2001
DOI: 10.1097/00002030-200110190-00021
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Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy

Abstract: Exercise/physical activity is increasingly being advocated as a positive addition to the treatment regimen of HIV-positive individuals. We investigated the effects of 10 weeks' aerobic and resistance training on individuals with HIV-related lipodystrophy. These individuals demonstrated an improvement in exercise tolerance, body composition and blood lipid profiles. Potentially, such changes may contribute to an amelioration of some of the adverse metabolic effects associated with highly active antiretroviral t… Show more

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Cited by 102 publications
(83 citation statements)
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“…Previous studies on the effects of CET on metabolic and anthropomorphic abnormalities in HAART-treated HIV + patients were limited by small sample sizes, were disproportionate with respect to gender, and were not largely controlled. [21][22][23][24][25] We believe our findings are particularly important due to increasing access to HAART in sub-Saharan countries and the potential for increased CVD and diabetes risks for HIV + patients starting HAART.…”
Section: Discussionmentioning
confidence: 82%
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“…Previous studies on the effects of CET on metabolic and anthropomorphic abnormalities in HAART-treated HIV + patients were limited by small sample sizes, were disproportionate with respect to gender, and were not largely controlled. [21][22][23][24][25] We believe our findings are particularly important due to increasing access to HAART in sub-Saharan countries and the potential for increased CVD and diabetes risks for HIV + patients starting HAART.…”
Section: Discussionmentioning
confidence: 82%
“…Based on previous studies, [22][23][24] we estimated that a sample of 37 individuals in each group would have a power of 90% to detect a 10% difference in triglycerides and total cholesterols for α = 0.05. Assuming a drop-out of 20% per group, at least 44 participants would be required per group.…”
Section: Statistical Analysesmentioning
confidence: 99%
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“…Estudo realizado por Jones et al 23 , ao investigarem seis pacientes com HIV/AIDS, também verificaram aumento na circunferência do braço e da perna. Entretanto, vale ressaltar que os mesmos realizaram 10 semanas de treinamento concorrente.…”
Section: Discussionunclassified
“…Particularmente entre PVH, estudo epidemiológico observacional com 220 pessoas atendidas em um Centro de Referência do município de São Paulo, demonstrou que os escores de prática de atividades físicas no tempo de lazer foram inversamente associados com indicadores de gordura centrípeta, tais como a razão cinturaquadril e com a somatória das espessuras de dobras cutâneas da região central do corpo (Florindo et al, 2007). Analogamente, estudos experimentais, realizados com PVH em TARV, também têm mostrado que exercícios físicos podem melhorar a força muscular e a capacidade cardiorrespiratória e contribuem de forma significativa para diminuir a gordura centrípeta (tanto visceral como subcutânea), melhorar a aptidão física relacionada à saúde e melhorar a qualidade de vida (Roubenoff et al, 1999a, b;Agin et al, 2001;Jones et al, 2001;Yarasheshi et al, 2001;Terry et al 2006;Engelson et al, 2006;Fillipas et al, 2006;Lindegaard et al, 2008;Robinson et al, 2007); e para a normalização das concentrações plasmáticas de lípides (Jones et al, 2001;Thoni et al, 2002) e de glicose (Driscoll et al, 2004). Estudos de revisão sistemática e meta-análise mostraram que a intervenção com exercícios físicos em PVH foi segura e benéfica para os componentes de aptidão cardiorrespiratória e força (O'Brien et al, 2008(O'Brien et al, , 2010(O'Brien et al, , 2016a(O'Brien et al, , b, 2017 (Dolan et al, 2006;Cobbing et al, 2014;Jaggers et al, 2016).…”
Section: Introductionunclassified