indicate that outdoor moulds contribute to asthma morbidity.

show abstract

“…Environmental exposure post‐pregnancy has also been surveyed in Clinical and Experimental Allergy. Caillaud et al report short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France. Quite unexpectedly, Brough et al found that higher levels of environmental exposure to peanut in the first few months of life appeared to increase the probability of developing school‐age peanut sensitization in atopic children.…”

Section: Epidemiologymentioning

confidence: 99%

Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II

Roberts

Almqvist

Boyle

et al. 2019

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

Cited by 11 publications

References 51 publications

Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France

Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France

Short-acting β2-agonists (SABA) bronchodilator sales and outdoor mould in central France

Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II

Contact Info

Product

Resources

About