Short-term Effects of Unilateral 1% Apraclonidine Therapy

Robin, Alan L.

doi:10.1001/archopht.1988.01060140058024

Cited by 96 publications

(34 citation statements)

References 14 publications

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“…These results are consistent with the known specificity of each ligand for adrenergic receptors [ 18], High density of receptors for U K -14,304 was found along the iris epithelium in the present experiments. These receptors would probably be located on the iris dilator muscles which run parallel to the iris epithelium, be cause alpha-2 adrenergic agonists are known to induce contraction of those muscles [1,2]. However, the present results cannot exclude a possibility that the iris epithelium itself has receptors for alpha-2 adrenergic agonists.…”

Section: Discussionmentioning

confidence: 43%

Localization of Alpha-2 Adrenergic Receptors in the Human Eye

Matsuo

Cynader

1992

Ophthalmic Res

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To elucidate sites of the action of alpha-2 adrenergic drugs, we localized binding sites for a potent alpha-2 adrenergic agonist, UK-14,304, in sections of the human cadaveric eye by an in vitro ligand-binding technique and autoradiography. Its specific binding sites were found in the iris epithelium and ciliary epithelium at a high level, and also in the ciliary muscle, retina, retinal pigment epithelium (and/or choroid). Binding of UK-14,304 to the ocular pigments was prevented by preincubating the eye sections with chloroquine, which reduced the non-specific binding to a low level.

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Section: Discussionmentioning

confidence: 43%

Localization of Alpha-2 Adrenergic Receptors in the Human Eye

Matsuo

Cynader

1992

Ophthalmic Res

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“…The use of brimonidine in children is contraindicated due to its systemic side effect and its use in adults is limited by its ocular side effects such as allergy (Rahman et al, 2010). The relatively specific α2 adrenergic agonist, apraclonidine, is reported to reduce both AH formation and outflow resistance (Gharagozloo et al, 1988;Robin, 1988). 2.…”

Section: Medical Treatment Of Glaucomamentioning

confidence: 39%

Mechanism of Aqueous Humor Secretion, Its Regulation and Relevance to Glaucoma

Shahidullah¹,

Almalki²,

Delamere³

2011

Glaucoma - Basic and Clinical Concepts

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“…This relatively se lective alpha-2-adrenergic agonist reduces intraocular pres sure (IOP) in normotensive volunteers and hypertensive pa tients [5][6][7][8]. In addition, it appears to reduce IOP further in patients treated with beta-blockers [9,10] as well as in pa tients taking maximally tolerated medications for various types o f glaucoma [11,12].…”

Section: Introductionsupporting

confidence: 46%

Short-Term Effect of Apraclonidine on Intraocular Pressure in Glaucoma Patients Receiving Timolol and Pilocarpine

et al. 1997

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A placebo-controlled, prospective study was undertaken to determine whether apraclonidine has an additive effect in eyes treated with timolol and pilocarpine. Twelve patients with primary open-angle glaucoma while on continuing therapy with timolol 0.5% twice daily and pilocarpine 4% four times a day in both eyes for 3 months were included in the study. A single drop of apraclonidine 1% or placebo was added to treatment with timolol and pilocarpine. Intraocular pressure (IOP) was measured on both days before a single drop of test medications in both eyes as well as 2,4,6, 8 and 12 h later. The fall in IOP with apraclonidine was significantly greater than with placebo at all time intervals (p < 0.05). This study suggests that apraclonidine provides an additive IOP-lowering effect to timolol and pilocarpine for at least 12 h after single-drop applications.

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Short-term Effects of Unilateral 1% Apraclonidine Therapy

Cited by 96 publications

References 14 publications

Localization of Alpha-2 Adrenergic Receptors in the Human Eye

Localization of Alpha-2 Adrenergic Receptors in the Human Eye

Mechanism of Aqueous Humor Secretion, Its Regulation and Relevance to Glaucoma

Short-Term Effect of Apraclonidine on Intraocular Pressure in Glaucoma Patients Receiving Timolol and Pilocarpine

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