Short-term effects of cervical manipulation on edge light pupil cycle time: A pilot study

Gibbons, Peter; Gosling, Cameron; Holmes, Mathew

doi:10.1067/mmt.2000.108820

Cited by 27 publications

(39 citation statements)

References 8 publications

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“…14,47,90,91 In order to obtain an impression about the autonomic system, the pupil diameter and its response to stimuli can be measured. 49,52,54,56,69,70 A method of automated pupillometry was used in this study to capture pupil responsiveness. Pupillometry has been previously used to measure the pupil and has been shown to be an easy, valid, and reliable method of assessing the nervous system without the presence of much examiner bias.…”

Section: Discussionmentioning

confidence: 99%

“…49,52,54,56,69,70 Fully automated pupillometry devices have been used previously in a number of studies investigating autonomic nervous system activity. 53,56,[71][72][73][74][75][76] The human eye has difficulties detecting differences of the pupil that are smaller than 1.0 mm.…”

Section: Automated Measuresmentioning

confidence: 99%

“…Both the sympathetic and parasympathetic components influence the pupil. 43,[47][48][49] The innervation of the constrictor pupillae muscle is parasympathetic 50 and the dilator pupillae muscle is sympathetically innervated. 49 Based on a negative feedback mechanism within the autonomic nervous system, the pupil diameter is based on the functional balance between the sympathetic and parasympathetic nervous system.…”

mentioning

confidence: 99%

“…43,[47][48][49] The innervation of the constrictor pupillae muscle is parasympathetic 50 and the dilator pupillae muscle is sympathetically innervated. 49 Based on a negative feedback mechanism within the autonomic nervous system, the pupil diameter is based on the functional balance between the sympathetic and parasympathetic nervous system. 43,47,51 Pfeifer et al 52 demonstrated that pupil size increased by stimulation of the sympathetic nervous system and decreased during stimulation of the parasympathetic system.…”

mentioning

confidence: 99%

“…[53][54][55][56] A dilation of the pupil is a result of simultaneous increasing activity of the sympathetic system and decreasing parasympathetic activity. 45,47,49 There is a lack in the literature accounting for some of the neurophysiological effects that seem to take place following manipulation techniques. 11 Vicenzino et al demonstrated that a manipulation of the cervical spine resulted in an increase in pain threshold in the forearm and a sympathoexcitatory effect.…”

mentioning

confidence: 99%

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Immediate effects of a thoracic spine thrust manipulation on the autonomic nervous system: a randomized clinical trial

Sillevis¹,

Cleland²,

Hellman³

et al. 2010

Journal of Manual & Manipulative Therapy

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Thoracic spine manipulation has been shown to be effective for the management of neck pain. The purpose of this study was to investigate the immediate effect of a T3-T4 spinal thrust manipulation on autonomic nervous system activity in subjects with chronic cervical pain. An additional aim was to determine if the manipulation resulted in an immediate pain relief in patients with chronic neck pain when compared to a placebo intervention. One hundred subjects with chronic neck pain were randomly assigned to receive either a thoracic thrust manipulation or a placebo intervention. The Friedman's test was used to evaluate the change in pupil diameter within both groups. The Wilcoxen signed-ranks test was used to explore pupil changes over time and to make paired comparisons of the pupil change between the groups. The MannWhitney U test was used to compare the change in pain perception for the chronic cervical pain group subjects receiving either the thrust manipulation or the placebo intervention. The results demonstrated that manipulation did not result in a change in sympathetic activity. Additionally, there was no significant difference in the subject's pain perception (P50.961) when comparing the effects of the thrust manipulation to the placebo intervention within this group of subjects with chronic neck pain. The clinical impression of this study is that manipulation of the thoracic spine may not be effective in immediately reducing pain in patients with chronic neck pain.

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