Short-Term Effects of Ambient Air Pollution on ST-Elevation Myocardial Infarction Events: Are There Potentially Susceptible Groups?

Abstract

Background: Air pollution exposure is associated with greater risk for cardiovascular events. This study aims to examine the effects of increased exposure to short-term air pollutants on ST-segment elevation myocardial infarction (STEMI) and determine the susceptible groups. Methods: Data on particulate matter PM2.5 and PM10 and other air pollutants, measured at each of the 11 air-quality monitoring stations in Kaohsiung City, were collected between 2011 and 2016. The medical records of non-trauma adult (>17 years) patients who had visited the emergency department (ED) with a typical electrocardiogram change of STEMI were extracted. A time-stratified and case-crossover study design was used to examine the relationship between air pollutants and daily ED visits for STEMI. Results: An interquartile range increment in PM2.5 on lag 0 was associated with an increment of 25.5% (95% confidence interval, 2.6%–53.4%) in the risk of STEMI ED visits. Men and persons with ≥3 risk factors (male sex, age, hypertension, diabetes, current smoker, dyslipidemia, history of myocardial infarction, and high body mass index) for myocardial infarction (MI) were more sensitive to the hazardous effects of PM2.5 (interaction: p = 0.039 and p = 0.018, respectively). The associations between PM10, NO2, and O3 and STEMI did not achieve statistical significance. Conclusion: PM2.5 may play an important role in STEMI events on the day of exposure in Kaohsiung. Men and persons with ≥3 risk factors of MI are more susceptible to the adverse effects of PM2.5 on STEMI.

Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

“…28 Epidemiological studies have shown that participants with hyperlipidemia exposure to PM 2.5 may make them more susceptible to a higher risk of developing CVDs. [29][30][31] Therefore, we need a more thorough understanding of the potential mechanisms in order to develop preventive intervention strategies. Consequently, we use an ApoE −/− mouse model which is a mature animal model of hyperlipidemia.…”

The relationship between increased air pollution expressed as PM10 concentration and the frequency of percutaneous coronary interventions in patients with acute coronary syndromes—a seasonal differences

“…In the current study, we evaluated the short-term effects of PM 10 pollution on the frequency of ACSs treated with PCI. In a Boston study and other studies, a relationship was found between the short-term increase in air pollution (hours) and the increased incidence of ACS rate (Peters et al 2001, Pan et al 2019and Chen et al 2020. The relationship of the extent of air pollution expressed as PM 10 concentration has also been demonstrated in other countries with a warmer climate (Cendon et al 2006).…”

Fine Particulate Matter Constituents Associated With Emergency Room Visits for Pediatric Asthma: A Time-Stratified Case–Crossover Study in an Urban Area

“…2b). PM exposure increases the risk for cardiovascular events [5,6] and respiratory disease [3,4,12,14]. Children are highly vulnerable to the adverse effects of air pollution, particularly to respiratory diseases [12].…”