Short-term effects of air pollutants on outpatients with psoriasis in a Chinese city with a subtropical monsoon climate

Wang, Ting; Xia, Yuan-Rui; Zhang, Xinhong; Qiao, Nini; Ke, Susu; Fang, Quan; Ye, Dong-Qing; Fan, Yunlong

doi:10.3389/fpubh.2022.1071263

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Among gas pollutants, NO 2 increased the risk of psoriasis occurrence. After inhalation, air pollutants can cause oxidative stress in the airway's epithelia but also reach peripheral tissues, such as skin, and due to oxidative stress-inflammation vicious circle, cause the production of proinflammatory cytokines that in turn are transferred into the bloodstream [30]. Also, direct skin contact with air pollutants can also add to the pathophysiology of psoriasis.…”

Section: Environmental Toxification and Psoriasis Diseasementioning

confidence: 99%

Psoriasis and exposome: Unveiling the inner and the external contributors of psoriasis disease

Zafiriou,

Karampinis,

Roussaki-Schulze

2024

Psoriasis - Recent Advances in Diagnosis and Treatment [Working Title]

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The term “exposome” encompasses all the environmental elements, both infectious and non-infectious, that an individual encounters throughout life. It refers to the collective exposure to various factors in the environment that can have an impact on human health and finally result in a disease or affect the disease course. The exposome is a term implicated in all skin diseases including psoriasis. Ranging from lifestyle habits such as diet, smoking, obesity, sunlight exposure, pre-existing diseases, and infectious agents’ exposure to patients’ unique features such as skin microbes, oxidative stress parameters, skin chemical environment, and cutaneous immune reactions, skin seems to encounter a variety of different exposures. All these exposures in turn affect and contribute in distinct ways to the pathogenesis pathways implicated in the creation of the psoriatic skin lesions and shape the disease course and progression. Also, the interaction between environmental and genetic factors is a well-established disease contributor. This chapter discusses the link between each aspect of exposome and psoriasis pathways and mechanisms as well as treatment plans taking into consideration environmental factors. Understanding the exposome–psoriasis relationship would lead to implications and targeted interventions to mitigate possible risk factors and give future directions.

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Section: Environmental Toxification and Psoriasis Diseasementioning

confidence: 99%

Psoriasis and exposome: Unveiling the inner and the external contributors of psoriasis disease

Zafiriou,

Karampinis,

Roussaki-Schulze

2024

Psoriasis - Recent Advances in Diagnosis and Treatment [Working Title]

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“…Psoriasis is a common inflammatory papulosquamous skin disorder, which is caused by the interplay of genetic, immunological, and environmental factors with a wide range of clinical manifestations (5,6). Psoriasis can occur at any age and is associated with several comorbidities, such as lymphoma and depression (7).…”

Section: Introductionmentioning

confidence: 99%

Genetically predicted ankylosing spondylitis is causally associated with psoriasis

et al. 2023

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BackgroundPrevious observational studies have reported the striking association between ankylosing spondylitis (AS) and psoriasis, but the causal relationship between the two diseases remains unclear.MethodsTwo-sample Mendelian randomization (MR) analysis with methods of inverse-variance weighted, MR-Egger regression, weighted median, and weighted mode was conducted to evaluate the bidirectional causal associations between AS and psoriasis. Effective single-nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS) were selected as instrumental variables (IVs). Sensitivity analyses were also applied to verify whether heterogeneity and pleiotropy can bias the results.ResultWe found positive causal effects of genetically increased AS risk on psoriasis (IVW: OR = 1.009, 95% CI = 1.005–1.012, p = 8.07E-07). Comparable outcomes were acquired by MR-Egger regression, weighted median, and weighted mode approaches. Nevertheless, we did not find significant causal effects of psoriasis on AS (IVW: OR = 1.183, 95% CI = 0.137–10.199, p = 0.879). The sensitivity analyses showed that the horizontal pleiotropy was unlikely to skew the causality. The leave-one-out analysis demonstrated that no single SNP can drive the MR estimates. No evidence of heterogeneity was found between the selected IVs.ConclusionOur findings provide evidence that AS has positive causal effects on the risk of psoriasis in the European population.

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Joint exposure to multiple air pollutants, genetic risk and incident psoriasis: a large-scale prospective cohort study

Xiong,

Xia,

Zhang

et al. 2024

British Journal of Dermatology

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Background Air pollution and genetic risk have been found to contribute to both onset and development of psoriasis. However, the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of incident psoriasis remains unknown. Objectives Our study aimed to assess the association between joint exposure to multiple air pollutants and the risk of psoriasis and the modification by the genetic susceptibility. Methods This prospective study included 451,064 participants with complete air pollution data and free of psoriasis at baseline from the UK Biobank. All participants were enrolled from 2006 to 2010 and followed up to 2022. The air pollution score (APS) was calculated to assess the joint exposure to multiple air pollutants, including particulate matter (PM) with diameters ≤ 2.5 μm (PM2.5), between 2.5 and 10 μm (PM2.5−10), and ≤ 10 μm (PM10), as well as nitrogen dioxide (NO2) and nitrogen oxides (NOx). To evaluate the genetic risk, the polygenic risk score (PRS) for psoriasis was constructed. The Cox proportional hazard models were used to assess the association of air pollution and genetic susceptibility with the risk of psoriasis. Stratified analyses were conducted based on the individual characteristics. Results During a median follow-up of 13.79 years, 4414 psoriasis events were recorded. The hazard ratios (HRs) [95% confidence intervals (CIs)] for psoriasis were 1.036 (0.936-1.147), 1.091 (0.987-1.206), 1.159 (1.048-1.283), and 1.163 (1.052-1.286) in higher quintile groups compared with the lowest quintile of APS (P trend <0.05). When considering genetic susceptibility, participants with high PRS and high APS had the greatest risk of incident psoriasis [HR (95% CI): 1.962 (1.630-2.362)] than those with low PRS and low APS. The HRs (95% CIs) for PM2.5-10, NOx, PM2.5 absorbance, PM2.5, NO2, and PM10 in the group with high exposure level and genetic risk were 1.831 (1.537-2.181), 1.722 (1.431-2.073), 1.698 (1.416-2.037), 1.619 (1.353-1.938), 1.504 (1.252-1.806), and 1.425 (1.192-1.704), respectively. Conclusions Long-term exposure to various air pollutants is positively associated with an increased risk of incident psoriasis, particularly in individuals with high genetic risk. More comprehensive measures are needed to reduce the air pollution levels for better prevention of psoriasis.

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Short-term effects of air pollutants on outpatients with psoriasis in a Chinese city with a subtropical monsoon climate

Cited by 4 publications

References 34 publications

Psoriasis and exposome: Unveiling the inner and the external contributors of psoriasis disease

Psoriasis and exposome: Unveiling the inner and the external contributors of psoriasis disease

Genetically predicted ankylosing spondylitis is causally associated with psoriasis

Joint exposure to multiple air pollutants, genetic risk and incident psoriasis: a large-scale prospective cohort study

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