Short‐term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study

Wilson, M.; Dekker, Jan Willem T.; Bruns, Emma R J; Borstlap, Wernard A. A.; Jeekel, J.; Zwaginga, Jaap Jan; Schipperus, Martin R.

doi:10.1111/trf.14456

Cited by 40 publications

(44 citation statements)

References 38 publications

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“…Fewer anaemic patients were found to require red cell transfusion after treatment with iron . Since then, more studies have been published supporting these conclusions . No clear differences in other outcomes have been found so far.…”

Section: Why?mentioning

confidence: 88%

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Optimisation of pre‐operative anaemia in patients before elective major surgery – why, who, when and how?

2019

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Anaemia in surgical patients is a common and serious problem; around 40% of patients presenting for major surgery are anaemic. Patients with pre-operative anaemia have significantly higher rates of morbidity and mortality and are likely to be transfused red cells. In addition, red cell transfusions are independently associated with worse outcomes. Pre-optimisation of anaemia in surgical patients leads to higher pre-operative haemoglobin concentrations and less need for transfusion. Patients undergoing major surgery (defined as blood loss > 500 ml expected or possible) should be optimised if their haemoglobin concentration is less than 130 g.l À1 on screening. Detection of anaemia should follow listing for surgery as soon as possible to allow enough time for optimisation. The most common cause of pre-operative anaemia is iron deficiency, which can be treated with iron therapy. Iron clinics should be set up in either primary or secondary care to allow for optimal treatment. In this review, we present literature supporting the optimisation of pre-operative anaemia and propose a treatment algorithm.

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Section: Why?mentioning

confidence: 88%

“…Several studies investigating the effect of treatment of pre‐operative anaemia have been published showing an increase in pre‐operative haemoglobin after i.v. iron treatment . To date, no studies have been published investigating treatment of pre‐operative anaemia on clinical outcomes in this group of patients.…”

Section: Who?mentioning

confidence: 99%

Optimisation of pre‐operative anaemia in patients before elective major surgery – why, who, when and how?

2019

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“…2 Numerous studies show the effectiveness of IV iron infusions in patients with anemia. 3,10 However, few studies examine the response to iron infusions in patients with advanced CKD before a major surgery. Our case demonstrates that IV iron and erythropoietin can successfully increase the Hg of a patient with severe anemia and advanced CKD before a major surgery with expected blood loss, and eliminate the need for allogeneic blood transfusions.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Intravenous Iron and Erythropoietin to Treat Severe Anemia in Patient With Stage 4 Kidney Disease Before Oncologic Surgery: A Case Report

2020

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Preoperative treatment of anemia with intravenous iron is inconsistent despite known risks of anemia and allogeneic blood transfusions. Limited research exists on the effectiveness of preoperative intravenous iron for chronic kidney disease (CKD) patients. We discuss a patient with severe anemia from advanced CKD, endometrial cancer, and menometrorrhagia. Her hemoglobin increased more than 2 g/dL after erythropoietin and two 750-mg ferric carboxymaltose infusions 5 weeks before a total abdominal hysterectomy and avoided blood transfusions perioperatively. By raising hemoglobin, preoperative intravenous iron and erythropoietin reduce blood transfusions and consequent risk of future allograft rejection and alloimmunization in potential transplant recipients.

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“…However, an analysis of previous studies investigating ingested iron as treatment of anemia identified it as potentially detrimental and hazardous for human colorectal cancer risk (87)(88)(89). Recent studies demonstrated that compared with oral iron, intravenous iron therapy is more effective in anemic patients with colorectal cancer with higher Tf and lower ferritin levels (90,91).…”

Section: Iron and Various Cancersmentioning

confidence: 99%

Iron metabolism and its contribution to cancer (Review)

et al. 2019

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Iron is an essential element for biological processes. Iron homeostasis is regulated through several mechanisms, from absorption by enterocytes to recycling by macrophages and storage in hepatocytes. Iron has dual properties, which may facilitate tumor growth or cell death. Cancer cells exhibit an increased dependence on iron compared with normal cells. Macrophages potentially deliver iron to cancer cells, resulting in tumor promotion. Mitochondria utilize cellular iron to synthesize cofactors, including heme and iron sulfur clusters. The latter is composed of essential enzymes involved in DNA synthesis and repair, oxidation-reduction reactions, and other cellular processes. However, highly increased iron concentrations result in cell death through membrane lipid peroxidation, termed ferroptosis. Ferroptosis, an emerging pathway for cancer treatment, is similar to pyroptosis, apoptosis and necroptosis. In the present review, previous studies on the physiology of iron metabolism and its role in cancer are summarized. Additionally, the significance of iron regulation, and the association between iron homeostasis and carcinogenic mechanisms are discussed. Contents 1. Introduction 2. Iron absorption 3. Iron distribution and excretion 4. Iron and various cancers 5. Mechanisms of iron-mediated proliferation of tumor cells 6. Ferroptosis: Iron-dependent cancer cell death 7. Conclusions

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Short‐term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study

Cited by 40 publications

References 38 publications

Optimisation of pre‐operative anaemia in patients before elective major surgery – why, who, when and how?

Optimisation of pre‐operative anaemia in patients before elective major surgery – why, who, when and how?

Preoperative Intravenous Iron and Erythropoietin to Treat Severe Anemia in Patient With Stage 4 Kidney Disease Before Oncologic Surgery: A Case Report

Iron metabolism and its contribution to cancer (Review)

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