Short-term feeding of a diet enriched in phospholipids increases bile formation and the bile acid transport maximum in rats

Rioux, F M; Perea, A.; Im, Y-H.; Lévy, Émile; Malli, Lina; Mc, Carrillo; Tuchweber, Béatriz

doi:10.1016/0005-2760(94)90044-2

Cited by 21 publications

(15 citation statements)

References 43 publications

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“…According to Rioux et al (35) and LeBlanc et al (36) , the supplementation of phosphatidylcholine in the diet of rats increased bile juice flow, phosphatidylcholine content in the bile juice, and bile cholesterol content. These factors indicate that phosphatidylcholine has an indirect emulsifying role in fat digestion.…”

Section: Resultsmentioning

confidence: 97%

Performance of Broilers Fed Different Dietary Choline Sources and Levels

et al. 2017

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Two experiments were carried out to evaluate the bioequivalence of a commercial phosphatidylcholine source (Biocholine™) as an alternative to choline chloride and the choline requirements of broilers of a fast-growth strain. In Experiment I, 672 broilers were fed four Biocholine™ levels (0, 100, 200, or 300 mg/kg) and three choline levels (200, 400, or 600 mg/kg) supplied as choline chloride between 4 and 28 days (d) of age. In Experiment II, 462 broilers received diets supplemented with 0, 200, 400, 600 or 800 mg/kg choline as choline chloride. In both experiments, diets were based on white rice, soybean meal, and corn gluten. In Experiment I, birds fed choline chloride presented higher feed intake than those fed Biocholine™. Both choline supplements linearly improved feed conversion ratio (FCR) between 15 and 28 d, but the curves presented different slopes, showing that one unit (U) of Biocholine™ was equivalent to 2.52 U of choline supplied as choline chloride. In Experiment II, the supplementation of choline had a quadratic effect on weight gain (WG) but did not affect FCR. Choline requirements for WG were determined as 778, 632, and 645 mg/kg for 1-7, 1-35, and 1-42 d of age, respectively.

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Section: Resultsmentioning

confidence: 97%

Performance of Broilers Fed Different Dietary Choline Sources and Levels

et al. 2017

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“…The amount of PC secreted into bile is influenced by several factors (20): 1) the intracanalicular bile salt concentration (21,22); 2) the hydrophobicity of the intracanalicular bile salts (23); 3) the magnitude of the bile salt-independent fraction of the bile flow (24); 4) the concentration of hydrophilic organic anions (25); 5) the abundance of Mdr2 at the bile canalicular membrane (3,16,26); and 6) the lipid composition of the bile canalicular membrane (27)(28)(29)(30). Taurocholate feeding did not induce detectable changes in Mdr2 mRNA or protein levels (Fig.…”

Section: Discussionmentioning

confidence: 99%

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

Verkade

Havinga

Shields

et al. 2007

Journal of Lipid Research

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The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC. We evaluated whether the PEMT pathway is quantitatively important for biliary PC secretion in mice under various experimental conditions. Biliary bile salt and PC secretion were determined in mice in which the gene encoding PEMT was inactivated (Pemt 2/2 ) and in wild-type mice under basal conditions, during acute metabolic stress (intravenous infusion of the bile salt tauroursodeoxycholate), and during chronic metabolic stress (feeding a taurocholatecontaining diet for 1 week). The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Under basal conditions, Pemt 2/2 and wild-type mice exhibited similar biliary secretion rates of bile salt and PC (?145 and ?28 nmol/min/100 g body weight, respectively). During acute or chronic bile salt administration, the biliary PC secretion rates increased similarly in Pemt 2/2 and control mice. Mdr2 mRNA and protein abundance did not differ between Pemt 2/2 and wild-type mice. The cytidylyltransferase activity in hepatic lysates was increased by 20% in Pemt 2/2 mice fed the basal (bile salt-free) diet (P , 0.05). We conclude that the biosynthesis of PC via the PEMT pathway is not quantitatively essential for biliary PC secretion under acute or chronic bile salt administration.-Verkade, H.

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“…The LG ϩ 2% PC diet did not show a significant effect on bile flow, bile acids, or in biliary lipid secretion as compared with the LG diet alone. The increase in bile flow in mice fed the LG ϩ 6% PC diet could be explained by the increase in biliary bile acid secretion (36). However, the increase in biliary PL secretion might be due to the fact that dietary PC can stimulate HDL-PC uptake by the liver, and thus PC can be released either from the preformed pool or from the newly synthesized pool (37).…”

Section: Downloaded Frommentioning

confidence: 99%

Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis

Kasbo

Tuchweber

Perwaiz

et al. 2003

Journal of Lipid Research

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Cholesterol gallstones affect approximately 10-15% of the adult population in North America. Phosphatidylcholine (PC) is considered to be the main cholesterol solubilizer in bile. This study examined the effect of a PCenriched diet on gallstone incidence in mice susceptible to cholelithiasis. The result obtained showed that the feeding of a lithogenic (LG) diet for 4 weeks or 8 weeks resulted in cholesterol gallstone incidences of 47% and 89%, respectively. These gallstone incidences were either reduced or prevented when the LG diet was enriched with 2% or 6% PC, respectively. The cholesterol saturation index (CSI) was reduced only in mice fed with LG ؉ 6% PC diet as compared with mice fed the LG diet alone. However, in all groups, the CSI was significantly higher than in mice fed Purina chow diet. The biliary anionic polypeptide fraction (APF) was significantly increased in mice fed the LG ؉ 2% PC diet and was reduced in those fed with LG ؉ 6% PC diet. In conclusion, prevention or delay of gallstone formation was not due to a consistent effect on biliary lipid composition, suggesting a direct effect of PC on cholesterol solubilization and/or the effect of an additional nonlipid biliary component such as APF.

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Short-term feeding of a diet enriched in phospholipids increases bile formation and the bile acid transport maximum in rats

Cited by 21 publications

References 43 publications

Performance of Broilers Fed Different Dietary Choline Sources and Levels

Performance of Broilers Fed Different Dietary Choline Sources and Levels

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis

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