Short-term Efficacy of trichloroacetic acid in the treatment of cervical intraepithelial neoplasia

Speiser, Sophie

doi:10.26226/morressier.57162800d462b8029237f076

Cited by 3 publications

(8 citation statements)

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“…In this study, 97.2% subject successfully converted to negative VIA in 3 months follow up. However, this data was not statistically signifi cant (p=1.00) 4 TCA with a concentration of 85% had also been showing to be effective for the treatment of HPV infected patients without dysplasia. The cure rate was 81.6%.…”

Section: Discussionmentioning

confidence: 85%

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Efficacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive VIA Result

Suwartono

Andrijono

2020

Indones J Obstet Gynecol

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Objective: To investigate the effectiveness TCA 85% compared to cryotherapy to treat patients with positive IVA result.Method: This is a non-inferiority randomized controlled trial study. Patients with positive VIA result referred to Jatinegara Primary Health Center were included in this study. Eligible samples were then treated with either TCA 85% or cryotherapy. The treatment was determined using a random block sampling method. Samples were then followed up 3 months after treatment in order to determine VIA result conversion.Result: Thirty-six patients were treated with TCA 85% and 36 others were treated with cryotherapy. 35 (97,2%) patients treated with TCA 85% converted to negative VIA, whereas all of the patients that were treated with cryotherapy converted to negative VIA. Bivariate analysis fisher’s exact test was then conducted with a result P-value of 1.00 (p > 0,05).Conclusion: There was no statistically significant difference of result between TCA 85% and cryotherapy for treating patients with positive VIA result.Keywords: cervical cancer, cryotherapy, TCA 85%, VIA test. Abstrak Tujuan: Mengetahui efikasi TCA 85% pada tatalaksana IVA positif dibandingkan dengan krioterapiMetode: Penelitian ini merupakan penelitian randomized control trial menggunakan metode non-inferiority study. Subyek penelitian ini merupakan pasien dengan hasil IVA positif yang dirujuk ke Puskesmas Kecamatan Jatinegara, Jakarta Timur. Tatalaksana yang diberikan ditentukan menggunakan metode random block sampling. Subyek diikuti selama 3 bulan setelah tindakan untuk menentukan hasil konversi pemeriksaan IVA.Hasil: Sbenyak 36 subjek diterapi dengan TCA 85% dan 36 lainnya diterapi dengan krioterapi. Sebanyak 35 (97,2%) pasien yang ditatalaksana dengan TCA 85% mengalami konversi menjadi IVA negatif pada follow-up bulan ke-3, sedangkan seluruh pasien yang ditatalaksana dengan krioterapi menjadi konversi menjadi IVA negatif. Dilakukan analisis bivariat fisher’s exact test dan didapatkan nilai p sebesar 1,00 (p>0,05).Kesimpulan:Tidak ada perbedaan bermakna dari efikasi penggunaan TCA 85 % dibandingkan dengan krioterapi pada terapi IVA positif.Kata kunci: kanker serviks, krioterapi, pemeriksaan IVA, TCA 85%.

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Section: Discussionmentioning

confidence: 85%

“…It has previously been shown that topical TCA 85% has good effi cacy in treating grade I-III precancerous lesion. 4…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive VIA Result

Suwartono

Andrijono

2020

Indones J Obstet Gynecol

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“…The lack of systemic absorption of TCA after topical application, no risk of systemic side effects, safety during pregnancy, tolerability and affordable price has made it a good candidate for the treatment of CIN (MALVIYA et al, 1987;BOOTHBY et al, 1990;Demars et al, 1992;Zhu et al, 1992;Pezeshkpoor et al, 2012;Jayaprasad et al, 2016). Patients may experience minimal side effects such as pain, spotting, and increased vaginal discharge but these complications resolve shortly after application (Zhu et al, 1992;Geisler et al, 2016). Previous studies have proved TCA to be effective in the treatment of anogenital pre-cancerous lesions where it was found to have an added value in the treatment of immunocompromised patients with anal intraepithelial neoplasia (AIN) and vaginal intraepithelial neoplasia (VAIN) who cannot tolerate any invasive intervention (Lin et al, 2005;Singh et al, 2009).…”

Section: Research Articlementioning

confidence: 99%

Comparison between Single Versus Twice Application of Topical 85% Trichloroacetic Acid in the Treatment of Cervical Intraepithelial Neoplasia; A Randomized Clinical Trial on Efficacy and Tolerability

Ayatollahi

Ershadimoghaddam

Naji

et al. 2022

Asian Pac J Cancer Prev

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Purpose: To compare the efficacy and safety of up to two-time administration of 85% TCA, as a promising alternative therapy to conservative and surgical management of grade one to three CINs. Methods: In this two-armed randomized clinical trial, a total of 53 patients with biopsy-proven CIN lesions were allocated to two groups of TCA treatment. The first group (n=26) received a single dose of local therapy with 85% TCA while the second group (n=27) was treated on two separate occasions with a two-week interval. Two participants (one in each group) were lost to follow-up. At the two-month follow-up after TCA application, a colposcopy-guided biopsy was performed for all patients and the pathological specimens were studied by a single experienced pathologist to determine the post-intervention grading of CIN. Results: Two groups were comparable in terms of age and base-line lesion grading, as CIN 1 lesions comprised the majority of cases (54%), followed by CIN 2(37%). While our sample was a poor representative of CIN3 lesions (7%), no significant difference was noticed between the single and twice TCA treated groups with a response rate of 52% and 54% respectively (either complete remission to normal histology or regression to any low-grade lesion). Either separate analysis (with respect to the base-line grading within each treatment group) or combined analysis (regardless of CIN sub-group) could not generate any statistical significance. The second dose of TCA did not increase the frequency of reported adverse events. Conclusion: The second dose of topical 85% TCA does not seem to increase the CIN response rate more so than its single dose. However, further controlled clinical trials with larger samples are warranted to verify current findings. The use of TCA was not limited by any major side effect, therefore, the potential to achieve an increased efficacy with more frequent TCA applications is appealing.

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“…We suggest that the local application of TCA in the nasal cavity in a concentration of either 50% or 80% for about 1 min may preclude or markedly reduce the entry of SARS‐CoV‐2 and destroy the virus itself. TCA has been proved to be effective and safe and has been used for years in the treatment of viral‐driven lesions, especially in a sensitive mucosa 58‐64 …”

mentioning

confidence: 99%

“…TCA has been proved to be effective and safe and has been used for years in the treatment of viral-driven lesions, especially in a sensitive mucosa. [58][59][60][61][62][63][64] TCA is inexpensive, with easy administration as a single time procedure that takes only a couple of minutes and can be provided by a skilled person (physician or trained nurse) in almost every setting, especially in countries with limited medical and financial recourses.…”

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confidence: 99%

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Abdelhadi

Ruszczak

Schwartz

2020

Dermatologic Therapy

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Since the spread of SARS‐CoV‐2 became a pandemic, the number of cases has been continuously growing worldwide. Numerous recommendations and suggestions have been published to prevent the acquisition and spread of the SARS‐CoV‐2, especially to protect health workers and front‐line caregivers. SARS‐CoV‐2 is transmitted by aerosol, rendering air defense with suitable ventilation and adequate mask use pivotal. Recently, locally applied antiseptic, antiviral, or structure competitive receptor blockers were suggested to attack the virus at its main point of invasion, the nasal mucosa and nasopharynx. We discuss the most plausible and safe ideas to reduce viral load at the point of entry, and subsequently the spread of SARS‐CoV‐2 to the lower respiratory tract, lungs, and other organs. In addition, we analyze the value and recommend clinical trials employing topical trichloroacetic acid (TCA), a substance well known from dermatologic and cosmetic procedures. It has been proven to successfully block the nasal entry for airborne allergens, preventing the development of allergic rhinitis and asthma, and to be curative for early stages of viral infections entering through the oral mucosa. For SARS‐CoV‐2, TCA in a single, short‐time application is expected to remodel the nasal and nasopharyngeal epithelia, eliminating both the receptors and cells responsible for viral entry and subsequent viral spread to the lower respiratory tract. Moreover, this may have therapeutic benefits for those recently infected by reducing local viral replication. Such procedures are cheap, safe, and can be conducted in almost every setting, especially in regions with inadequate financial and logistic resources.

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Short-term Efficacy of trichloroacetic acid in the treatment of cervical intraepithelial neoplasia

Cited by 3 publications

References 0 publications

Efficacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive VIA Result

Efficacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive VIA Result

Comparison between Single Versus Twice Application of Topical 85% Trichloroacetic Acid in the Treatment of Cervical Intraepithelial Neoplasia; A Randomized Clinical Trial on Efficacy and Tolerability

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

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