Short-term effects of soy protein diet in patients with proteinuric glomerulopathies

Ahmed, Marion Souza; Calabria, Alessandra C.; Kirsztajn, Gianna Mastroianni

doi:10.1590/s0101-28002011000200006

Cited by 14 publications

(15 citation statements)

References 31 publications

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“…Our search identified 3917 reports, of which 3689 were excluded on the basis of review of titles and abstracts. The remaining 228 articles were reviewed in full, of which 104 provided data for 112 trial comparisons for inclusion in our analyses …”

Section: Resultsmentioning

confidence: 99%

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Mejía

Lytvyn

et al. 2017

JAHA

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BackgroundThere is a heightened interest in plant‐based diets for cardiovascular disease prevention. Although plant protein is thought to mediate such prevention through modifying blood lipids, the effect of plant protein in specific substitution for animal protein on blood lipids remains unclear. To assess the effect of this substitution on established lipid targets for cardiovascular risk reduction, we conducted a systematic review and meta‐analysis of randomized controlled trials using the Grading of Recommendations Assessment, Development, and Evaluation system.Methods and Results MEDLINE, EMBASE, and the Cochrane Registry were searched through September 9, 2017. We included randomized controlled trials of ≥3 weeks comparing the effect of plant protein in substitution for animal protein on low‐density lipoprotein cholesterol, non–high‐density lipoprotein cholesterol, and apolipoprotein B. Two independent reviewers extracted relevant data and assessed risk of bias. Data were pooled by the generic inverse variance method and expressed as mean differences with 95% confidence intervals. Heterogeneity was assessed (Cochran Q statistic) and quantified (I2 statistic). The overall quality (certainty) of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system. One‐hundred twelve randomized controlled trials met the eligibility criteria. Plant protein in substitution for animal protein decreased low‐density lipoprotein cholesterol by 0.16 mmol/L (95% confidence interval, −0.20 to −0.12 mmol/L; P<0.00001; I2=55%; moderate‐quality evidence), non–high‐density lipoprotein cholesterol by 0.18 mmol/L (95% confidence interval, −0.22 to −0.14 mmol/L; P<0.00001; I2=52%; moderate‐quality evidence), and apolipoprotein B by 0.05 g/L (95% confidence interval, −0.06 to −0.03 g/L; P<0.00001; I2=30%; moderate‐quality evidence).ConclusionsSubstitution of plant protein for animal protein decreases the established lipid targets low‐density lipoprotein cholesterol, non–high‐density lipoprotein cholesterol, and apolipoprotein B. More high‐quality randomized trials are needed to improve our estimates.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02037321.

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Section: Resultsmentioning

confidence: 99%

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Mejía

Lytvyn

et al. 2017

JAHA

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“…Soy is considered as a unique food that contains several nutrients, complex carbohydrates, vegetal protein, soluble and insoluble fibers, oligosaccharides, photochemistry, especially isoflavones, and minerals that it is not clear which compound is responsible for its effects. [ 26 45 ] Several mechanisms have suggested explaining soy effect. A component of soy that mentioned has a renoprotective effect is the isoflavones, which mechanisms are not clear.…”

Section: Discussionmentioning

confidence: 99%

“…The lower level of phosphorous and sodium in soy protein compared animal protein has been proposed as a mediator of the protecting effects of soy protein. [ 26 45 ] One possible mechanism that was suggested is the effect of soy protein on IGF-1. IGF-1 is the main regulator of renal remodeling and in animal studies revealed soy protein caused a reduction in circulating and renal IGF-1.…”

Section: Discussionmentioning

confidence: 99%

“…No beneficial effect was observed when using soy protein instead of animal protein. [ 26 ] It seems possible that these results are due to the baseline low levels of proteinuria, short-term use of soy protein and a low number of cases.…”

Section: Human Studymentioning

confidence: 99%

“…Some evidence has revealed that altering the quantity and the types of dietary protein exert the main effect on renal failure. [ 25 26 27 ] It is well-known that limiting dietary protein alleviate renal injury while high protein intake accelerates the development of CKD. [ 28 29 30 ] In recent times, protein quality by changing animal protein with plant protein, especially soy protein has been considered.…”

Section: Introductionmentioning

confidence: 99%

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Soy protein and chronic kidney disease: An updated review

et al. 2017

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Chronic kidney disease (CKD) is a serious universal problem that is the main risk for several diseases including cardiovascular disease. Dietary factors are important to prevent and control the kidney disease. Some evidence has shown that modifying the amount and the types of dietary protein exert a major effect on renal failure so limiting dietary protein and substituting animal protein with soy protein has suggested. However, there is a lot of controversy about it, especially in human. Thus, this paper will review the clinical trial studies conducted on the effects of soy protein intake on CKD in both animal and human and its effect mechanism.

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The effects of soy protein and soy isoflavones intake on chronic kidney disease: a systematic review and meta-analysis

Zhixiang,

Yongxing,

Juan

et al. 2024

Int Urol Nephrol

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Short-term effects of soy protein diet in patients with proteinuric glomerulopathies

Cited by 14 publications

References 31 publications

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Soy protein and chronic kidney disease: An updated review

The effects of soy protein and soy isoflavones intake on chronic kidney disease: a systematic review and meta-analysis

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