Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

Aslan, Serkan; Gül, Mehmet; Çakmak, Hüseyin Altuğ; Öztürk, Derya; Çelik, Ömer; Satılmışoğlu, Muhammet Hulusi; Göde, Safa; Taşbulak, Ömer; Yildirim, Aydın; Bakır, İhsan

doi:10.5603/cj.a2015.0024

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…Diastolic dysfunction, associated with impaired active relaxation, is a feature of most AS patients. Several studies showed improvement of diastolic function 6,7 including active relaxation early after AVR 8 , however, the percentage of patients with moderate to severe DD increases 10-years after AVR 9 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload

Miranda-Silva

Gonçalves-Rodrigues

Almeida-Coelho

et al. 2019

Sci Rep

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Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. However, recent evidence suggests that AVR outcome can be improved if performed earlier. After AVR, the process of left ventricle (LV) reverse remodelling (RR) is variable and frequently incomplete. In this study, we aimed at detecting mechanism underlying the process of LV RR regarding myocardial structural, functional and molecular changes before the onset of HF symptoms. Wistar-Han rats were subjected to 7-weeks of ascending aortic-banding followed by a 2-week period of debanding to resemble AS-induced LV remodelling and the early events of AVR-induced RR, respectively. This resulted in 3 groups: Sham (n = 10), Banding (Ba, n = 15) and Debanding (Deb, n = 10). Concentric hypertrophy and diastolic dysfunction (DD) were patent in the Ba group. Aortic-debanding induced RR, which promoted LV functional recovery, while cardiac structure did not normalise. Cardiac parameters of RV dysfunction, assessed by echocardiography and at the cardiomyocyte level prevailed altered after debanding. After debanding, these alterations were accompanied by persistent changes in pathways associated to myocardial hypertrophy, fibrosis and LV inflammation. Aortic banding induced pulmonary arterial wall thickness to increase and correlates negatively with effort intolerance and positively with E/e′ and left atrial area. We described dysregulated pathways in LV and RV remodelling and RR after AVR. Importantly we showed important RV-side effects of aortic constriction, highlighting the impact that LV-reverse remodelling has on both ventricles.

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Section: Introductionmentioning

confidence: 99%

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload

Miranda-Silva

Gonçalves-Rodrigues

Almeida-Coelho

et al. 2019

Sci Rep

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“…In addition, due to differences in clinical practice across centres, extrapolation of results may be of limited value. Evidence suggesting improved left atrial and left atrial appendage function after TAVR suggests that resolution of thrombus may be accelerated with anticoagulation [22]. Data regarding long-term follow-up with TOE to assess for resolution of LAT and SEC were not available, which is another limitation of the current study.…”

Section: Limitationsmentioning

confidence: 90%

Transcatheter aortic valve replacement in the setting of left atrial appendage thrombus†

Salemi

Micheli

Aftab

et al. 2018

Interactive CardioVascular and Thoracic Surgery

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“…LAA velocities improved significantly after TAVI in LFLG AS patients, but not in AS patients with other flow and gradient patterns. Recently, Serkan et al reported improvement in LAA velocities after TAVI especially in low EF and marked LV diastolic dysfunction. Our results were in line with their report.…”

Section: Discussionmentioning

confidence: 99%

Impact of transcatheter aortic valve implantation on left atrial appendage flow velocities

Ando

Holmes

Slovut

et al. 2016

J of Clinical Ultrasound

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Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

Abstract: (Cardiol J 2015; 22, 5: 527-534)

Cited by 5 publications

References 25 publications

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload

Transcatheter aortic valve replacement in the setting of left atrial appendage thrombus†

Impact of transcatheter aortic valve implantation on left atrial appendage flow velocities

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