Short-Term Efficacy of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Randomized Placebo-Controlled, Double-Blind Clinical Trial

Fukuda, Vanessa Ovanessian; Fukuda, Thiago Yukio; Guimarães, Márcio; Shiwa, Sílvia Regina; Lima, Bianca Del Cor de; Lopes-Martins, Rodrigo Álvaro Brandão; Casarotto, Raquel Aparecida; Alfredo, Patrícia Pereira; Bjordal, Jan Magnus; Fucs, Patricia M. M. B.

doi:10.1016/s2255-4971(15)30407-9

Cited by 26 publications

(29 citation statements)

References 37 publications

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“…These results are consistent with Fukuda et al [41] who investigated the effect of LLLT using GaAs laser. They revealed that treatment with LLLT alleviated pain and improved functional ability over the short term, among patients with knee osteoarthritis.…”

Section: Discussionsupporting

confidence: 92%

LASER versus electromagnetic field in treatment of hemarthrosis in children with hemophilia

Eid

Aly

2015

Lasers Med Sci

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Children with hemophilia usually have recurrent joint bleeding that leads to joint damage, loss of range of motion, and restriction of mobility, therefore affecting the quality of life in these children. The purpose of this study was to compare the effects of lowlevel laser therapy (LLLT) to that of pulsed electromagnetic field (PEMF) in treatment of hemarthrosis in children with hemophilia. Thirty boys with hemophilia A with ages ranging from 9 to 13 years were selected and assigned randomly, using sealed envelopes, into two equal intervention groups. The study group I received the traditional physical therapy program in addition to LLLT, whereas the study group II received the same physical therapy program given to the study group I in addition to PEMF. Both groups received the treatment sessions three times per week for three successive months. Pain, laboratory investigations, swelling, and range of motion (ROM) of the affected knee joint, in addition to physical fitness were evaluated before, at the end of the sixth week and at 12 weeks of the treatment program. Laser group showed significant improvement in all measured variables after the sixth week of treatment when compared with PEMF. By 12 weeks of treatment, there was a significant improvement in pain, ROM, ESR and leucocytes levels in laser group compared with PEMF, while there was no significant difference in knee circumferences and the 6-min walk test (6MWT) between both groups. Both groups showed significant improvement at 12 weeks of treatment compared with that at 6 weeks. Both LLLT and PEMF are effective modalities in reducing pain, swelling, increasing ROM and improving physical fitness. Twelve weeks of treatment of both modalities demonstrated significant improvement than 6 weeks of treatment. Laser therapy induced significant improvement than electromagnetic therapy in treatment of hemarthrosis-related problems in children with hemophilia.

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Section: Discussionsupporting

confidence: 92%

LASER versus electromagnetic field in treatment of hemarthrosis in children with hemophilia

Eid

Aly

2015

Lasers Med Sci

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“…However, in Fudka et al study, a laser with a wavelength of 904 nm was used in patients with knee osteoarthritis for three days a week PHYSICAL TREA MENTS and 9 sessions. In this study every point was emitted with 3 Jules power and finally the study result showed effectiveness of laser, compared with the placebo in reducing pain and improving function [22]. Our study was similar to Bulow et al study who emitted laser with wavelength of 830 nm and a total dose of 22.5 Jules on 9 points around the knee.…”

Section: Discussionsupporting

confidence: 84%

“…Evidence strongly suggests that laser can reduce acute pain with modulation of inflammatory markers such as PGE2, mRNA Cox 2, IL-1β, TNFα [21]. Moreover, laser can repair joint cartilage, proliferate cartilage cells, and synthesize and secret the extracellular matrix [22]. Ohshiro study showed that the laser had positive effects on blood flow and temperature, and thereby on reducing pain [23].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Low Level Laser Therapy on Pain and Range of Motion of Patients With Knee Osteoarthritis

Koutenaei

Mosallanezhad

Naghikhani

et al. 2017

PTJ

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Purpose: Osteoarthritis is one the most common chronic diseases of the joints that mostly affects knee joint. Low power laser is one the minimally invasive treatments of osteoarthritis. However, the efficacy of this therapy is still controversial. This study aimed to evaluate the efficacy of low power laser therapy in reducing pain and increasing knee range of motion compared to placebo laser. Methods:This study was a double-blind clinical trial performed at a day clinic in Tehran, Iran, from March 2016 to February 2017. Treatment for both groups comprised 10 sessions, 5 times a week. In this study, low power laser with a wavelength of 810 nm and a power of 100 mW at 8 points was applied around the knee during two weeks of treatment. At the same time, laser was applied in the placebo group, but the power output was zero. Data analyses were performed by repeated measures ANOVA test using SPSS version 20. Results:The mean pain score at rest (P=0.691), as well as at activity (P=0.751) were not significantly different between the two groups. The range of motion of knee flexion (P=0.435), and the range of motion of knee extension (P=0.885) showed no significant difference between two groups. Both interventions over time lead to a significant change in pain at rest and at activity and also increase in the range of motion in knee flexion and extension (P<0.05). Conclusion:Both placebo treatment with routine physiotherapy and active laser therapy with routine physiotherapy decreased knee pain and increased knee range of motion in patients affected with osteoarthritis and there was no significant difference between two therapies.

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“…Six studies 14,16,17,19,24,26 including 689 patients (354 LLLT and 335 placebo) assessed the pain in activity outcomes of the patients. The overall inverse variance pooled SMD calculated for pain in activity was -0.31 (95% CI; -0.55, -0.07) in favor of the LLLT (P = 0.01, Figure 4).…”

Section: -2-pain In Activitymentioning

confidence: 99%

“…29 Four studies 13,16,17,25 including 304 patients (137 LLLT and 167 placebo) assessed the range of motion outcomes of the patients. The overall inverse variance pooled SMD calculated for range of motion was 0.63 (95% CI; -0.13, 1.4).…”

Section: -Range Of Motionmentioning

confidence: 99%

Safety and Effectiveness of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis

et al. 2017

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Please cite this article as follows: Rayegani SM, Raeissadat SA, Heidari S, Moradi-Joo M. Safety and effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. J Lasers Med Sci. 2017;8(Suppl 1):S12-S19. doi:10.15171/ jlms.2017.s3. IntroductionOsteoarthritis is one of the most common diseases which has affected many people; this disease increases with age. In general, it may be said that approximately 14% of adults in United States and 40% of the population under 65 years old in Britain and Australia suffer from this disease; this disease prevalence is growing.1 Osteoarthritis is an example of physical and motor disability and one of the most important causes of functional disabilities in individuals, and imposes significant costs to individuals and consequently, to society. 2Knee osteoarthritis (KOA) is one of the most common osteoarthritis types and is associated with symptoms such as knee stiffness, pain, and limited movement range of knee joint. These conditions lead to physical function impairment, limited independence in doing daily life activities, decreased quality of life, and other disabilities. 3,4 KOA is also known as arthritis or knee joint stiffness; it mainly affects the articular cartilage. The articular cartilage is a soft tissue which is inside the joint and between bones; in the case of its damage, the bones will rub on each other and extended bone will be created around the joint. Ultimately, the ligaments and muscles around the joint will be narrowed and weakened. [1][2][3][4] There are several different treatments to control this disease (pharmacotherapy, surgery, physiotherapy, exercise therapy). It seems that the use of these methods depends on disease stage and patient's specific condition. In general, however, the logic and philosophy of these methods is relieving patient from pain, make him/her independent in doing daily life activities, and improving his/her life. 5Due to numerous complications which are associated with using non-steroidal drugs, using them to control this disease is limited. 5 Recently, other therapies which are based on rehabilitation methods (such as exercise therapy, tensile muscle movement, electrical stimulation, acupuncture, and heat therapy) are more considered by physicians than using non-steroidal drugs.6 Low-level laser therapy (LLLT) is one of the safe and non-invasive methods which has recently attracted the attention of Iran Health Insurance Organization, Tehran, Iran Abstract Introduction: Low-level laser therapy (LLLT) was introduced as an alternative non-invasive treatment for osteoarthritis, but its effectiveness is still controversial. The main objective of this article was to determine the safety and efficacy of LLLT in patients with knee osteoarthritis (KOA). Methods:In order to gather evidence, main medical databases as well as relevant websites were browsed without time limit. We searched with appropriate keywords and strategies. After quality assessment of studies, study data were extrac...

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Short-Term Efficacy of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Randomized Placebo-Controlled, Double-Blind Clinical Trial

Cited by 26 publications

References 37 publications

LASER versus electromagnetic field in treatment of hemarthrosis in children with hemophilia

LASER versus electromagnetic field in treatment of hemarthrosis in children with hemophilia

The Effect of Low Level Laser Therapy on Pain and Range of Motion of Patients With Knee Osteoarthritis

Safety and Effectiveness of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis

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