Short-Term Exercise Training Alters Leukocyte Chemokine Receptors in Obese Adults

Barry, Julianne; Simtchouk, Svetlana; Durrer, Cody; Jung, Mary E.; Little, Jonathan P.

doi:10.1249/mss.0000000000001261

Cited by 55 publications

(60 citation statements)

References 38 publications

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“…Interestingly, we observed a significant decrease in the proportion of CCR2‐expressing HSPCs specifically in individuals with obesity and a decrease in overall CCR2 expression, which was independent of weight status. Our research extends recent research that has shown that exercise can reduce the level of expression of CCR2 on inflammatory monocytes in individuals with obesity (Barry et al . 2017) to show that CCR2 is also reduced in HSPCs, inflammatory monocyte precursors.…”

Section: Discussionsupporting

confidence: 88%

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Niemiro

Allen

Mailing

et al. 2018

The Journal of Physiology

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Circulating progenitor cells (CPCs) and subpopulations are normally found in the bone marrow, but can migrate to peripheral tissues to participate in local inflammation and/or remodelling. The purpose of this study was to compare the CPC response, particularly the inflammatory-primed haematopoietic stem and progenitor (HSPC) subpopulation, to a 6 week endurance exercise training (EET) intervention between lean and obese adults. Seventeen healthy weight (age: 23.9 ± 5.4 years, body mass index (BMI): 22.0 ± 2.6 kg m ) and 10 obese (age: 29.0 ± 8.0 years, BMI: 33.1 ± 6.0 kg m ) previously sedentary adults participated in an EET. Blood was collected before and after EET for quantification of CPCs and subpopulations via flow cytometry, colony forming unit assays and plasma concentrations of C-X-C motif chemokine 12 (CXCL12), granulocyte-colony stimulating factor (G-CSF), and chemokine (C-C motif) ligand 2 (CCL2). Exercise training reduced the number of circulating HSPCs and adipose tissue-derived mesenchymal stem cells (AT-MSCs). EET increased the colony forming potential of granulocytes and macrophages irrespective of BMI. EET reduced the number of HSPCs expressing the chemokine receptor CCR2 and the pro-inflammatory marker TLR4. EET-induced changes in adipose tissue-derived MSCs and bone marrow-derived MSCs were negatively related to changes in absolute fitness. Our results indicate that EET, regardless of BMI status, decreases CPCs and subpopulations, particularly those primed for contribution to tissue inflammation.

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Section: Discussionsupporting

confidence: 88%

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Niemiro

Allen

Mailing

et al. 2018

The Journal of Physiology

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“…This newly proposed short-term intervention indicated an overall unchanged effect on body composition parameters, which was in line with other exercise interventions [19,17,[28][29][30]. However, Robinson et al [15] reported a significant reduction in body weight and BMI following 2 short-term exercise programs (highintensity aerobic training, 4 × 1 min cycling exercise, and moderate-intensity exercise, 50 min of continuous cycling exercises) in the OW/OB prediabetic patients.…”

Section: Discussionsupporting

confidence: 69%

“…In this study, a slight but significant increase was observed in FFM (2.06%) and SMM (1.9%). The combined interventions were effective in increasing muscle mass, while there existed no report on high-intensity aerobic training [28,29]. The incidence of cardiovascular disease (CVD) and its associated total mortality rate could be predicted by evaluating body composition [31], while both the increase in FM and FFM reduction could generate identical %FM values in different conditions from obesity to hidden cachexia; consequently, the effective changes in body composition could not be reflected by %FM alone.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on TLR4, NF-κB and IRF3 Expression in Young Overweight and Obese Girls

Soltani¹,

Esmaeil²,

Marandi³

et al. 2020

Public Health Genomics

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Obesity is commonly associated with immunometabolic dysfunctions. Activation of inflammatory macrophages through TLR4 (toll-like receptor 4) and the anti-inflammatory impact of exercise have been and are the new concerns among researchers. A new short-term combined high-intensity interval training was proposed in young sedentary overweight/obese females. All participants were allocated to one of two groups: the exercise group (EG) and the control group (CG), where the EG participated in a 2-week combined training and the CG continued its routine lifestyle. Gene expression levels of TLR4, NF-κB (nuclear factor κB), and IRF3 (interferon regulatory factor 3) were assessed by real-time PCR. Physiological, anthropometric, and biomedical metabolic factors were assessed. The between-group comparisons indicated a tendency to a decrease in NF-κB gene expression in the EG. The IRF3 levels were not significantly changed compared to CG and the levels before training. Fasting glucose levels and β-cell function revealed a significant improvement in EG. These findings indicated that this protocol decreased meta-inflammation levels and improved insulin resistance independent of body composition changes. Consequently, combined training may be recommended as a therapeutic approach in metabolic diseases.

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“…Evaluated the effect of HIIT in obese women with type 2 diabetes and found an improvement in inflammatory profile through the decreased expression of TLR‐4 and TLR‐2 in the cell surface of lymphocytes and monocytes after 2 weeks of training. Furthermore, HIIT induces immune stimulatory actions such as the increasing potential for CCR5‐mediated chemotaxis and improvements in oxidative burst and phagocytosis of stimulated‐leukocytes …”

Section: Discussionmentioning

confidence: 99%

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

et al. 2018

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This study investigated the acute and chronic effects of 4 weeks of High Intensity Interval Training (HIIT) on cytokines and oxidative stress markers in postmenopausal obese women. Ten post‐menopause sedentary obese women (age 58.25 ± 3.10 years; BMI 31.70 ± 1.34 kg/m²) performed 4 weeks of high intensity interval exercise (60 seconds of effort at 85%‐90% Maximal Heart Rate interspersed by 75 seconds of recovery at sessions of 40% Maximal Heart Rate) twice a week. Blood samples were collected before and immediately after the first and the last (8th) high intensity interval exercise (HIIE) session to analyze interleukin(IL)‐1β, IL‐1ra, IL‐6, IL‐10, monocyte chemoattractant protein‐1 (MCP‐1) levels and lipid peroxidation (TBARS), nitrites, and advanced oxidation protein products (AOPP). An elevation in MCP‐1, IL‐6, and IL‐10 levels and in TBARS and AOPP occurred immediately after the first HIIE. After 4 weeks of HIIT, the participants presented lower levels of IL‐6 and higher amounts of IL‐1ra and IL‐10 at rest. The last HIIE session induced an elevation only in IL‐6, IL‐10, and IL‐1ra levels, but not in MCP‐1, IL‐1β, and TBARS levels. In conclusion, HIIT induced anti‐inflammatory effects in postmenopausal obese women, with little changes in oxidative stress markers.

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Short-Term Exercise Training Alters Leukocyte Chemokine Receptors in Obese Adults

Cited by 55 publications

References 38 publications

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on TLR4, NF-κB and IRF3 Expression in Young Overweight and Obese Girls

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

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