“…Autophagy mediated by AMPK/mTORC1 pathway is also induced by statin treatment (Zhang et al, ), which was also shown to reduce the levels of tau phosphorylation as well as Aβ burden and neurotoxicity in several in vitro and in vivo models; and to prevent oxidative stress and cognitive impairments in AD mice model (Li, Lin, & Huang, ). Omega‐3 fatty acids, which were shown to induce autophagy by inhibiting the Akt/mTORC1 signaling and by disrupting beclin 1‐Bcl‐2 binding (Levine, Packer, & Codogno, ), also found to be beneficial in various preclinical models of AD, although the results are not entirely consistent between studies (Calon, ; Lim et al, ; Milanovic et al, ). Another less studied inducer of autophagy is spermidine, whose levels decline with aging, and a possible connection between reduced endogenous spermidine levels and age‐related degeneration has been suggested (Madeo, Bauer, Carmona‐Gutierrez, & Kroemer, ).…”